Evaluation of MicroRNA-210 and Protein tyrosine phosphatase, non-receptor type 2 in Pre-eclampsia

Adel, Seham; Mansour, Amal; Louka, Manal L.; Matboli, Marwa; El-Mekkawi, Sherif F; Swelam, N.

doi:10.1016/j.gene.2016.10.014

Cited by 17 publications

(9 citation statements)

References 22 publications

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“…Placental expression of miR-210 is up-regulated in pregnancies complicated with PE in comparison to normal pregnancies. This increased level of miR-210 is related to down-regulation of PTPN2 mRNA, indicating a direct role in the pathogenesis of PE disease (53).…”

Section: Hypoxic Conditionmentioning

confidence: 90%

MiRNA-210: A Current Overview

et al. 2017

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microRNAs (miRNAs) are a group of highly conserved small non-coding RNAs that were found to enhance mRNA degradation or inhibit post-transcriptional translation. Accumulating evidence indicates that miRNAs contribute to tumorigenesis and cancer metastasis. microRNA-210 has been largely studied in the past several years and has been identified as a major miRNA induced under hypoxia. A variety of miR-210 targets have been identified pointing to its role, not only in mitochondrial metabolism, but also in angiogenesis, the DNA damage response, cell proliferation, and apoptosis. Based on earlier research findings, this review aims to provide a current overview on the involvement of miRNA-210 in biological processes and diseases.

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Section: Hypoxic Conditionmentioning

confidence: 90%

MiRNA-210: A Current Overview

et al. 2017

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“…Several members of the microRNA panel that we found predictive of preeclampsia risk may have functions associated with preeclampsia’s pathogenesis. For example, miR-210 can down regulate PTPN2 mRNA contributing to the pathogenesis of preeclampsia and has a central role in the switch from trophoblast proliferation to an invasive phenotype [ 28 ]. MicroRNA-148a has been shown to downregulate HLA-G expression which may prevent inhibition of NK cell killing through the LILRB1 inhibitory receptor [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Peripheral blood cell microRNA quantification during the first trimester predicts preeclampsia: Proof of concept

Winger

Reed

et al. 2018

PLoS ONE

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ObjectiveWe investigated the capacity of microRNAs isolated from peripheral blood buffy coat collected late during the first trimester to predict preeclampsia.Study designThe cohort study comprised 48 pregnant women with the following pregnancy outcomes: 8 preeclampsia and 40 with normal delivery outcomes. Quantitative rtPCR was performed on a panel of 30 microRNAs from buffy coat samples drawn at a mean of 12.7±0.5 weeks gestation. MicroRNA Risk Scores were calculated and AUC-ROC calculations derived.ResultsThe AUC-ROC for preeclampsia risk was 0.91 (p<0.0001). When women with normal delivery and high-risk background (those with SLE/APS, chronic hypertension and/or Type 2 Diabetes) were compared to women who developed preeclampsia but with a normal risk background (without these mentioned risk factors), preeclampsia was still predicted with an AUC-ROC of 0.92 (p<0.0001).ConclusionMicroRNA quantification of peripheral immune cell microRNA provides sensitive and specific prediction of preeclampsia in the first trimester of pregnant women. With this study, we extend the range during which disorders of the placental bed may be predicted from early to the end of the first trimester. This study confirms that buffy coat may be used as a sample preparation.

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“…Other summative phthalate measures were not associated with placental miR expression, but 10 miRs were differentially associated with individual phthalates, and there were moderate associations between the expression of several miRs and the expression of selected placental genes [ 81 ]. The significance of these changes in miR expression for placental function in humans warrants future inquiry, as target genes for these miRs in the placenta are likely to be numerous and studies into the downstream functional roles of placental miRs are ongoing [ 84–87 ]. However, overall, these studies suggest that both phthalates and BPA may alter placental miRs, which likely has consequences for protein translation and the resulting downstream phenotypes.…”

Section: Epigenetic Consequences Of Bpa or Phthalate Exposures In Thementioning

confidence: 99%

Impacts of bisphenol A (BPA) and phthalate exposures on epigenetic outcomes in the human placenta

Strakovsky

Schantz

2018

Environmental Epigenetics

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The placenta guides fetal growth and development. Bisphenol A (BPA) and phthalates are widespread environmental contaminants and endocrine disruptors, and the placental epigenetic response to these chemicals is an area of growing research interest. Therefore, our objective was to summarize research linking BPA or phthalate exposure to placental outcomes in human pregnancies, with a particular focus on epigenetic endpoints. In PubMed, studies were selected for review (without limiting start date and ending on 1 May 2018) if they reported any direct effects of BPA or phthalates on the placenta in humans. Collectively, available studies suggest that BPA and phthalate exposures are associated with changes to placental micro-RNA expression, DNA methylation, and genomic imprinting. Furthermore, several studies suggest that fetal sex may be an important modifier of placental outcomes in response to these chemicals. Studies in humans demonstrate associations of BPA and phthalate exposure with adverse placental outcomes. Moving forward, more studies should consider sex differences (termed “placental sex”) in the measured outcomes, and should utilize appropriate statistical approaches to assess modification by fetal sex. Furthermore, more consistent sample collection and molecular outcome assessment paradigms will be indispensable for making progress in the field. These advances, together with improved non-invasive tools for measuring placental function and outcomes across pregnancy, will be critical for understanding the mechanisms driving placental epigenetic disruption in response to BPA and phthalates, and how these disruptions translate into placental and fetal health.

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Evaluation of MicroRNA-210 and Protein tyrosine phosphatase, non-receptor type 2 in Pre-eclampsia

Cited by 17 publications

References 22 publications

MiRNA-210: A Current Overview

MiRNA-210: A Current Overview

Peripheral blood cell microRNA quantification during the first trimester predicts preeclampsia: Proof of concept

Impacts of bisphenol A (BPA) and phthalate exposures on epigenetic outcomes in the human placenta

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