Abstract:Lawsonia intracellularis (LI)is an obligate intracellular bacterium that causes proliferative enteropathy (PE) in various species including pigs, horses, rabbits, dogs and hamsters. Infection by LI results in the expansion of proliferative SOX9 positive cells and reduction of enterocytes and goblet cells. In a previous study, RNAseq analysis of laser micro‐dissected ilea of infected pigs showed up‐regulation of ADAMTS1 metallopeptidase which codes for surface proteins with adhesion and protease activity. The i… Show more
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