Evaluation of MIh Scoring System in Diagnosis of Obstructive Sleep Apnea Syndrome

Xu, Qinxing; Du, Junwei; Ling, Xiaobo; Lu, Yangfei

doi:10.12659/msm.904087

Cited by 12 publications

(16 citation statements)

References 31 publications

(28 reference statements)

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“…These levels were significantly lower than the controls (N=30) matched for age, sex and BMI, which showed healthy levels of mean serum Mg serum at 2.19 ± 0.36 mg/dL (p<0.0001). These findings were similar to that of Xu et al [24], where patients with OSA (N=33, 1.71±0.21 mg/dL) had serum Mg levels significantly lower (p=0.021) than those in the control group (N=33, 2.19±0.36 mg/dL). Furthermore, 23 patients (69.7%) in the OSA group demonstrated hypomagnesemia.…”

Section: Comparing To Healthy Controlssupporting

confidence: 91%

“…Five articles were excluded with reasons (Figure 1). Six studies [21][22][23][24][25][26] are included in this systematic review, and five in the meta-analysis.…”

Section: Search Resultsmentioning

confidence: 99%

“…Investigation of heterogeneity by eliminating studies found heterogeneity did not reduce with the exclusion of any single study, even with the study which has apparent dissimilar sample (Jiao et al [22]). Heterogeneity only reduced to moderate (I 2 =36%) after eliminating three studies with the lowest means [21,23,24] with participants consisting of mostly hypomagnesemia OSA patients. The sizeable statistical heterogeneity across studies can be due to the inherently diverse characteristics of the OSA patient population.…”

Section: Meta-analysis -Pooled Meanmentioning

confidence: 99%

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Serum Magnesium Levels in Patients with Obstructive Sleep Apnoea: A Systematic Review and Meta-Analysis

Wadee¹,

Ooi²,

Pak³

2021

Preprint

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Purpose: Obstructive sleep apnoea (OSA) affects patients’ quality of life and health. Magnesium (Mg) is an essential mineral and a potent antioxidant. Mg deficiency can worsen oxidative stress caused by sleep deprivation or disorders. The impact of OSA on serum Mg levels and its health consequences remain unclear. Methods: This study systematically reviewed clinical studies investigating the serum Mg levels of OSA patients and the potential relationships with other biomarkers.Results: Six articles were included for qualitative synthesis; five were used in quantitative analysis. Two out of four studies that compared OSA patients to healthy controls found them to have significantly lower serum Mg levels. Our meta-analysis with three studies shows that patients with OSA had significantly lower serum Mg with an effect size of -1.22 (95% CI: -2.24, -0.21). However, the mean serum Mg level of OSA patients (n=251) pooled from five studies (1.90 mg/dL, 95% CI: 1.77, 2.04) does not differ significantly from the normal range. OSA severity appears to affect serum Mg negatively. Serum Mg levels generally improve after treatment, coincide with the improvement of OSA severity. Low serum Mg levels correlate with worsening of cardiovascular risk biomarkers of C-reactive protein, ischaemia-modified albumin, and carotid intima-media thickness. The serum Mg levels also potentially correlate with biomarkers for lipid profile, glucose metabolism, calcium and heavy metals. Conclusions: Sleep deprivation appears to deplete Mg levels of OSA patients, making them at risk of Mg deficiency, which potentially increases systemic inflammation and the risk of cardiovascular and metabolic diseases.

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Section: Comparing To Healthy Controlssupporting

confidence: 91%

“…Five articles were excluded with reasons (Figure 1). Six studies [21][22][23][24][25][26] are included in this systematic review, and five in the meta-analysis.…”

Section: Search Resultsmentioning

confidence: 99%

Section: Meta-analysis -Pooled Meanmentioning

confidence: 99%

See 1 more Smart Citation

Serum Magnesium Levels in Patients with Obstructive Sleep Apnoea: A Systematic Review and Meta-Analysis

Wadee¹,

Ooi²,

Pak³

2021

Preprint

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“…Twenty articles were excluded with reasons ( Figure 1 ). Six studies [ 21 , 22 , 23 , 24 , 25 , 26 ] are included in this systematic review and meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Serum Magnesium Levels in Patients with Obstructive Sleep Apnoea: A Systematic Review and Meta-Analysis

2022

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Aims: Obstructive sleep apnoea (OSA) affects patients’ quality of life and health. Magnesium (Mg) is an essential mineral and a potent antioxidant. Mg deficiency can worsen oxidative stress caused by sleep deprivation or disorders. The impact of OSA on serum Mg levels and its health consequences remain unclear. Data Synthesis: This study systematically reviewed clinical studies investigating the serum Mg levels of OSA patients and the potential relationships with other biomarkers. Six articles were included for qualitative synthesis and quantitative analysis. Two out of four studies that compared OSA patients to healthy controls found them to have significantly lower serum Mg levels. Our meta-analysis with three studies shows that patients with OSA had significantly lower serum Mg with an effect size of −1.22 (95% CI: −2.24, −0.21). However, the mean serum Mg level of OSA patients (n = 251) pooled from five studies (1.90 mg/dL, 95% CI: 1.77, 2.04) does not differ significantly from the normal range between 1.82 to 2.30 mg/dL. OSA severity appears to affect serum Mg negatively. Serum Mg levels generally improve after treatment, coinciding with the improvement of OSA severity. Low serum Mg levels correlate with the worsening of cardiovascular risk biomarkers of C-reactive protein, ischaemia-modified albumin, and carotid intima-media thickness. The serum Mg levels also potentially correlate with biomarkers for lipid profile, glucose metabolism, calcium, and heavy metals. Conclusions: Sleep deprivation appears to deplete Mg levels of OSA patients, making them at risk of Mg deficiency, which potentially increases systemic inflammation and the risk of cardiovascular and metabolic diseases.

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“…A study including patients with obstructive sleep apnea reported that serum amounts of IMA increased with the presence and severity of disease. [33] It was also reported that increased serum IMA levels might be regarded as a marker of increased tissue hypoxia in patients with acute leukemia. [34] In addition, in recent years, several studies have shown an interest to IMA levels and its possible correlation with diseases such as chronic obstructive pulmonary disease, acute rheumatic fever, and nasal polyposis.…”

Section: Discussionmentioning

confidence: 99%

Ischemia-modified albumin levels in patients with idiopathic sudden sensorineural hearing loss

Cırık¹

2019

Tr-ENT

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Objectives: This study aims to investigate whether serum levels of ischemia-modified albumin (IMA) are associated with idiopathic sudden sensorineural hearing loss (ISSNHL). Patients and Methods: Between December 2015 and June 2017, a total of 17 patients (9 males, 8 females; mean age 49.4±18.0 years; range, 24 to 88 years) with ISSNHL and 24 age-and sex-matched healthy individuals (12 males, 12 females; mean age 44.5±13.3 years; range, 30 to 81 years) as the control group were included in the study. All patients underwent audiometric examination at the time of admission immediately before the beginning of the treatment and weekly after treatment initiation until one month using the Interacoustics AC40 audiometer. Serum IMA levels were evaluated using blood samples from the antecubital vein of both patient and control groups. The samples were centrifuged to separate the serum from the cells. Albumin cobalt binding test was used for IMA measurement. Results: The mean IMA level was 0.374±0.081 absorbance units (ABSU) (range, 0.205 to 0.536) in the study group at the time of diagnosis, 0.358±0.051 ABSU (range, 0.297 to 0.466) in the post-treatment period, at least four weeks after onset, and 0.358±0.053 ABSU (range, 0.281 to 0.434) in the control group. There was no statistically significant difference between the patient and control groups. The IMA levels of the patients with ISSNHL in the post-treatment period were lower than the onset of illness, although this difference was not statically significant (0.440). Conclusion: Our study results demonstrated that serum IMA levels in the patients with ISSNHL did not differ from the control group.

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Evaluation of MIh Scoring System in Diagnosis of Obstructive Sleep Apnea Syndrome

Cited by 12 publications

References 31 publications

Serum Magnesium Levels in Patients with Obstructive Sleep Apnoea: A Systematic Review and Meta-Analysis

Serum Magnesium Levels in Patients with Obstructive Sleep Apnoea: A Systematic Review and Meta-Analysis

Serum Magnesium Levels in Patients with Obstructive Sleep Apnoea: A Systematic Review and Meta-Analysis

Ischemia-modified albumin levels in patients with idiopathic sudden sensorineural hearing loss

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