Evaluation of Microorganisms and Antibiotic Resistance Profile Isolated in Intensive Care Unit Patients

Çetin, Şerife; Çelik, İ̇lhami; Artan, Cem

doi:10.4274/tybd.galenos.2019.55477

Cited by 6 publications

(3 citation statements)

References 4 publications

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“…As the duration of ICU stay increases, the risk of infection increases and, in turn, infection significantly increases the duration of hospital stay (11 -16). In a study by Aygen et al, the risk of HAIs increased as the duration of hospital stay in nosocomial infections increased (5) (21). In the present study, the pathogens that grew in the samples from the lower respiratory tract were Acinetobacter spp.…”

Section: Discussionsupporting

confidence: 47%

Solunumsal Yoğun Bakım Ünitesinde İzole Edilen Mikroorganizmalar ve Antibiyotik Direnç Durumlarının Yıllara Göre Değişimi ve Mortaliteye Etkisi

TURAN,

SEZGİ,

ABAKAY

et al. 2023

Harran Üniversitesi Tıp Fakültesi Dergisi

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BACKGROUND: Intensive care units (ICU) are multidisciplinary departments where patients with life-threatening diseases, major surgical interventions, respiratory failure, coma condition, hemodynamic insufficiency, and ≥1 organ failure are admitted for relevant diagnoses and treatment. AIM: The present study sought to investigate pathogens causing infections in patients admitted to our respiratory ICU and their antibiotic resistance patterns. MATERİALS and METHOD: The antibiogram results and clinical data of all patient samples submitted between January 1, 2008, and December 31, 2010, were retrospectively reviewed. RESULT: In total, 248 patients with 561 culture results were included in the study. Microbial growth was detected in the following samples: blood, 336 (59.9%); deep tracheal aspirate, 104 (18.6%); urine, 89 (15.9%); wound drain, 12 (2.1%); central venous catheter liquid, 7 (1.3%); phlegm, 10 (1.8%); Foley tip liquid, 1 (0.2%); and pleural effusion, and 1 (0.2%). Rapid growth was most frequently noted in the cultures of coagulase-negative staphylococci (25.3%), Acinetobacter spp. (23.1%), and Escherichia coli (12.6%). STATISTICAL ANALYSIS Descriptive statistics for continuous variables were expressed as means and standard deviations. The intermittent variables were converted into cross-tables and analyzed using Fisher’s exact and Pearson’s chi-square tests. The normal distribution of the study data was assessed using Kolmogorov–Smirnov test. The mean values of the variables were analyzed using Student’s t-test. Bidirectional hypotheses were used, and a p-value of <0.05 was considered statistically significant. The IBM Statistical Package for the Social Sciences Ver. 18.0 for Windows (SPSS Inc., Chicago, IL, USA) software was used for statistical analyses. IN CONCLUSION, the present study revealed microorganisms’ resistance profiles similar to those of other relevant studies. The study provides important insights into the selection of empiric antibiotic therapy for patients admitted in intensive care unit. Keywords: respiratory intensive care unit, intensive care infections, antibiotic resistance, antibiotic susceptibility

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Section: Discussionsupporting

confidence: 47%

Solunumsal Yoğun Bakım Ünitesinde İzole Edilen Mikroorganizmalar ve Antibiyotik Direnç Durumlarının Yıllara Göre Değişimi ve Mortaliteye Etkisi

TURAN,

SEZGİ,

ABAKAY

et al. 2023

Harran Üniversitesi Tıp Fakültesi Dergisi

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“…In studies conducted in our country, HAI density varies between 15.4 and 44.7 (10). Cetin et al (11) found the HAI density of 21.9 in their two-year analysis of patients hospitalized in the ICU. In our study, we found the HAI density as 17.45.…”

Section: Discussionmentioning

confidence: 96%

“…HAI rates with Gram-negative bacteria, which do not cause infection in healthy individuals but are frequently encountered in ICUs, have increased in recent years (3,8,9,11) (10). In a multicenter study, culture results were examined, and Gram (-) microorganisms were detected with 70.7% (Klebsiella spp., E. coli, Pseudomonas and Acinetobacter, respectively).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of hospital acquired infections in the tertiary intensive care unit: a three-year analysis

Aydin

Aydın

2022

Journal of Health Sciences and Medicine

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Introduction: Hospital-acquired infections (HAI) occurring in intensive care units (ICUs) are an important risk factor for mortality and morbidity. In some patient groups followed in ICUs, the risk of developing nosocomial infections increases even more. Especially, patients with end-stage renal disease (ESRD) carry a serious risk for HAI when they are hospitalized in ICUs. Our aim is to determine the rate and incidence of hospital infection, the distribution of infections and the most common microorganisms in our ICU, to initiate appropriate empirical treatment and to prevent the development of antibiotic resistance. Material and Method: A total 158 patients with a diagnosis of hospital-acquired infection hospitalized between January 2017 and December 2019 at general internal medicine intensive care unit, were included in this study. The clinical findings, culture results and laboratory data of the patients were recorded. According to years, the HAI rate, density and infection agents in the ICU were determined. Results: 158 episodes of nosocomial infections were detected in 128 of 556 patients who were hospitalized within three years. The hospitalization day was 9048, and the three-year ICU HAI rate was calculated as 29.19%. HAI density was 17.45 in 1000 patient days. Bloodstream infection was the most common (30.38%), followed by ventilator-associated pneumonia (28.48%) and catheter-related urinary tract infection (24.68%). Gram-negative microorganisms were the most common infectious agents. Among the Gram-negative bacteria, the most frequently isolated bacteria were A. baumannii, K. pneumoniae and P. aeruginosa. Among Gram-positive bacteria, Enterococcus spp. was most frequently isolated Conclusion: The risk of HAI is high in patients hospitalized in ICUs. In order to control nosocomial infections, HAI incidences and rates should be evaluated, infectious agents, and prospective effective infection control strategies should be developed by taking necessary precautions according to surveillance results. These measures will significantly reduce the incidence of HAI.

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External Quality Assessment of SARS-CoV-2 Sequencing: an ESGMD-SSM Pilot Trial across 15 European Laboratories

et al. 2022

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Objective: This first pilot on external quality assessment (EQA) of SARS-CoV-2 whole genome sequencing, initiated by the ESCMID Study Group for Genomic and Molecular Diagnostics (ESGMD) and Swiss Society for Microbiology (SSM), aims to build a framework between laboratories in order to improve pathogen surveillance sequencing. Methods: Ten samples with varying viral loads were sent out to 15 clinical laboratories who had free choice of sequencing methods and bioinformatic analyses. The key aspects on which the individual centres were compared on were identification of 1) SNPs and indels, 2) Pango lineages, and 3) clusters between samples. Results: The participating laboratories used a wide array of methods and analysis pipelines. Most were able to generate whole genomes for all samples. Genomes were sequenced to varying depth (up to 100-fold difference across centres). There was a very good consensus regarding the majority of reporting criteria, but there were a few discrepancies in lineage and cluster assignment. Additionally, there were inconsistencies in variant calling. The main reasons for discrepancies were missing data, bioinformatic choices, and interpretation of data. Conclusions: The pilot EQA was an overall success. It was able to show the high quality of participating labs and provide valuable feedback in cases where problems occurred, thereby improving the sequencing setup of laboratories. A larger follow-up EQA should, however, improve on defining the variables and format of the report. Additionally, contamination and/or minority variants should be a further aspect of assessment.

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Evaluation of Microorganisms and Antibiotic Resistance Profile Isolated in Intensive Care Unit Patients

Cited by 6 publications

References 4 publications

Solunumsal Yoğun Bakım Ünitesinde İzole Edilen Mikroorganizmalar ve Antibiyotik Direnç Durumlarının Yıllara Göre Değişimi ve Mortaliteye Etkisi

Solunumsal Yoğun Bakım Ünitesinde İzole Edilen Mikroorganizmalar ve Antibiyotik Direnç Durumlarının Yıllara Göre Değişimi ve Mortaliteye Etkisi

Evaluation of hospital acquired infections in the tertiary intensive care unit: a three-year analysis

External Quality Assessment of SARS-CoV-2 Sequencing: an ESGMD-SSM Pilot Trial across 15 European Laboratories

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