Evaluation of MTHFR C677T polymorphism in ischemic and hemorrhagic stroke patients. A case–control study in a Northern Indian population

Somarajan, Bindu I; Kalita, Jayantee; Mittal, Balraj; Misra, Usha Kant

doi:10.1016/j.jns.2011.02.010

Cited by 49 publications

(33 citation statements)

References 33 publications

(33 reference statements)

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“…There is conflicting evidence about the relationship of homocysteine and hemorrhagic stroke with some studies finding raised homocysteine levels in hemorrhagic stroke [23,24], others reporting the same in ischemic stroke [25], and still others finding raised homocysteine in both stroke subtypes [26]. Our finding of raised homocysteine concentrations in hemorrhagic stroke cases adds to the homocysteine-hemorrhagic stroke linkage.…”

Section: Discussionmentioning

confidence: 50%

Serial changes in plasma homocysteine in acute clinical stroke

Bokhari

Butt

Hassan

et al. 2012

Translational Neuroscience

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Section: Discussionmentioning

confidence: 50%

Serial changes in plasma homocysteine in acute clinical stroke

Bokhari

Butt

Hassan

et al. 2012

Translational Neuroscience

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“…After excluding articles that deviated from HWE in controls (Li et al, 2003;Ye et al, 2004;Cai et al, 2005), no substantial variation of I 2 was found in the above-mentioned inherited models based on the tentative categorization of I 2 values (Higgins et al, 2003). The key contributor of the article to this low between-study heterogeneity assessed by the leave-one-out sensitive analysis was by Somarajan et al, (2011). After further excluding this article, low heterogeneity (I 2 < 50%) was found in the inherited models, and the result is not changed.…”

Section: C677t Polymorphism In the Mthfr Gene With Hemorrhagic Strokementioning

confidence: 99%

“…We identified 15 published articles (Zhao et al, 2001;Li et al, 2003;Fang et al, 2004;Hu et al, 2004;Ye et al, 2004;Zhang et al, 2004a;Zhang et al, 2004b;Cai et al, 2005;Dikmen et al, 2006;Sazci et al, 2006;Xiao et al, 2006;Zhang et al, 2008;Ruigrok et al, 2010;Hultdin et al, 2011;Somarajan et al, 2011) that were eligible for this meta-analysis on the relation of the C677T polymorphism in the MTHFR gene to hemorrhagic stroke. All 15 eligible studies were case-control designs.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The key contributor of the article to this low between-study heterogeneity assessed by the leave-one-out sensitive analysis was Somarajan et al (2011). After further excluding this article, low heterogeneity (I 2 < 50%) was found, and the association of the C677T polymorphism in the MTHFR gene to hemorrhagic risk altered only slightly in dominant (OR = 1.611, 95% CI = 1.336-1.942), codominant (OR = 1.500, 95% CI = 1.330-1.692), and recessive (OR = 1.695, 95% CI = 1.409-2.038) models (detailed data shown in Table 2).…”

Section: Sources Of Heterogeneity and Sensitivity Analysismentioning

confidence: 99%

“…No individual study was found to have excessive influence on the pooled effect in the three above-mentioned inherited models before and after excluding the article that deviated from HWE in controls (Li et al, 2003;Ye et al, 2004;Cai et al, 2005), and further, the key contributor (Somarajan et al, 2011) to low between-study heterogeneity.…”

Section: Influence Analysismentioning

confidence: 99%

See 2 more Smart Citations

Association of the C677T Polymorphism in the MTHFR Gene with Hemorrhagic Stroke: A Meta-Analysis

Kang

Zhao

Liu

et al. 2013

Genetic Testing and Molecular Biomarkers

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Aims: We performed a meta-analysis to assess the possible association between the MTHFR gene C677T polymorphism and hemorrhagic stroke. Methods: A comprehensive search was conducted to identify all case-control or cohort design studies of the associations between C677T and HS. The fixed or random effect pooled measure was selected on the basis of a homogeneity test among studies. Heterogeneity among studies was evaluated using the I 2 . Meta-regression and the ''leave-one-out'' sensitive analysis of Patsopoulos et al. were used to explore potential sources of between-study heterogeneity. Publication bias was estimated using the Begg's test. Results: Fifteen case-control studies corresponded to the inclusion criteria, including 2034 cases and 4485 controls for the present meta-analysis. After excluding articles that deviated from the Hardy-Weinberg equilibrium in controls and the key contributors to between-study heterogeneity, significant associations between the MTHFR C677T genetic polymorphism and the risk of hemorrhagic stroke were observed in dominant (Odds ratio [OR] 1.611, 95% confidence interval [CI] 1.336-1.942), codominant (OR 1.500, 95% CI 1.330-1.692), and recessive (OR 1.695, 95% CI 1.409-2.038) models. Conclusions: The meta-analysis suggests that the MTHFR C667T genetic polymorphism was associated with increased risk of hemorrhagic stroke, and the T allele may be an important risk factor for hemorrhagic stroke. The findings are of importance to the genetic epidemiology of hemorrhagic stroke, and to explore genetic diagnosis, treatment, and prevention of hemorrhagic stroke.

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Associations of MTRR A66G polymorphism and promoter methylation with ischemic stroke in patients with hyperhomocysteinemia

Zhao

Zhang

et al. 2020

The Journal of Gene Medicine

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Background: Patients with hyperhomocysteinemia (HHcy) have a higher risk of developing ischemic stroke (IS). The association between MTRR A66G polymorphism and promoter methylation with IS in patients with HHcy is also uncertain. The present study aimed to investigate the association between the MTRR polymorphism and methylation with IS in HHcy patients.Methods: This case-control study included a total of 304 HHcy patients (95 with IS and 209 without IS). Multivariate logistic regression analyses were applied to explore the association between MTRR polymorphism and classical atherothrombotic risk factors with the risk of IS.Results: The log-additive and dominant models were markedly different in participants with IS compared to the control group (p = 0.031 and 0.016, respectively). The log-additive and dominant showed a significant association with IS in the low level plasma homocysteine groups (p = 0.024 and 0.014, respectively). No significant difference of methylation between IS and without IS group (p > 0.05). Patients with high plasma homocysteine had a 4.041-4.941 fold higher risk of IS (p = 0.01, 0.016 and 0.041, respectively) compared to the low plasma homocysteine group. Age, diabetes, hypertension and plasma homocysteine were the risk factors for IS in patients with HHcy (p = 0.033, 0.000, 0.001 and 0.038, respectively).Conclusions: MTRR A66G polymorphism and an elevated plasma plasma homocysteine level were significantly associated with an increased risk of IS in patients with HHcy. Age, diabetes, hypertension and Hcy were all found to be associated with IS.

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Evaluation of MTHFR C677T polymorphism in ischemic and hemorrhagic stroke patients. A case–control study in a Northern Indian population

Cited by 49 publications

References 33 publications

Serial changes in plasma homocysteine in acute clinical stroke

Serial changes in plasma homocysteine in acute clinical stroke

Association of the C677T Polymorphism in the MTHFR Gene with Hemorrhagic Stroke: A Meta-Analysis

Associations of MTRR A66G polymorphism and promoter methylation with ischemic stroke in patients with hyperhomocysteinemia

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