2016
DOI: 10.1177/1091581816661853
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Evaluation of Mitochondrial Respiratory Chain on the Generation of Reactive Oxygen Species and Cytotoxicity in HaCaT Cells Induced by Nanosized Titanium Dioxide Under UVA Irradiation

Abstract: Nanosized titanium dioxide (nano-TiO) is widely used in the chemical, electrical, and electronic industries. Nanosized TiO has been reported to be an efficient photocatalyst, which is able to produce reactive oxygen species (ROS) under UVA irradiation. In the present work, we evaluate the effect of mitochondrial respiratory chain on the generation of ROS and cytotoxicity in keratinocyte (HaCaT) cells induced by nano-TiO under UVA irradiation. HaCaT cells were pretreated with different inhibitors of mitochondri… Show more

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Cited by 21 publications
(14 citation statements)
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“…Mitochondria can control this fact by converting them into H 2 O 2 by superoxide dismutase (SOD), and finally into water by glutathione peroxidase and catalase [71]. The presence of TiO 2 NPs increases the production of ROS at levels that this enzymatic defense mechanism cannot attenuate the damage, even a dysregulation in electron transfer through the mitochondrial respiratory chain implies an increase in ROS generation [72].…”
Section: Inhibition Of Respiratory Chainmentioning
confidence: 99%
“…Mitochondria can control this fact by converting them into H 2 O 2 by superoxide dismutase (SOD), and finally into water by glutathione peroxidase and catalase [71]. The presence of TiO 2 NPs increases the production of ROS at levels that this enzymatic defense mechanism cannot attenuate the damage, even a dysregulation in electron transfer through the mitochondrial respiratory chain implies an increase in ROS generation [72].…”
Section: Inhibition Of Respiratory Chainmentioning
confidence: 99%
“…Simultaneously, UVR-induced photoactivation of some metal nanomaterials can facilitate their penetration of the skin. In vitro , UVR-induced ROS production by TiO 2 NP, QD, and ZnO NP has been associated with DNA damage, lipid peroxidation, and mitochondrial permeability in skin cells (Tiano et al 2010; Wang et al 2013; Petersen et al 2014; Mortensen et al 2015; Xue et al 2015, 2016). Subsequent cytotoxicity to dermal fibroblasts, keratinocytes, and melanocytes is another mechanism by which skin barrier integrity can become compromised as a result of UVR.…”
Section: Metal Nanomaterials and Dermal Hypersensitivitymentioning
confidence: 99%
“…It is the only enzyme that participates in both the citric acid cycle and the electron transport chain (ETC). [57][58][59][60] Fig. 9 shows that after 15 minutes of incubation of mitochondrial suspension with 0Fe/Ti (TiO 2 ), a concentration-dependent decrease of optical density (OD) at 570 nm appeared and the activity of succinate dehydrogenase (complex II) gets reduced.…”
Section: Activity Of Respiratory Chain Complex IImentioning
confidence: 99%