Evaluation of multiwalled carbon nanotubes toxicity in two fish species

Cimbaluk, Giovani Valentin; Ramsdorf, Wanessa Algarte; Perussolo, Maiara Carolina; Santos, Hayanna Karla Felipe; Assis, Helena C. Silva de; Schnitzler, Mariane C.; Schnitzler, Danielle Caroline; Carneiro, Pedro Gontijo; Cestari, Marta Margarete

doi:10.1016/j.ecoenv.2017.12.034

Cited by 61 publications

(18 citation statements)

References 47 publications

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“…Apart from using zebrafish as an in vivo model system, in addition to the zebrafish embryo model that can be regarded as an in vitro method, the use of zebrafish cultured cell lines in genetic toxicology is also on the rise [91,[97][98][99][100][101]. Up to now there have been more than 100 papers describing the zebrafish model both in vivo and in vitro using the comet assay for the assessment of different physical and/or chemical agents such as gamma rays [102,103], X-rays [104], pesticides [105], insecticides [106], fungicides [88,107], herbicides [108], mycotoxins [109], pharmaceuticals [98,99,[110][111][112], heavy metals A c c e p t e d M a n u s c r i p t 9 [108,113,114], PAHs [89], nanoparticles [115][116][117][118], flame retardants [119], sewage effluent [120], waste material [121] as well as model toxicants such as benzo(a)pyrene (B[a]P), methyl methanesulfonate (MMS) and ethyl methanesulfonate (EMS) [122,123].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

The comet assay in animal models: From bugs to whales – (Part 2 Vertebrates)

Gajski

Žegura

Ladeira

et al. 2019

Mutation Research/Reviews in Mutation Research

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The comet assay has become one of the methods of choice for the evaluation and measurement of DNA damage. It is sensitive, quick to perform and relatively affordable for the evaluation of DNA damage and repair at the level of individual cells. The comet assay can be applied to virtually any cell type derived from different organs and tissues. Even though the comet assay is predominantly used on human cells, the application of the assay for the evaluation of DNA damage in yeast, plant and animal cells is also quite high, especially in terms of biomonitoring. The present extensive overview on the usage of the comet assay in animal models will cover both terrestrial and water environments. The first part of the review was focused on studies describing the comet assay applied in invertebrates. The second part of the review, (Part 2) will discuss the application of the comet assay in vertebrates covering cyclostomata, fishes, amphibians, reptiles, birds and mammals, in addition to chordates that are regarded as a transitional form towards vertebrates. Besides numerous vertebrate species, the assay is also performed on a range of cells, which includes blood, liver, kidney, brain, gill, bone marrow and sperm cells. These cells are readily used for the evaluation of a wide spectrum of genotoxic agents both in vitro and in vivo. Moreover, the use of vertebrate models and their role in environmental biomonitoring will also be discussed as well as the comparison of the use of the comet assay in vertebrate and human models in line with ethical principles. Although the comet assay in vertebrates is most commonly used in laboratory animals such as mice, rats and lately zebrafish, this paper will only briefly review its use regarding laboratory animal models and rather give special emphasis to the increasing usage of the assay in domestic and wildlife animals as well as in various ecotoxicological studies.

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Section: Accepted Manuscriptmentioning

confidence: 99%

The comet assay in animal models: From bugs to whales – (Part 2 Vertebrates)

Gajski

Žegura

Ladeira

et al. 2019

Mutation Research/Reviews in Mutation Research

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“…Based on scientific literature [7,13,[22][23][24][25][26][27] a number of research studies have identified the effect of various nanoparticles on hydroceles, the high biological activity of some of the metals' nanoparticles, the acceleration of metabolism and the increased resistance of the organism to natural factors, growth rate and exterior symptoms. It has been noted that in addition to the high bactericidal properties of metals in the form of nanoparticles, it also has less toxicity and are not accumulated in the body because they are used as microelements in the metabolism process [28].…”

Section: Discussionmentioning

confidence: 99%

Influence of Nanoparticles on the Yield of Embryos of the Roe Rainbow Trout (Oncorhynchus mykiss Walbaum) in the Fermentation Process

Ahmadov¹,

Sadıqova²,

Agayeva³

et al. 2018

J Oceanogr Mar Res

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“…Moreover, it was reported that NPs can enter the environment during their manufacturing, utilization, and disposal [ 16 ]. A large and growing body of literature has investigated the aquatic toxicity of carbon nanotubes [ 17 , 18 ], carbon nanofibers [ 19 ], silicon NPs [ 20 ], and metal-based NPs [ 21 , 22 ] in different model organisms. However, it is still difficult to understand the mechanisms of toxicity and behavior of different types of nanomaterials in aquatic systems.…”

Section: Introductionmentioning

confidence: 99%

Toxicity of Carbon, Silicon, and Metal-Based Nanoparticles to Sea Urchin Strongylocentrotus intermedius

et al. 2020

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With the increasing annual production of nanoparticles (NPs), the risks of their harmful influence on the environment and human health are rising. However, our knowledge about the mechanisms of interaction between NPs and living organisms is limited. Prior studies have shown that echinoderms, and especially sea urchins, represent one of the most suitable models for risk assessment in environmental nanotoxicology. To the best of the authors’ knowledge, the sea urchin Strongylocentrotus intermedius has not been used for testing the toxicity of NPs. The present study was designed to determine the effect of 10 types of common NPs on spermatozoa activity, egg fertilization, and early stage of embryo development of the sea urchin S. intermedius. In this research, we used two types of multiwalled carbon nanotubes (CNT-1 and CNT-2), two types of carbon nanofibers (CNF-1 and CNF-2), two types of silicon nanotubes (SNT-1 and SNT-2), nanocrystals of cadmium and zinc sulfides (CdS and ZnS), gold NPs (Au), and titanium dioxide NPs (TiO2). The results of the embryotoxicity test showed the following trend in the toxicity level of used NPs: Au > SNT-2 > SNT-1 > CdS > ZnS > CNF-2 > CNF-1 > TiO2 > CNT-1 > CNT-2. This research confirmed that the sea urchin S. intermedius can be considered as a sensitive and stable test model in marine nanotoxicology.

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Evaluation of multiwalled carbon nanotubes toxicity in two fish species

Cited by 61 publications

References 47 publications

The comet assay in animal models: From bugs to whales – (Part 2 Vertebrates)

The comet assay in animal models: From bugs to whales – (Part 2 Vertebrates)

Influence of Nanoparticles on the Yield of Embryos of the Roe Rainbow Trout (Oncorhynchus mykiss Walbaum) in the Fermentation Process

Toxicity of Carbon, Silicon, and Metal-Based Nanoparticles to Sea Urchin Strongylocentrotus intermedius

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