Evaluation of Monolayer and Bilayer Buccal Films Containing Metoclopramide
Blaž Grilc,
Odon Planinšek
Abstract:The objective of this study was to develop buccal film formulations containing metoclopramide hydrochloride monohydrate (MCP) with and without a backing layer and to evaluate their release properties and physiochemical stability. The crystallization of MCP in the polymer matrix was monitored with image analysis techniques for rapid and scalable observation. The results showed that the addition of a protective layer and its thickness significantly affected the release rate and crystallization behavior of MCP in… Show more
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