Evaluation of Mitochondrial Respiratory Chain on the Generation of Reactive Oxygen Species and Cytotoxicity in HaCaT Cells Induced by Nanosized Titanium Dioxide Under UVA Irradiation

Xue, Chengbin; Li, Xiaonan; Liu, Guozhen; Liu, Wei

doi:10.1177/1091581816661853

Cited by 21 publications

(14 citation statements)

References 40 publications

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“…Mitochondria can control this fact by converting them into H 2 O 2 by superoxide dismutase (SOD), and finally into water by glutathione peroxidase and catalase [71]. The presence of TiO 2 NPs increases the production of ROS at levels that this enzymatic defense mechanism cannot attenuate the damage, even a dysregulation in electron transfer through the mitochondrial respiratory chain implies an increase in ROS generation [72].…”

Section: Inhibition Of Respiratory Chainmentioning

confidence: 99%

Antimicrobial Effect of Titanium Dioxide Nanoparticles

Dicastillo¹,

Correa²,

Martínez³

et al. 2021

Antimicrobial Resistance - A One Health Perspective

108

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The widespread use of antibiotics has led to the emergence of multidrugresistant bacterial strains, and therefore a current concern for food safety and human health. The interest for new antimicrobial substances has been focused toward metal oxide nanoparticles. Specifically, titanium dioxide (TiO 2) has been considered as an attractive antimicrobial compound due to its photocatalytic nature and because it is a chemically stable, non-toxic, inexpensive, and Generally Recognized as Safe (GRAS) substance. Several studies have revealed this metal oxide demonstrates excellent antifungal and antibacterial properties against a broad range of both Gram-positive and Gram-negative bacteria. These properties were significantly improved by titanium dioxide nanoparticles (TiO 2 NPs) synthesis. In this chapter, latest developments on routes of synthesis of TiO 2 NPs and antimicrobial activity of these nanostructures are presented. Furthermore, TiO 2 NPs favor the inactivation of microorganisms due to their strong oxidizing power by free radical generation, such as hydroxyl and superoxide anion radicals, showing reductions growth against several microorganisms, such as Escherichia coli and Staphylococcus aureus. Understanding the main mechanisms of antimicrobial action of these nanoparticles was the second main purpose of this chapter.

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Section: Inhibition Of Respiratory Chainmentioning

confidence: 99%

Antimicrobial Effect of Titanium Dioxide Nanoparticles

Dicastillo¹,

Correa²,

Martínez³

et al. 2021

Antimicrobial Resistance - A One Health Perspective

108

View full text Add to dashboard Cite

show abstract

“…Simultaneously, UVR-induced photoactivation of some metal nanomaterials can facilitate their penetration of the skin. In vitro , UVR-induced ROS production by TiO 2 NP, QD, and ZnO NP has been associated with DNA damage, lipid peroxidation, and mitochondrial permeability in skin cells (Tiano et al 2010; Wang et al 2013; Petersen et al 2014; Mortensen et al 2015; Xue et al 2015, 2016). Subsequent cytotoxicity to dermal fibroblasts, keratinocytes, and melanocytes is another mechanism by which skin barrier integrity can become compromised as a result of UVR.…”

Section: Metal Nanomaterials and Dermal Hypersensitivitymentioning

confidence: 99%

Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease

Roach

Stefaniak

Roberts

2019

Journal of Immunotoxicology

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The recent surge in incorporation of metallic and metal oxide nanomaterials into consumer products and their corresponding use in occupational settings have raised concerns over the potential for metals to induce size-specific adverse toxicological effects. Although nano-metals have been shown to induce greater lung injury and inflammation than their larger metal counterparts, their size-related effects on the immune system and allergic disease remain largely unknown. This knowledge gap is particularly concerning since metals are historically recognized as common inducers of allergic contact dermatitis, occupational asthma, and allergic adjuvancy. The investigation into the potential for adverse immune effects following exposure to metal nanomaterials is becoming an area of scientific interest since these characteristically lightweight materials are easily aerosolized and inhaled, and their small size may allow for penetration of the skin, which may promote unique size-specific immune effects with implications for allergic disease. Additionally, alterations in physicochemical properties of metals in the nano-scale greatly influence their interactions with components of biological systems, potentially leading to implications for inducing or exacerbating allergic disease. Although some research has been directed toward addressing these concerns, many aspects of metal nanomaterial-induced immune effects remain unclear. Overall, more scientific knowledge exists in regards to the potential for metal nanomaterials to exacerbate allergic disease than to their potential to induce allergic disease. Furthermore, effects of metal nanomaterial exposure on respiratory allergy have been more thoroughly-characterized than their potential influence on dermal allergy. Current knowledge regarding metal nanomaterials and their potential to induce/ exacerbate dermal and respiratory allergy are summarized in this review. In addition, an examination of several remaining knowledge gaps and considerations for future studies is provided.

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“…It is the only enzyme that participates in both the citric acid cycle and the electron transport chain (ETC). [57][58][59][60] Fig. 9 shows that after 15 minutes of incubation of mitochondrial suspension with 0Fe/Ti (TiO 2 ), a concentration-dependent decrease of optical density (OD) at 570 nm appeared and the activity of succinate dehydrogenase (complex II) gets reduced.…”

Section: Activity Of Respiratory Chain Complex IImentioning

confidence: 99%

Study of mitochondrial swelling, membrane fluidity and ROS production induced by nano-TiO2 and prevented by Fe incorporation

Barkhade

Mahapatra

Banerjee

2019

Toxicology Research

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The potential impact of TiO2 and Fe incorporated TiO2 nanoparticles at the organelle level has been reported. The toxicity of the samples on mitochondria isolated from chicken liver tissue has been examined through mitochondrial swelling, membrane fluidity, ROS generation capacity, and activity of complex II. The toxic effect of TiO2 was prevented by incorporating Fe into the TiO2 matrix at different concentrations. The activity of the succinate dehydrogenase enzyme complex was affected and permeabilization of the mitochondrial inner membrane to H+ and K+ and its alteration in membrane fluidity at 100 μg mL−1 of nano-TiO2 dosage were investigated, which showed significant changes in the anisotropy of DPH-labeled mitochondria. Fe incorporation into the TiO2 matrix makes it more biocompatible by changing its structure and morphology.

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Evaluation of Mitochondrial Respiratory Chain on the Generation of Reactive Oxygen Species and Cytotoxicity in HaCaT Cells Induced by Nanosized Titanium Dioxide Under UVA Irradiation

Cited by 21 publications

References 40 publications

Antimicrobial Effect of Titanium Dioxide Nanoparticles

Antimicrobial Effect of Titanium Dioxide Nanoparticles

Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease

Study of mitochondrial swelling, membrane fluidity and ROS production induced by nano-TiO2 and prevented by Fe incorporation

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