Evaluation of Mineral Concentrations in Maternal Serum Before and After Birth and in Newborn Cord Blood Postpartum—Preliminary Study

Kocyłowski, Rafał; Lewicka, Iwona; Grzesiak, Mariusz; Gaj, Zuzanna; Oszukowski, Przemysław; Kaisenberg, Constantin von; Suliburska, Joanna

doi:10.1007/s12011-017-1109-9

Cited by 17 publications

(9 citation statements)

References 24 publications

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“…Interestingly, the concentration of this microelement was 31 times lower in the AF than in the serum. In accordance with other data, our previous study [ 4 ] showed that Cu concentration in the blood of pregnant women was significantly higher than in non-pregnant women and increased during the course of the pregnancy [ 4 , 15 , 17 , 20 – 22 ]. It is suggested that the Cu level is related to the increase in blood estrogen levels, which mobilizes Cu stores from tissues.…”

Section: Discussionsupporting

confidence: 91%

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Evaluation of Essential and Toxic Elements in Amniotic Fluid and Maternal Serum at Birth

Kocyłowski

Grzesiak

Gaj

et al. 2018

Biol Trace Elem Res

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The objective of this study was to determine the concentration and the reference ranges of essential and toxic elements in amniotic fluid (AF) and maternal serum (MS) at birth. This study was conducted among 175 healthy pregnant Caucasian European women aged 18-42. AF and maternal blood samples were collected during delivery. An inductively coupled plasma mass spectrometry (ICP-MS) technique was used to determine the levels of Mg, Co, Cu, Zn, Sr, Cd, Ba, Pb, U, Ca, Cr, Al, Mn, V, Fe, As, Se and Sb in AF and MS. The range of reference values was calculated for all analyzed elements in the serum and AF. The mean concentrations of elements, except Pb, were generally higher in MS than in AF. Multiple regression analysis showed that the maternal/newborn body mass (MBM/NBM) ratio was a strong negative predictor (among maternal age and gravidity) of Mg concentration in amniotic fluid. In the serum, MBN/NBM ratio was a strong positive predictor of Cu concentration. Moreover, regression analysis showed that maternal age was an independent positive predictor of the Se level in maternal serum. The reference value ranges of 18 essential and toxic elements were established in AF and MS among a population of healthy pregnant Polish women at delivery. The level of Mg, Co, Cu, Ca and Se in AF and MS can be determined by maternal age and MBM/NBM ratio. These results can be useful in counseling individuals with pregnancies affected by exposure to one of the parameters under investigation.

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Section: Discussionsupporting

confidence: 91%

“…The demand for some trace elements increases during pregnancy [ 1 ]. Therefore, a deficiency in some minerals is often observed among pregnant women [ 1 , 4 , 5 ]. Inadequate quantities of micro- and macro-minerals as well as overexposure to toxic elements could be detrimental to the health of both the pregnant woman and the fetus.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Essential and Toxic Elements in Amniotic Fluid and Maternal Serum at Birth

Kocyłowski

Grzesiak

Gaj

et al. 2018

Biol Trace Elem Res

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“…Published data from pregnant women are presented in Table S1 . In those studies, mean sMg concentration in mothers ranged from 0.59 mmol/L to 0.95 mmol/L during gestation [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ], from 0.54 mmol/L to 0.86 mmol/L before or during labor [ 31 , 35 , 40 , 41 , 43 , 46 , 47 , 48 , 49 ], and from 0.54 mmol/L to 0.90 mmol/L at delivery [ 24 , 35 , 36 , 42 , 48 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ].…”

Section: Resultsmentioning

confidence: 99%

“…In addition, data on sMg levels in cord blood and during the early neonatal period are available in preterm infants included in randomized control trials evaluating the effect of maternal magnesium administration before delivery for tocolysis, for prevention or treatment of eclampsia, or for neuroprotection against cerebral palsy. In these studies, the control group may represent normative neonatal levels whereas the treatment group may be evaluated to discern upper tolerable levels or potential side effects of magnesium overload ( Table S2 ; Figure 2 ) [ 24 , 34 , 35 , 40 , 41 , 42 , 43 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 57 , 58 , 59 , 60 , 63 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 ].…”

Section: Resultsmentioning

confidence: 99%

Serum Magnesium Levels in Preterm Infants Are Higher Than Adult Levels: A Systematic Literature Review and Meta-Analysis

et al. 2017

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Magnesium (Mg) is an essential mineral in the body, impacting the synthesis of biomacromolecules, bone matrix development, energy production, as well as heart, nerve, and muscle function. Although the importance of Mg is evident, reference values for serum Mg (sMg) in pediatric patients (more specifically, in neonates) are not well established. This systematic literature review and meta-analysis (using 47 eligible studies) aims to quantify normal and tolerable ranges of sMg concentrations during the neonatal period and to highlight the factors influencing Mg levels and the importance of regulating sMg levels during pregnancy and birth. In newborns without Mg supplementation during pregnancy, magnesium levels at birth (0.76 (95% CI: 0.52, 0.99) mmol/L) were similar to that of mothers during pregnancy (0.74 (95% CI: 0.43, 1.04) mmol/L), but increased during the first week of life (0.91 (95% CI: 0.55, 1.26) mmol/L) before returning to adult levels. This pattern was also seen in newborns with Mg supplementation during pregnancy, where the average was 1.29 (95% CI: 0.50, 2.08) mmol/L at birth and 1.44 (95% CI: 0.61, 2.27) mmol/L during the first week of life. Factors influencing these levels include prenatal Mg supplementation, gestational age, birth weight, renal maturity/function, and postnatal Mg intake. Elevated Mg levels (>2.5 mmol/L) have been associated with an increased risk of mortality, admission into intensive care, hypotonia, hypotension, and respiratory depression but sMg concentrations up to 2.0 mmol/L appear to be well tolerated in neonates, requiring adequate survey and minimal intervention.

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“…In one of our previous studies, we observed that magnesium concentration in amniotic fluid (AF) decreased as the pregnancy proceeded and we also found a negative correlation between magnesium in AF and foetal growth parameters [ 42 ]. We also observed lower magnesium concentration in AF in older women (> 35 years old) than in younger ones [ 41 ], however, we did not observe a relation between the age of women and magnesium content in cord blood after delivery [ 43 ]. This study shows that the content of zinc in hair samples was significantly lower in older women than in younger (< 35 years old) without significant differences in zinc supply between these groups (Table 7 ).…”

Section: Discussionmentioning

confidence: 96%

Assessment of dietary intake and mineral status in pregnant women

Kocyłowski

Lewicka

Grzesiak

et al. 2018

Arch Gynecol Obstet

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PurposeTo evaluate the dietary intake of pregnant women and their nutritional status of Ca, Mg, Fe, Zn, and Cu, as the nutritional status of pregnant women is an important factor for the proper progression of a pregnancy and the development and health of the foetus.MethodsThe study was conducted on 108 pregnant women ages 18–42, at 6–32 weeks of gestation. We used a questionnaire and a 24-h recall nutrition interview. Hair samples were taken for testing and the level of each mineral was assessed using atomic absorption spectrometry. The results were analysed using the Dietetyk and Statistica 10 software.ResultsLow levels of Fe, Zn, Ca, Mg, vitamin D, and folic acid intake were seen in the pregnant women, with the use of dietary supplements significantly increasing their intake of Fe, Zn, and folic acid. The concentration of zinc and magnesium in the women’s hair was shown to be affected by their age and, in the case of magnesium, by the week of pregnancy.ConclusionsIt was observed that the diet of pregnant women is characterised by low levels of Fe, Zn, Ca, Mg, vitamin D, and folic acid. Dietary supplementation with vitamins and minerals significantly increases the daily Fe and folic acid intake in pregnant women. The concentration of Zn and Mg in hair depends on the age of pregnant women and Mg level in the hair of women decreases during pregnancy.

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Evaluation of Mineral Concentrations in Maternal Serum Before and After Birth and in Newborn Cord Blood Postpartum—Preliminary Study

Cited by 17 publications

References 24 publications

Evaluation of Essential and Toxic Elements in Amniotic Fluid and Maternal Serum at Birth

Evaluation of Essential and Toxic Elements in Amniotic Fluid and Maternal Serum at Birth

Serum Magnesium Levels in Preterm Infants Are Higher Than Adult Levels: A Systematic Literature Review and Meta-Analysis

Assessment of dietary intake and mineral status in pregnant women

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