Evaluation of monocyte to high-density lipoprotein ratio, lymphocytes, monocytes, and platelets in psoriasis

Karabay, Ezgi Aktaş; Demіr, Damla; Çerman, Aslı Aksu

doi:10.1016/j.abd.2019.05.002

Cited by 27 publications

(34 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on this view, it is rational to unite these two parameters into a single index (MHR), which is cost-effective and consists of easily available laboratory parameters reflecting anti-inflammatory and antioxidant effects. Recent studies propose a high level of MHR as an unfavorable prognostic marker, indicating systemic inflammatory and oxidative diseases, including Behçet's disease, psoriasis, and spondylarthritis (49)(50)(51). The present study was consistent with the abovementioned clinical observations in that the MHR level was noticed to be significantly higher in the non-survivors group with the average level than the survivor group, which demonstrated MHR was a more precise parameter than others for evaluating systematic inflammation in sepsis.…”

Section: Discussionsupporting

confidence: 91%

Efficiency of Monocyte/High-Density Lipoprotein Cholesterol Ratio Combined With Neutrophil/Lymphocyte Ratio in Predicting 28-Day Mortality in Patients With Sepsis

Yao

Liu

et al. 2021

Front. Med.

View full text Add to dashboard Cite

Background: Sepsis can cause unpredictable harm, and early identification of risk for mortality may be conducive to clinical diagnosis. The present study proposes to assess the efficacy of the monocyte/high-density lipoprotein cholesterol ratio (MHR) combined with the neutrophil/lymphocyte ratio (NLR) on the day of admission in predictive efficacy in the 28-day mortality risk in critical patients with sepsis.Material and Methods: We administered observational and retrospective cohort research from a single center. The correlation of the clinical variables, together with the system severity scores of APACHE II and SOFA, are displayed by correlation analysis, and a Cox regression model could be performed to screen the independent risk factors and estimate the capacity of multiple markers in predicting 28-day mortality. The receiver operating characteristic (ROC) curve served as an applied method to output cutoff values for the diagnosis and prognostic risk, and the area under the ROC curve and net reclassification improvement index (NRI), as well as integrated discrimination improvement index (IDI) were employed to assess the feasibility of multiple parameters for predictive value in 28-day mortality of septic patients.Results: The study enrolled 274 eligible patients with sepsis. The correlation analysis indicated NLR and MHR were related to the sepsis severity. A multivariate Cox regression analysis indicated that NLR together with MHR displayed a close relation to death rate after adjusting for other potential confounders (NLR, HR = 1.404 [95% CI 1.170–1.684], P < 0.001; MHR, HR = 1.217 [95% CI 1.112–1.331], P < 0.001). The AUC of NLR, MHR, NLR_MHR was 0.827, 0.876, and 0.934, respectively. The addition on the biomarker NLR_MHR to the prediction model improved IDI by 18.5% and NRI by 37.8%.Conclusions: Our findings suggest that NLR and MHR trend to an elevated level in non-surviving patients with sepsis. Evaluation of NLR_MHR, an independent risk factor for increased mortality, might improve the predictive efficacy for 28-day mortality risk in septic patients.

show abstract

Section: Discussionsupporting

confidence: 91%

Efficiency of Monocyte/High-Density Lipoprotein Cholesterol Ratio Combined With Neutrophil/Lymphocyte Ratio in Predicting 28-Day Mortality in Patients With Sepsis

Yao

Liu

et al. 2021

Front. Med.

View full text Add to dashboard Cite

show abstract

“…The MHR is a new inflammatory marker that has been used for cardiovascular diseases, tumors and, chronic inflammatory diseases 39‐41 . Aktas Karabay et al 42 found statistically significant difference in MHR between psoriasis patients and control group. Also they reported positive correlation between the psoriasis area and severity index and MHR.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the laboratory parameters in hidradenitis suppurativa: Can we use new inflammatory biomarkers?

Çetinarslan¹,

Ermertcan

Özyurt

et al. 2021

Dermatologic Therapy

View full text Add to dashboard Cite

Hidradenitis suppurativa (HS) is a chronic, recurrent, and debilitating skin disease.Recent studies showed that inflammatory biomarkers, such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), Lymphocyte/HDL ratio (LHR), Neutrophil/HDL ratio (NHR), and Monocyte/HDL ratio (MHR) are an indicator of inflammatory diseases and may be associated with disease severity and disease activity. To investigate NLR, PLR, LHR, NHR, and MHR in HS patients. In addition, to compare erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), complete blood count, leukocyte profile, and biochemical parameters between the control and the patient group. Clinical and biochemical data of patients and healthy subjects were collected from medical records, retrospectively. In total, 166 patients with HS and 124 control subjects were included. We found no significant difference in NLR (P = .207) and PLR (P = .257). LHR (P < .001), NHR (P < .001), and MHR (P < .001) were significantly higher in the patient group. No positive correlation was found between any of these markers and disease severity according to Hurley staging system. However, MCV (Mean corpuscular volume), RDW (Red cell distribution width), and CRP showed a significant positive correlation with disease severity. Among these markers, only MHR was positively correlated with disease duration. Our study shows that CRP still maintains its value for HS patients compared to new inflammation markers. Unlike the studies in other inflammatory diseases, no significant relationship was found with most of these inflammatory parameters. MHR may be more useful in patients with HS as an indicator of inflammation compared to other parameters.

show abstract

“…Atas et al 21 found that ESR, CRP and NLR were statistically higher in patients with lichen planus when compared with the controls. Karabay et al 22 compared the CRP, MHR and CBC parameters in the psoriasis and control group and observed statistically significantly higher CRP, MHR, NLR and MLR values in the psoriasis group compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

Investigation of monocyte HDL ratio as an indicator of inflammation and complete blood count parameters in patients with acne vulgaris

2020

View full text Add to dashboard Cite

Acne vulgaris is a common inflammatory skin disease that affects the pilosebaceous unit. 1 Acne vulgaris affects 9.4% of the world population. It is most common among young people. It is more common among men; however, its prevalence increases with age in women. In male patients, the probability of severe acne is higher when compared with female patients. 2 Increased sebum production, hyperkeratosis in follicular infundibulum, inflammation and Propionibacterium acne (P acne) are among aetiological factors. Acne vulgaris lesions are first seen on the face and thus can affect patients' quality of life negatively. It has been claimed that acne can cause psychological diseases such as anxiety, low self-worth and depression among adolescents and adults. 1 Although its definite pathogenesis is not clear, immune response and inflammatory lesions caused by the P acne infection are considered as important factors. 3,4 Complete blood count is an analytical test with low cost and it is performed with automatic counting devices and it is used routinely. Complete blood count (CBC) parameters are used as diagnosis biomarkers for many diseases related with inflammatory processes.

show abstract

Evaluation of monocyte to high-density lipoprotein ratio, lymphocytes, monocytes, and platelets in psoriasis

Cited by 27 publications

References 29 publications

Efficiency of Monocyte/High-Density Lipoprotein Cholesterol Ratio Combined With Neutrophil/Lymphocyte Ratio in Predicting 28-Day Mortality in Patients With Sepsis

Efficiency of Monocyte/High-Density Lipoprotein Cholesterol Ratio Combined With Neutrophil/Lymphocyte Ratio in Predicting 28-Day Mortality in Patients With Sepsis

Evaluation of the laboratory parameters in hidradenitis suppurativa: Can we use new inflammatory biomarkers?

Investigation of monocyte HDL ratio as an indicator of inflammation and complete blood count parameters in patients with acne vulgaris

Contact Info

Product

Resources

About