Abstract:Purpose — Cocaine use disorder (CUD) is a complex disease. Some suggest that multi-target drugs could be useful in the treatment of cocaine use disorder. Several studies have shown the efficacy of various multi-target-target drugs used in clinical studies to treat CUD; which integrate into their pharmacological profile the simultaneous NE or 5-HT receptors antagonism or agonism. However, the results of these studies have not shown results consistently. Thus, this study aimed to compare the efficacy of various … Show more
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