Evaluation of methyl chavicol concentration by different evaporation processes using central composite experimental design

Evaluation of lactic acid purification from fermentation broth by hybrid short path evaporation using factorial experimental design

“…Coded variables Real variables Residue Distillate evaporator temperature and feed flow rate were the ones that had greatest effect on the response variable in the short path evaporation process [18,19]. The results obtained in this work confirm this.…”

“…, where X i is the dimensionless coded value of the ith factor, n i is the real value of the ith factor, n 0 is the real value of the ith factor at the central point, and Dn i is the step change value of the real variable i [19].…”

“…Hybrid short path evaporation [17][18][19] is an alternative separation process with potential for the recovery and concentration of thermally unstable molecules such as lactic acid. It has been recognized as a promising technology mainly because of its low evaporation temperature and short residence time, which minimize problems with thermal decomposition [20].…”

“…It allows the determination and evaluation of the relative significance of operational parameters on the process, even in the presence of complex interactions [19]. In the studied process higher operating pressure (1000 Pa), compared to that usually employed in conventional molecular distillation, and one step of refining were used, which make this technique more suitable for lactic acid purification than the literature published works.…”

Unit Operation Optimization for the Manufacturing of Botanical Injections Using a Design Space Approach: A Case Study of Water Precipitation

“…Plackett–Burman design or fractional factorial design are usually applied to select CPPs [16] . In order to obtain design space, response surface methodology, such as central composite design [17] or Box-Behnken design [18] , is widely applied. Recently, Rozet et al suggested that design space is “a multivariate domain of input factors ensuring that critically chosen responses are included within predefined limits with an acceptable level of probability” [16] .…”