Evaluation of myocardial mechanics with three-dimensional speckle tracking echocardiography in heart transplant recipients: comparison with two-dimensional speckle tracking and relationship with clinical variables

Urbano-Moral, José Ángel; Arias-Godínez, José Antonio; Ahmad, Raabia; Malik, Rabiya; Kiernan, Michael S.; DeNofrio, David; Pandian, Natesa G.; Patel, Ayan R.

doi:10.1093/ehjci/jet065

Cited by 41 publications

(48 citation statements)

References 24 publications

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“…20 Acquisition of 3D data sets and off-line analysis for speckle tracking were performed as previously described. 21,22 In summary, 3D data sets consisted of LV full pyramidal volumes, were acquired with the Matrix Array PST-25SX transducer from the apical position, and were created by the combination of 6 ECG-gated subvolumes. The off-line speckle tracking analysis was performed using the Wall Motion Tracking software (Toshiba) and blinded to late gadolinium enhancement (LGE) results.…”

Section: Echocardiographymentioning

confidence: 99%

Investigation of Global and Regional Myocardial Mechanics With 3-Dimensional Speckle Tracking Echocardiography and Relations to Hypertrophy and Fibrosis in Hypertrophic Cardiomyopathy

Urbano-Moral

Rowin

Maron

et al. 2014

Circ: Cardiovascular Imaging

156

105

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Background-In hypertrophic cardiomyopathy (HCM), heterogeneous myocardial hypertrophy and fibrosis are responsible for abnormalities of left ventricular (LV) function. We aimed to characterize LV global and regional myocardial mechanics in HCM, according to segmental hypertrophy and fibrosis. Methods and Results-Fifty-nine patients with HCM underwent standard echocardiography, 3-dimensional speckle tracking echocardiography, and cardiac magnetic resonance with late gadolinium enhancement (LGE); all 3 tests were <24 hours apart. Longitudinal, circumferential, and area strains were investigated according to the extent of LGE (no LGE, LGE<10%, and LGE≥10%), segmental thickness (≥15 versus <15 mm), and segmental LGE (LGE versus non-LGE 001).Parameters of global myocardial mechanics showed no association with the extent of LGE; in contrast, the extent of LGE was associated with the extent of hypertrophy. All 3 deformation parameters were attenuated both in segments ≥15 mm in thickness and in those with LGE; adjusted analysis demonstrated that segmental presence of LGE was associated with additional attenuation in myocardial deformation. Conclusions-Both hypertrophy and fibrosis contribute to regional impairment of myocardial shortening in HCM. The extent of hypertrophy is the primary factor altering global myocardial mechanics. Circumferential myocardial shortening seems to be directly involved in preservation of LV systolic performance in HCM. (Circ Cardiovasc Imaging. 2014;7:11-19.)

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Section: Echocardiographymentioning

confidence: 99%

Investigation of Global and Regional Myocardial Mechanics With 3-Dimensional Speckle Tracking Echocardiography and Relations to Hypertrophy and Fibrosis in Hypertrophic Cardiomyopathy

Urbano-Moral

Rowin

Maron

et al. 2014

Circ: Cardiovascular Imaging

156

105

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“…UrbanoMoral et al reported that 3D-STE-derived, but not 2D-derived, global LS was independently associated with NYHA functional class in heart transplant recipients, which suggests a clinically relevant relation between functional status and 3D myocardial mechanics in heart transplant recipients. 53 In primary or secondary cardiomyopathies, late gadolinium-enhanced MRI has been widely used to identify myocardial characteristics, but 3D-STE also has the potential to provide additional information on myocardial characteristics. Matsumoto et al reported novel insights of the LV mechanics of dilated cardiomyopathy.…”

Section: Novel Insights From Clinical Studiesmentioning

confidence: 99%

Three-Dimensional Speckle Tracking Echocardiography

Seo

Ishizu

Atsumi

et al. 2014

Circ J

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Speckle tracking echocardiography (STE) was popularized in the first decade of this century. Analysis of cardiac mechanics has been the focus of ultrasonics, and the breakthrough came with STE. Beyond analysis solely of left ventricular ejection fraction, STE allows the assessment of various pathophysiologies, including myocardial layer-specific myocardial function, twist and rotation, and dyssynchrony. Recent developments in the technology have resulted in commercially available 3-dimensional (D)-STE systems. Through experimental studies and clinical investigations, the reliability and feasibility of 3D-STE-derived data have been validated, and the advantages of 3D-STE over 2D-STE have been revealed. In addition, because of the 3D nature of the technology, 3D-STE provides novel deformation parameters (ie, 3D-strain and area change ratio) that have the potential for more accurate assessment of overall and regional myocardial function. Recently, various preliminary studies using 3D-STE have reported on myocardial characteristics, novel mechanics in the left ventricle, prediction of therapeutic effects, observations of cardiac function through interventions, and challenges for left atrial and right ventricular functions. In this review, we focus on the features of the methodology, validation, and clinical application of 3D-ST.

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“…They demonstrated that the systolic function of the endocardial fiber is mostly influenced by the LS, and the motion of the midwall fiber was significantly related to the RS [38]. Additionally, the midwall fiber is primarily responsible for the LV circular motion; therefore, the greatest influence on the CS and RS is the midwall fiber [39]. AS, composite motion of LS and CS, is a new concept that regional wall motion is quantified through the magnitude of deformation in an endocardial surface area [40].…”

Section: Myocardial Deformation Changes In Patients With Osamentioning

confidence: 99%

Left ventricular subclinical dysfunction associated with myocardial deformation changes in obstructive sleep apnea patients estimated by real-time 3D speckle-tracking echocardiography

Wang

et al. 2015

Sleep Breath

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Evaluation of myocardial mechanics with three-dimensional speckle tracking echocardiography in heart transplant recipients: comparison with two-dimensional speckle tracking and relationship with clinical variables

Cited by 41 publications

References 24 publications

Investigation of Global and Regional Myocardial Mechanics With 3-Dimensional Speckle Tracking Echocardiography and Relations to Hypertrophy and Fibrosis in Hypertrophic Cardiomyopathy

Investigation of Global and Regional Myocardial Mechanics With 3-Dimensional Speckle Tracking Echocardiography and Relations to Hypertrophy and Fibrosis in Hypertrophic Cardiomyopathy

Three-Dimensional Speckle Tracking Echocardiography

Left ventricular subclinical dysfunction associated with myocardial deformation changes in obstructive sleep apnea patients estimated by real-time 3D speckle-tracking echocardiography

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