Evaluation of multiple antibiotic resistance (MAR) index and Doxycycline susceptibility of Acinetobacter species among inpatients

Sandhu, Raminder

doi:10.1016/j.ijid.2016.02.710

Cited by 20 publications

(24 citation statements)

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“…The MAR indices for the human pathogenic bacteria are depicted in Figure 1. As has been reported by Sandhu et al (2016), the majority of the clinical isolates of Acinetobacter had resistance to cotrimoxazole, Cp, Gm, Ak, A/S, cefepime, Im, Mp, with overall MAR indices of 0.3 -1.0 for the isolates. Subramani et al (2012) reported high MAR indices (0.64 -0.74) among Staphylococcus aureus isolates from clinical settings demonstrating the origin of the bacteria from niches with high antibiotic exposure/contamination.…”

Section: Resultssupporting

confidence: 74%

Heavy metal tolerance in association with plasmid mediated multiple antibiotic resistances among clinical bacterial isolates

Das¹,

Mandal²,

Mandal³

2018

Biosci. Biotech. Res. Comm

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The heavy metal tolerance in association with plasmid mediated antibiotic resistance among bacteria has been reported around the globe. This communication conducted an experiment to explore the coexistence of antibiotic resistance and heavy metal tolerance in clinical bacteria and the involvement of R-plasmid in such phenomenon. By disc diffusion method, 6 clinical bacteria: Escherichia coli (n=3), Pseudomonas aeruginosa (n=2) and Proteus mirabilis (n=1), utilized in the study, displayed resistance to multiple antibiotics with MAR (multiple antibiotic resistance) indices 0.15-0.77; such bacterial isolates showed tolerance to Hg 2+ , Cd 2+ , Cr 6+ and Cu 2+ at 3-37.5 μg/ml, 75-800 μg/ml, 100-400 μg/ ml and 600-900 μg/ml, respectively. The SDS treatment induced the test bacteria to mislay their resistance property (following susceptibility test) with a parallel loss of single plasmid (following agarose gel electrophoretic analysis) contained in them. This study confi rms the antibiotic co-resistance with heavy metal tolerance among human pathogenic bacteria, and underlines the regular vigilance of bacterial R-plasmid in order to combat the multiple antibiotic resistances of such bacteria as well as the infection caused by them.

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Section: Resultssupporting

confidence: 74%

Heavy metal tolerance in association with plasmid mediated multiple antibiotic resistances among clinical bacterial isolates

Das¹,

Mandal²,

Mandal³

2018

Biosci. Biotech. Res. Comm

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“…Such an analysis gives an idea of the number of bacteria showing antibiotic resistance in the risk zone of the susceptibility study [19]. In low resource settings, antibiogram along with MAR index serve an important epidemiological tool to monitor drug resistance in bacterial species among inpatients as it is becoming more difficult to treat these pathogens due to the restricted pharmaceutical and therapeutic armamentarium [20].…”

Section: Resultsmentioning

confidence: 99%

“…Similarly, the S. aureus isolates exhibit MAR index ranged between (0.0 -0.7), while MAR index of other Staphylococci was (0.0 -0.6), moreover, the value was (0.0 and 0.0 -0.3) for both of S. agalactiae and E. faecalis respectively. In the study of Sandhu et al 2016 [5], about 3.2% of Acinetobacter spp. had MAR index of 1.0 and 83 of isolates (total number = 93) had MAR index equal or greater than 0.2.…”

Section: Antibioticsmentioning

confidence: 91%

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Assessment of antibiotic sensitivity of the bacterial isolates from patients with bacteremia in Al-Sader Teaching hospital in Amara – Iraq

Abdullah¹,

Al-Ramdhan²,

Thamer³

2020

Proceedings of the Proceedings of the 1st International Multi-Disciplinary Conference Theme: Sustainable Development and Smart

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To investigate the incidence of blood-borne infection and to diagnose the causative bacteria and antibiotic sensitivity. Materials.10 ml of venous blood from (287) febrile patients were collected and subjected to bacterial diagnosis and antibiotic sensitivity test by using Vitek2 tools. Results showed that the incidence of bloodstream infection (BSI) was (54.49%) and infections were higher in adults and males than children and females. Ten Gram-negative and six Gram-positive bacterial isolates were recovered from positive blood cultures. Antibiotic sensitivity testing of the isolates revealed that vancomycin is the most effective antibiotic against gram-positive isolates while erythromycin is the weakest one. Furthermore, both of imipenem and meropenem exhibit the highest activity against gram-negative isolates, whereas piperacillin and trimethoprim/sulfamethoxazole represent the weakest two. Four Gram-negative isolates were found to resist all antibiotics (MAR index value = 1). In conclusion: Staphylococcus aureus and E .coli are still the most prevalent pathogenic bacteria responsible for bacteremia. Despite the high MAR index values of some isolated species, vancomycin, imipenem, and meropenem found to be the most effective antibiotics against Grampositive isolates and Gram-negative, so it is recommended that these antibiotics could be used empirically, at least in the case where this study was conducted, before performing the culture and antibiogram processes.

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“…The Multiple Antibiotic Resistance (MAR) index MAR (Multiple antibiotic resistance) index provides useful information for the evaluation of a health risks [13]. MAR index value higher than 0.2 is regarded as MDR.…”

Section: Antibiotic Susceptibility Testsmentioning

confidence: 99%

High Prevalence of Antimicrobial Resistance among Gram Negative Bacteria Isolated from Poultry

Elmanama

Al-Reefi

Albayoumi

et al. 2018

int. arab. j antimicrob. agents

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Background: Multidrug resistant bacteria (MDR), such as Escherichia coli and Salmonella spp. are threat to the human health care system. In recent years, these MDR bacteria have been found increasingly inside and outside the hospital environment. Food animals (meat and poultry) are increasingly colonized with MDR bacteria, thus posing an additional concern. This study is intended to determine susceptibility and resistance pattern of pathogenic Gram negative bacteria isolated from rectal swabs of chicken against 16 antibiotics. Methods: A total of 216 cloacal swab samples (Gaza strip poultry farms) and 87 frozen and fresh meat samples (from slaughter houses and retails) from June 2017 to June 2018 were collected. Isolation and identification of organisms were achieved using standard bacteriological techniques. Antimicrobial susceptibility test was performed according to standard protocols. Results: 360 Enterobacteriaceae isolates, and 56 Gram-negative non fermenter were recovered. The predominant Enterobacteriaceae isolate was Citrobacter spp. (22.6%), followed by Enterobacter spp. (17.6%) and E. coli (16.5%). High rates of resistance against Ampicillin (85.4%) and Trimethoprim/ Sulfamethoxazole (80.1%) followed by Chloramphenicol (74%) were recorded. Six samples were positive for Salmonella spp. and Shigella spp. Of the tested Enterobacteriacae isolates, 94.7% were multidrug resistant (MDR), and 31.4% of None fermenting bacilli (NFB) were MDR. Carbapenem resistance was found to be high among isolates; 51.9% for imipenem and 1.8% for meropenem. Conclusion: Isolated bacteria in the study area were MDR and this suggests that chickens may be important reservoir of antimicrobial resistant organisms which is a major public health concern.

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Evaluation of multiple antibiotic resistance (MAR) index and Doxycycline susceptibility of Acinetobacter species among inpatients

Cited by 20 publications

References 0 publications

Heavy metal tolerance in association with plasmid mediated multiple antibiotic resistances among clinical bacterial isolates

Heavy metal tolerance in association with plasmid mediated multiple antibiotic resistances among clinical bacterial isolates

Assessment of antibiotic sensitivity of the bacterial isolates from patients with bacteremia in Al-Sader Teaching hospital in Amara – Iraq

High Prevalence of Antimicrobial Resistance among Gram Negative Bacteria Isolated from Poultry

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