Evaluation of metal nanoparticles for drug delivery systems

Adeyemi, Oluyomi Stephen; Sulaiman, Faoziyat Adenike

doi:10.7555/jbr.28.20130096

Cited by 77 publications

(25 citation statements)

References 16 publications

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“…In toxoplasmosis, silver, platinum, and gold nanoparticles were shown to be attractive drug carriers because of their antimicrobial and antiparasitic effects. They were described to accumulate in specific tissues and to act on the replication stages of T. gondii through interactions with reactive oxygen species (ROS) [25]. The tendency of nanoparticles to accumulate in specific tissues supports the idea of using nanoparticles to target parasite cysts in the host tissue.…”

Section: Discussionmentioning

confidence: 97%

Isolation of Human Small Extracellular Vesicles and Tracking of Their Uptake by Retinal Pigment Epithelial Cells In Vitro

Eberhard

Yerly

et al. 2020

IJMS

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Small extracellular vesicles (EVs) are among the most frequently investigated EVs and play major roles in intercellular communication by delivering various cargo molecules to target cells. They could potentially represent an alternative delivery strategy to treat ocular toxoplasmosis, a parasitosis affecting the retinal pigment epithelium (RPE). To date, the uptake of human small EVs by RPE cells has never been reported. In this study, we report on the intracellular uptake of fluorescently labelled human urine and fibroblast-derived small EVs by human RPE cells. In summary, both dye-labelled urinary small EVs and small EVs obtained from fibroblasts stably expressing membrane-bound green fluorescent protein were successfully internalized by RPE cells as revealed by immunohistochemistry. In recipient ARPE19 cells, BODIPY-labelled small EVs were found in close vicinity to the parasite Toxoplasma gondii. Additionally, an ultrastructural method was enabled to distinguish between labelled exogenous and endogenous small EVs within target cells.

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Section: Discussionmentioning

confidence: 97%

Isolation of Human Small Extracellular Vesicles and Tracking of Their Uptake by Retinal Pigment Epithelial Cells In Vitro

Eberhard

Yerly

et al. 2020

IJMS

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“…The main reaction of this technique is oxidation or reduction using biomolecules [1]. The metal nanoparticles with a definite shape, size, and crystal nature have a considerable application in medicine including cancer therapy [2], DNA analysis [3], drug delivery [4], biosensor [5] and magnetic resonance imaging [6], apart from agricultural [7], environmental remediation [8], pharmaceutical [9], electronics and commercial industries [10]. Currently, the development of biocompatible nanoparticles is of great concern among the scientists worldwide, because of their unique physical, chemical and biological characteristics [11].…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis and Characterization, Antioxidant and Antimicrobial Activities of Selenium Nanoparticles from Ethanol Extract of Bee Propolis

Shubharani¹,

Mahadevaiah²,

V.N.Yogan³

et al. 2019

J Nanomed Nanotechnol

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Aim: Biosynthesis of selenium nanoparticles (SeNPs) has gained significant interest due to their distinctive chemical and biological properties that is essential for potential application in various fields. Methods:In the present study, propolis, the beehive product collected from 5 different Indian states like Haryana, Himachal Pradesh, Uttaranchal, Karnataka and Kerala were used for the biosynthesis of SeNPs and characterized by using UV-vis spectrophotometer, fourier transform spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscopy (SEM).Results: SeNPs biosynthesized by propolis were observed as crystalline, oval shaped and smooth surface particles. Study also reports the efficiency of 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), 2,2-diphenyl-1picrylhydrazyl (DPPH), Fluorescence recovery after photobleaching (FRAP) and superoxide dismutase (SOD) assay to estimate the antioxidant potential. The antimicrobial assay was evaluated only for SeNPs synthesized from propolis extracts obtained from Karnataka state showed high antioxidant activity. The antibacterial activity against pathogenic gram-positive bacterial strains (Staphylococcus aureus, Bacillus cereus and Streptococcus mutans), gram-negative bacterial strains (Escherichia coli, Salmonella typhi and Pseudomonas aeruginosa) was evaluated by resazurin microtiter plate method to check the minimum inhibition concentration (MIC). The antifungal activity of pathogenic fungi such as Aspergillus niger, Aspergillus flavon and Candida albicans were determined by well diffusion method. Conclusion:It is the first report describing the biosynthesis of selenium nanoparticles using bee propolis. This study demonstrated the antioxidant and antimicrobial potential of SeNPs biosynthesised by using ethanol extract of propolis.

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“…Metal nanoparticles exhibit distinct physiochemical properties from their bulk counterparts. This phenomenon manifests itself in numerous applications such as chemical and biological sensing [1], targeted drug delivery [2], and heterogeneous catalysis [3]. Understanding effects of particle size, shape, and composition on the binding affinity of molecules to surface metal atoms is of key importance for rational design of functional materials with the utmost efficiency and durability.…”

mentioning

confidence: 99%

Orbitalwise Coordination Number for Predicting Adsorption Properties of Metal Nanocatalysts

2017

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We present the orbitalwise coordination number CN^{α} (α=s or d) as a reactivity descriptor for metal nanocatalysts. With the noble metal Au (5d^{10}6s^{1}) as a specific case, the CN^{s} computed using the two-center s-electron hopping integrals to neighboring atoms provides an accurate and robust description of the trends in CO and O adsorption energies on extended surfaces terminated with different facets and nanoparticles of varying size and shape, outperforming existing bond-counting methods. Importantly, the CN^{s} has a solid physiochemical basis via a direct connection to the moment characteristics of the projected density of states onto the s orbital of a Au adsorption site. Furthermore, the CN^{s} shows promise as a viable descriptor for predicting adsorption properties of Au alloy nanoparticles with size-dependent lattice strains and coinage metal ligands.

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Evaluation of metal nanoparticles for drug delivery systems

Cited by 77 publications

References 16 publications

Isolation of Human Small Extracellular Vesicles and Tracking of Their Uptake by Retinal Pigment Epithelial Cells In Vitro

Isolation of Human Small Extracellular Vesicles and Tracking of Their Uptake by Retinal Pigment Epithelial Cells In Vitro

Biosynthesis and Characterization, Antioxidant and Antimicrobial Activities of Selenium Nanoparticles from Ethanol Extract of Bee Propolis

Orbitalwise Coordination Number for Predicting Adsorption Properties of Metal Nanocatalysts

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