Evaluation of Methods Used in the Prediction of Hypertensive Disorders of Pregnancy

Conde-Agudelo, Agustín; Lede, Roberto; Belizán, José M.

doi:10.1097/00006254-199403000-00027

Cited by 66 publications

(21 citation statements)

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“…Sanchez-Ramos et al (22) found a relative risk of 9.4 of predicting preeclampsia when the patient shows urinary calcium excretion lower than 195 mg/24 h. Baker and Hackett (23) did not find significantly predictive values in the measurement of the albumin/creatinine and/or calcium/creatinine ratio in relation to the diagnosis of preeclampsia. Conde-Agudelo et al (24) established that urinary calcium excretion produces contradictory and inconclusive findings for the predictive diagnosis of preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Calciuria and preeclampsia

Ramos¹,

Costa²,

Kessler³

et al. 1998

Braz J Med Biol Res

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Urinary calcium excretion has been reported to be diminished in preeclampsia. The objective of the present study was to determine urinary calcium excretion in pregnant patients with chronic arterial hypertension (CAH) and preeclampsia (PE), and in normotensive patients (N). Forty-four pregnant patients (gestational age, 20-42 weeks; 18 CAH, 17 PE, 9 N) were evaluated for calciuria, proteinuria, plasma uric acid and blood pressure. Patients with PE (82 ± 15.1 mg/ 24 h) showed significantly lower calciuria (P<0.05) than the group with CAH (147 ± 24.9 mg/24 h) and the N group (317 ± 86.0 mg/24 h) (P<0.05, Student t-test). Plasma uric acid was significantly higher in the PE group (6.1 ± 0.38 mg/dl) than the CAH group (5.0 ± 0.33 mg/ dl; P<0.05), which also presented higher proteinuria levels, although the difference was not statistically significant. Diastolic and systolic blood pressure did not differ between the PE (164 ± 105 mmHg) and CAH (164 ± 107 mmHg) groups. Calciuria was significantly lower in the group with preeclampsia than in the group with chronic arterial hypertension. We conclude that calciuria can be a further factor for identifying preeclampsia.

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Section: Discussionmentioning

confidence: 99%

Calciuria and preeclampsia

Ramos¹,

Costa²,

Kessler³

et al. 1998

Braz J Med Biol Res

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“…[6][7][8][9][10][11][12][13][14] In a recent systematic review on the subject, a raised serum uric acid was associated with an almost doubled risk of severe complications, such as eclampsia, severe hypertension, and perinatal death. 15 The present is intended to study uric acid as an important biomarker in hypertension in pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Uric acid as an important biomarker in hypertensive disorders in pregnancy

Kondareddy

Prathap

2016

Int J Reprod Contracept Obstet Gynecol

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Background: Hypertension in pregnancy is a global problem and complicates approximately 10-17% of pregnancies. The incidence of PIH in India ranges from 5% to 15%. Uric acid is a marker of oxidative stress, tissue injury and renal dysfunction and therefore might be helpful in the prediction of complications of PE. Literature on serum uric acid as a predictor of complications of PE is conflicting. The present is intended to study uric acid as an important biomarker in hypertension in pregnancy. Methods: This was prospective observational analytical case control study of 180 individuals done at JSS Hospital, Mysore, India from January 2015 to July 2016. Results: A positive correlation was observed between rise in uric acid and severity of hypertension in pregnancy (p <0.01). Hypertensive mothers with uric acid levels >6.0mg/dl shows 100% maternal deaths, 79.4% with eclampsia and 71.9% with preterm delivery. Conclusions: A positive correlation was observed between rise in uric acid and severity of hypertension in pregnancy. Hyperuricemia in patients with hypertensive disorders of pregnancy is a strong risk factor for several maternal and perinatal complications.

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“…Our findings suggest that maternal cardiovascular background mechanisms in the etiology of preeclampsia may differ between singleton and twin pregnancies. In this study, however, there were no measurable differences in maternal systolic and diastolic blood pressure, pulse rate or blood viscosity (hematocrit), which have been re-ported to indicate the development of preeclampsia [20] and to affect the variability of the (renal) Doppler parameters [5-7, 21, 22] between the singleton and twin pregnancies. Thus, the prolonged acceleration time may indicate the relative stenosis of the renal main arteries for the increased plasma flow in women with nonpreeclamptic twin pregnancy.…”

Section: Changes In Acceleration Time and Systolic Accelerationmentioning

confidence: 58%

Hemodynamic Changes in Maternal Renal Arteries in Twin Pregnancy

Igarashi

Suzuki²

2009

Gynecol Obstet Invest

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Aim: We examined whether the Doppler waveforms of the maternal renal main arteries are altered in women with twin pregnancy compared with those in singleton pregnancy. Methods: The indices of vascular resistance and acceleration time of the maternal main renal arteries were obtained from 19 healthy women at 37–38 weeks of singleton gestation and 17 women at the same gestational age with nonpreeclamptic twin gestation. Results: There were no significant differences in the indices of vascular resistance between the singleton and twin groups. However, the acceleration time was significantly prolonged in the twin pregnancy group compared with that in the singleton pregnancy group (83.7 ± 24 vs. 59.8 ± 12 ms, p < 0.01). Conclusion: The current results imply that maternal renal arteries are more significantly affected by hemodynamic changes in twin pregnancy than in singleton pregnancy.

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Evaluation of Methods Used in the Prediction of Hypertensive Disorders of Pregnancy

Cited by 66 publications

References 0 publications

Calciuria and preeclampsia

Calciuria and preeclampsia

Uric acid as an important biomarker in hypertensive disorders in pregnancy

Hemodynamic Changes in Maternal Renal Arteries in Twin Pregnancy

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