Evaluation of mobile phone radiation-induced structural changes of rat brain with emphasis on the possible protective role of pomegranate peel extract

Abstract

Background:The study aims to evaluate the impact of the antioxidant rich pomegranate fruit grown in Taif on the histological and immunohistochemical changes in the cerebral and cerebellar cortex after different levels of mobile exposure. Materials and Methods: Thirty adult male rats were divided into group I, II, III; IV, and group V. Group I was control and group II rats were exposed to 900 MHz and in group III the rats are exposed to 1800 MHz for two months. Group IV the rats were exposed to 900 MHz concomitant with pomegranate peel extract (500 mg/kg) and group V rats were exposed to 1800 MHz and pomegranate peel extract (500 mg/kg) orally in aqueous solution once per day for two months. Frontal cortex and cerebellum tissues were dissected out and processed for histopathological and immunohistochemical studies. Results: The cerebral and cerebellar cortexes of mobile-exposed rats exhibited degenerative changes especially in the nerve cells. These changes were more pronounced with increase in the frequency of radiation. Most of pyramidal and Purkinje cells became irregular in shape, had deeply stained nuclei, and were surrounded with peri-cellular haloes and vacuolated neuropil. However, some of them were surrounded with neuroglial accumulation. Conclusion: The study concluded that pomegranate peel extract can ameliorate the histopathological changes induced by mobile phone electromagnetic radiations.

Investigation of genetic stress parameters in brain tissues of rats exposed to 1.8 GHz cell phone radiofrequency electromagnetic field

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Pharmacotherapeutic potential of pomegranate in age-related neurological disorders

“…The cerebral and cerebellar cortices of the rats exposed to mobile phone radiation showed degenerative changes, especially in neurons. This study concluded that pomegranate extract can improve histopathological changes induced by cellular electromagnetic radiation (Belal et al, 2020 ). Kandeil et al conducted research on the protective effect of pomegranate peel extract on titanium dioxide nanoparticles.…”

Effect of Electromagnetic Filed (EMF) Equal to that Emitted form Cellular Phones on the Layers of Cerebral Cortex of the Frontal Lobe of Male Albino Rats of Different Ages

“…With higher EMR (1800MHZ) animals showed more severe degeneration in nerve cells, vacuolated neuropil in all layers and congestion in many blood vessels. 23 Congestion in the vessels and RBCs extravasation in a myocardial study, may be due to free radical generation with EMF. 24 In recovery groups (III) pyramidal or granular cells showed approximately normal appearance this can be supported by persistent appearance of newborn cortical neurons after stroke.…”