Evaluation of methionine and tryptophan derivatised vehicles: Met-ac-TE3A/Trp-ac-TE3A for tumor imaging

Abstract

Two novel amino acid (methionine and tryptophan) appended 1,4,8,11-tetraazacyclotetradecane triacetate (TE3A) compounds Met-ac-TE3A and Trp-ac-TE3A were synthesized and evaluated for imaging applications.

Comparative evaluation of Bis(thiosemicarbazone)- Biotin and Met-ac-TE3A for tumor imaging

“…In continuation of our work for design of novel agents having these vehicles, we previously synthesized DTPA-bis(methionine) [14] and DO3A-ActMet [15] and evaluated for imaging applications. Recently we have evaluated two novel amino acids (methionine and tryptophan) appended 1,4,8,11-tetraazacyclotetradecane triacetate (TE3A) compounds Met-ac-TE3A and Trp-ac-TE3A for tumor imaging in which Met-ac-TE3A showed very promising results for further evaluations [16].…”