Evaluation of mutagenic activities of leachates in landfill sites by micronucleus test and comet assay using goldfish

Deguchi, Yuya; Toyoizumi, Tomoyasu; Masuda, S.; Yasuhara, Akio; Mohri, Shino; Yamada, Masato; Inoue, Yuzo; Kinae, Naohide

doi:10.1016/j.mrgentox.2006.11.006

Cited by 68 publications

(29 citation statements)

References 28 publications

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“…The fresh leachate had low acid in the range of 5.09-5.61, high concentrations of ionic constituents as electro-conductivity 19.80 ± 1.87 mS/cm and chloride 2,662 ± 897 mg/l. It had low levels of heavy metals (0.0-1.4 mg/l) similarly to the landfill raw leachate [15]. For TP and NH 3 -N, there were high concentrations of 17.86 ± 10.78 mg/l and 375 ± 61 mg/l, respectively, as compared to the general landfill leachate [15].…”

Section: Resultsmentioning

confidence: 90%

“…It had low levels of heavy metals (0.0-1.4 mg/l) similarly to the landfill raw leachate [15]. For TP and NH 3 -N, there were high concentrations of 17.86 ± 10.78 mg/l and 375 ± 61 mg/l, respectively, as compared to the general landfill leachate [15]. Additionally, large amount of total solids of 22,953 ± 4,022 mg/l over 90 % in soluble forms were found.…”

Section: Resultsmentioning

confidence: 96%

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Chemical characterization in correlation to toxicity evaluation for water reuse of solid waste leachates in the itMBR-RO system

Polngam

Chiemchaisri

Kaewmanee

et al. 2014

J Mater Cycles Waste Manag

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This research investigates chemical characterization and toxicity evaluation of solid waste leachates along operating treatment units of the itMBR-RO (inclined tubes membrane bioreactor-reverse osmosis) system. Leachates from solid waste disposal sites contain high pollutant concentrations that pose acute toxicity effects on living organisms. Overall treatment processes could reduce COD, ammonia nitrogen and heavy metals by [99, [99 and [97 %, respectively. The xenobiotic compounds can be effectively removed (83.2-100 %) with the itMBR-RO system. 96 h of toxicity tests revealed that not only was NH 3 toxic to the Nile Tilapia (Oreochromis niloticus), there were other pollutants in the leachate synergy such as COD, nitrite and conductivity. Nitrite was the most potent pollutant in the MBR-treated leachates giving an acute toxic effect in combination with ammonia. In conclusion, the itMBR-RO system could completely eliminate acute toxicity of the solid waste leachates; although a few toxic organic compounds still remained in the RO permeate i.e. DEHP, hexadecanoic acid and phenol, 2, 4-bis-(tert-butyl).

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Section: Resultsmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 96%

Chemical characterization in correlation to toxicity evaluation for water reuse of solid waste leachates in the itMBR-RO system

Polngam

Chiemchaisri

Kaewmanee

et al. 2014

J Mater Cycles Waste Manag

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“…Various organic contaminants as polycyclic aromatic hydrocarbons (PAH's), polychlorinated biphenyls (PCB's), phenols, phthalate esters and pesticides can pose synergistic and antagonistic toxicity, carcinogenicity or estrogenicity (Matejczyk et al 2011). The genotoxicity of landfill leachate was studied by Deguchi et al (2007) by performing comet and micro-nuclei tests in erythrocytes from peripheral blood and gill cells from goldfish (Carassius auratus). The effects of genotoxicity of organic contaminants and free radicals to heart, kidney, liver other organs of mice are described by Li et al (2006 a, b).…”

Section: Probing the Dump Interior Through Geochemistrymentioning

confidence: 99%

Paradigms on landfill mining: From dump site scavenging to ecosystem services revitalization

Burlakovs

Kriipsalu

Kļaviņš

et al. 2017

Resources, Conservation and Recycling

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For the next century to come, one of the biggest challenges is to provide the mankind with relevant and sufficient resources. The recovery of secondary resources plays a significant role. The industrial processes developed for regaining minerals for production of commodities in a circular economy become ever more important in the European Union and worldwide. Landfill mining (LFM) constitutes an important technological toolset of processes that regain the resources and redistribute them with an accompanying diminishment of hazardous influence of environmental contamination and other threats for human health hidden in former dump sites and landfills. 'Classical LFM' is a useful technology to discover hidden resources and look at the big picture of resources in the local, regional and global perspective. Therefore, this paper considers development of paradigms and attitudes to LFM as the technology for regaining calorific value; the furthering of deposited material valuable to more advanced concepts of enhanced LFM (ELFM); the recovery of landfill space and land value, and, finally, the possibility of full ecosystem services revitalization. The future of our civilisation depends on our wise use of commodities. Thus, waste operations beyond the Zero waste concept must be applied if mankind is to conquer space and the abyssal plains to conduct mining in the deepest oceans on the Earth. Other research areas feasible for LFM in terms of the environmental rehabilitation are given in the review. This compilation summarises the previous, current and future trends of LFM 2 technology regarding the paradigm developments that are influencing the attitude of scientists, industry and society to LFM as a complex tool for implementing the circular economy in practice. This review paper is based on a historical overview of global case studies and explores the methodology of waste management as regards the different tools for geochemical, geophysical and remote sensing that are used for field studies prior to the decisions whether LFM will be successful in an individual case. New technological developments of ELFM for the energy industry is described combined with a review of innovative material production. One chapter is dedicated to the Efficient Use of Resources and Optimal Production Economy (EUROPE) estimation model. The hazardous impacts of landfills, such as greenhouse gas emission and pollutants, are discussed. Throughout history, the major part of the 'LFM economy' has been viewed from a point of view of recovery of natural resources. Therefore, our main philosophy was to provide a historical experience linking with modern ideas of LFM to the increasingly relevant concept of a circular economy. The world is heading towards a restricted access to key resources. However, humanity should not limit itself to frame these restrictions but should also have a profound view on the global economy and life styles for future generations from an environmental and non-material resource standpoint. It is concluded that the big ...

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“…In India, 7.2 million tonnes of hazardous waste are generated per year, out of which 5.2 million tonnes are destined for disposal on land [TERI, 2003]. Leachates generated from solid waste landfill sites are thought to be one of the main sources of water pollution [Deguchi et al, 2007]. Serious adverse health effects, such as birth defects and certain types of cancer, have been reported in communities exposed to ground water contaminated by nearby industrial activities [Sekaran et al, 2000;Vrijheid, 2000;White and Claxton, 2004].…”

Section: Introductionmentioning

confidence: 99%

“…The assay has been adapted for genotoxicity assessment in a wide variety of organisms, including yeast [Miloshev et al, 2002], earthworms [Rajaguru et al, 2003], Drosophila [Siddique et al, 2003;2005a], and goldfish [Deguchi et al, 2007]. Dixion et al [2002] indicated that the Comet assay has the potential for investigating the indirect effects of the chemical constituents of complex chemical mixtures on DNA repair.…”

Section: Introductionmentioning

confidence: 99%

DNA damage induced by industrial solid waste leachates in Drosophila melanogaster: A mechanistic approach

Siddique

Sharma

Gupta

et al. 2008

Environ and Mol Mutagen

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Genomic stability requires that error-free genetic information be transmitted from generation to generation, a process that is dependent upon efficient DNA repair. Industrial leachates which contain mixtures of diverse chemicals are a major environmental concern. The interaction between these chemicals may have synergistic, antagonistic, or simply additive effects on biological systems. In the present study, the Comet assay was used to measure the DNA damage produced by leachates of solid wastes from flashlight battery, pigment, and tanning factories in the midgut cells and brain ganglia of Drosophila melanogaster mutants deficient in DNA repair proteins. Larvae were allowed to feed for 48 or 72 hr on diets containing 0.1, 0.5, and 2.0% (v/v) of the leachates. Physicochemical analysis run on the solid wastes, leachates, and treated larvae detected elevated levels of heavy metals. Leachates produced significantly greater levels of DNA damage in mutant strains mei41 (deficient in cell cycle check point protein), mus201 (deficient in excision repair protein), mus308 (deficient in postreplication repair protein), and rad54 (deficient in double strand break repair protein) than in the OregonR(+) wild-type strain. Larvae of the ligaseIV mutant (deficient in double strand break repair protein) were hypersensitive only to the pigment plant waste leachate. Conversely, the dnase2 mutant (deficient in protein responsible for degrading fragmented DNA) was more sensitive to DNA damage induction from the flashlight battery and tannery waste leachates. Our data demonstrate that repair of DNA damage in organisms exposed to leachates is dependent upon several DNA repair proteins, indicative of the involvement of multiple overlapping repair pathways. The study further suggests the usefulness of the Comet assay for studying the mechanisms of DNA repair in Drosophila.

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Evaluation of mutagenic activities of leachates in landfill sites by micronucleus test and comet assay using goldfish

Cited by 68 publications

References 28 publications

Chemical characterization in correlation to toxicity evaluation for water reuse of solid waste leachates in the itMBR-RO system

Chemical characterization in correlation to toxicity evaluation for water reuse of solid waste leachates in the itMBR-RO system

Paradigms on landfill mining: From dump site scavenging to ecosystem services revitalization

DNA damage induced by industrial solid waste leachates in Drosophila melanogaster: A mechanistic approach

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