Evaluation of molecular detection of extrapulmonary tuberculosis and resistance to rifampicin with GeneXpert® MTB/RIF

Marouane, Chama; Smaoui, Salma; Kammoun, S.; Slim, L.; Messadi-Akrout, Férièle

doi:10.1016/j.medmal.2015.10.012

Cited by 15 publications

(13 citation statements)

References 12 publications

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“…In contrast, the sensitivity of PCR for MTB detection in the extrapulmonary specimens was not highly appreciated . For DR‐EPTB detection, there have been few researches demonstrated good concordance between the phenotypic and rapid molecular DST in limit number of EPTB patients . More researches are needed in a large population and various extrapulmonary samples.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and risk factors of drug‐resistant extrapulmonary tuberculosis

Boonsarngsuk

Mangkang

Santanirand

2018

Clinical Respiratory J

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Section: Discussionmentioning

confidence: 99%

Prevalence and risk factors of drug‐resistant extrapulmonary tuberculosis

Boonsarngsuk

Mangkang

Santanirand

2018

Clinical Respiratory J

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“…31 Bunsow E et al support the accuracy and rapidity of the test, but suggest other confirmatory tests for drug resistant mycobacteria. 32 Centre for disease control too recommends combination of tests, in particular for smear negative cases.…”

Section: Discussionmentioning

confidence: 99%

GeneXpert: a game changer in the detection and diagnosis of childhood tuberculosis

Gandra¹,

Gali²

2017

Int J Contemp Pediatr

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Background: Battling against tuberculosis (TB) is still a major challenge in India, despite measures undertaken by the government and medical fraternity. Delay in diagnosing tuberculosis is a challenge, causing hurdle in the prevention of spread of the disease.Methods: This retrospective study analysed the samples by geneXpert assay. Samples (n=403, from 359 children) included pulmonary (sputum and gastric aspirate, 359), extrapulmonary (lymph node aspirate (LNA), 41) cerebrospinal fluid (CSF, 03) pus from the lesion at the elbow joint (01). Only sputum was analysed for 315 children, both sputum and LNA for 41.Results: Mean age of patients was 9.08±2.85 years, range 3-15 years. There were 221 (61.56%) males and 138 (38.44%) females. Fever (71, 19.78%), fever with cough (87, 24.23%), fever with weight loss (41,11.42%) were the main symptoms. There were three patients with high fever, headache and seizures with neck rigidity, clinically diagnosed as Tuberculous meningitis. There was history of contact with Tuberculosis in 15 (4.18%) patients. Mean ESR was 112.09mm/1st Hr±56.05 (range 54 -750 mm/1st Hr). Mantoux test was positive in 270 (75.42%). Chest X-ray was normal in 33 (9.19%); consolidation in 189 (52.65%), mild pleural effusion in 94 (26.18%) mild pleural effusion associated with consolidation in 43 (11.98%) were reported. Positive GeneXpert assay (106 samples, 27.39%; sputum (87, 24.23% %), pus (01), CSF (03), LNA (15, 57.69%) was reported in 87 patients. Results were obtained ≤36 hours, mean 2 hours± 2.34 (range 6- 36 hours).Conclusions: GeneXpert is an effective tool for rapid detection of tuberculosis. Present study supports its inclusion in the battery of routine investigations. It can revolutionise the scenario in prevention and management of tuberculosis.

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“…Tuberculosis (TB) remains one of the biggest health problems in developing and industrialized countries [2] with extrapulmonary tuberculosis (EPT) representing an increasing proportion reaching 20 to 40% [3].…”

Section: Discussionmentioning

confidence: 99%

“…In Tunisia, the incidence of EPT is also on the rise and a growing interest in EPT is observed [3]. The most common site of extrapulmonary disease is lymph node especially the cervical group (60-90%).…”

Section: Discussionmentioning

confidence: 99%

A cervical tuberculous abscess mimicking a fourth branchial cleft cyst in a child: PCR, the key to fast diagnosis

Riahi

Fradi

Jaafoura

et al. 2020

Egypt J Otolaryngol

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Background: Anterior cervical tuberculous abscess is a rare presentation of extrapulmonary tuberculosis even in endemic countries. Case presentation: We report a case of a 14-year-old girl with a 5 day history of an anterior mass. The diagnosis of an infected fourth branchial cleft cyst was first evoked. Fine-needle aspiration cytology was suggestive of tuberculosis. Polymerase chain reaction analysis was the key to the diagnosis of a tuberculous abscess. Conclusions: In endemic countries, abscesses occurring in uncommon sites should be dealt with a high degree of suspicion for tuberculosis. Early diagnosis is essential to initiate specific and effective treatment. Pre-operative diagnosis avoids invasive surgery and related complications.

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Evaluation of molecular detection of extrapulmonary tuberculosis and resistance to rifampicin with GeneXpert® MTB/RIF

Cited by 15 publications

References 12 publications

Prevalence and risk factors of drug‐resistant extrapulmonary tuberculosis

Prevalence and risk factors of drug‐resistant extrapulmonary tuberculosis

GeneXpert: a game changer in the detection and diagnosis of childhood tuberculosis

A cervical tuberculous abscess mimicking a fourth branchial cleft cyst in a child: PCR, the key to fast diagnosis

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