This paper describes an effort to optimize the design of an entire space launch vehicle to low-Earth (circular) orbit, consisting of multiple stages using a genetic algorithm (GA) with the goal of minimizing vehicle weight and ultimately vehicle cost. The entire launch vehicle system is analyzed using various multistage configurations to reach low-Earth orbit. Specifically, three and four-stage solid propellant vehicles have been analyzed. The vehicle performance modeling requires that analysis from four separate disciplines be integrated into the design optimization process. The disciplines of propulsion characteristics, aerodynamics, mass properties and flight dynamics have been integrated to produce a high fidelity system model of the entire vehicle. In addition, the system model has been validated using existing launch vehicle data. The cost model is mass-based and uses extensive historical data to produce a cost estimating relationship for a solid propellant vehicle. For the design optimization, the goals of the problem are for the GA to minimize the differences between the desired and actual orbital parameters. This ensures the payload achieves the desired orbit. One final goal is to minimize the overall vehicle mass thus minimizing the system cost per launch. The paper will represent the first effort of its kind to minimize solid propellant launch vehicle cost at the preliminary design level using a GA.