Evaluation of mucin expression patterns in gastric borderline (group III) lesions

Abstract

Immunostaining of forceps biopsy samples for the mucin phenotype may be helpful for diagnosing gastric borderline (group III) lesions.

Unclassified mucin phenotype of gastric adenocarcinoma exhibits the highest invasiveness

“…This suggests that differentiated‐type gastric carcinomas, which approximate the intestinal type of Lauren's classification, exhibit phenotypic properties associated with mucin expression. The intestinal mucin phenotype is related to adenomas as well as to differentiated adenocarcinomas 10,11 . In contrast, adenocarcinomas showing gastric mucin expression are related to undifferentiated or diffuse gastric cancer 6,12,13 .…”

“…The intestinal mucin phenotype is related to adenomas as well as to differentiated adenocarcinomas. 10,11 In contrast, adenocarcinomas showing gastric mucin expression are related to undifferentiated or diffuse gastric cancer. 6,12,13 These reports are consistent with our study that the gastric mucin phenotype was more common in poorly differentiated adenocarcinomas and in signet ring cell carcinomas.…”

Differential expression of basement membrane type IV collagen α chains in gastric intramucosal neoplastic lesions

“…Therefore, several immunohistochemical factors have been reported to clarify the criteria for diagnosing carcinoma, including p53, Ki-67, and the mucin phenotype. 28,31,32 We propose that α5/α6(IV) chain expression may be another diagnostic marker of carcinoma in GINL.…”

Risk factors in malignant transformation of gastric epithelial neoplasia categorized by the revised Vienna classification: endoscopic, pathological, and immunophenotypic features

“…Therefore, it is diffi cult for clinicians to determine which low-grade adenomas will progress. To date, only a few studies have determined the risk factors for malignant transformation of gastric epithelial dysplasias, stratifi ed by subgroups specifi c for the dysplastic grade [10,11]. The goal of the present study was to compare the endoscopic fi ndings, pathology of the surrounding mucosa, and the immunophenotype of category 3 lesions (low-grade dysplasia) with these fi ndings in category 4 (high-grade dysplasia and intramucosal cancer) lesions, according to the revised Vienna classifi cation.…”