Evaluation of MUC1, CK20, and hTERT expression in peripheral blood of gastrointestinal cancer patients in search of diagnostic criteria

Küçükyıldırım, Sibel; Erdem, Beril; Saglar, Emel; Polat, Zülfıkar; Mergen, Hatıce

doi:10.3906/biy-1403-73

Cited by 2 publications

(5 citation statements)

References 54 publications

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“…Our results highlighted that MUC1 and MUC5AC mRNA and protein levels were notably up-regulated in tumor tissues when compared with the normal mucosa. A similar pattern was found in many other studies [2,10,15,23].…”

Section: Discussionsupporting

confidence: 91%

“…This variability may be attributed to either ethnicity and geographical distribution or to the heterogeneous designs of these studies (number of samples, sampling methods, tumor sites, tumor stages…) [2].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies pointed out MUC1 involvement in colorectal carcinomas progression and metastasis development. One of the possible mechanisms is that this mucin acts as a ligand for cell adhesion molecules which é<<<<<<benefits MUC1-expressing circulating tumor cells and helps them adhere to endothelial cells and therefore allowing their migration in secondary sites [2,27].…”

Section: Discussionmentioning

confidence: 99%

“…The mucosal surface of the gastrointestinal tract is covered with mucus secreted by specialized epithelial cells known as goblet cells. This mucus serves to lubricate, hydrate and protect the epithelium against potential hazards [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…Several researches reported an increase of both MUC1 and MUC5AC expression compared to the normal mucosa [2,15].…”

Section: Introductionmentioning

confidence: 99%

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MUC1 and MUC5AC implication in Tunisian colorectal cancer patients

et al. 2021

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Background/aim: Mucins such as MUC1 and MUC5AC are known for their protective and moisturizing role of the intestinal epithelium. Their expression is tightly controlled given their essential role in the normal tissue homeostasis, whereas their deregulation leads to chronic inflammation and even cancer. This study aims to assess the expression profiles of MUC1 and MUC5AC and their implications in colorectal carcinogenesis. Materials and methods: We conducted a retrospective study of 202 patients who underwent colorectal cancer surgery. The expression of MUC1 and MUC5AC was investigated by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR). Statistical analysis of mucins expression pattern along with the patients' clinicopathological criteria was performed by the chi-square test, survival curves were plotted using the Kaplan-Meier product-limit method, and differences between the survival curves were tested using the log-rank test. Results: Expression of both mucins was abnormally high in tumor tissues for either mRNA or protein. MUC1 expression correlated with advanced cancer stages and lymph node metastases either for mRNA (p < 0.016 and p < 0.002 respectively) and protein level (p < 0.006 and p < 0.001 respectively). Whereas MUC5AC expression didn't pinpoint any significant association between the clinicopathological criteria, but patients who expressed MUC5AC showed an increase in overall survival (p < 0.009). Conclusion: The expression of MUC1 might be a poor prognostic biomarker in colorectal cancer and could play a role in tumor transformation and metastasis. However, MUC5AC expression might be a good prognostic in the Tunisian cohort.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Several researches reported an increase of both MUC1 and MUC5AC expression compared to the normal mucosa [2,15].…”

Section: Introductionmentioning

confidence: 99%