Evaluation of Mesoporous TCPSi, MCM-41, SBA-15, and TUD-1 Materials as API Carriers for Oral Drug Delivery

Heikkilä, Teemu; Salonen, Jarno; Tuura, Jaani; Kumar, Narendra; Salmi, Tapio; Murzin, Dmitry Yu.; Hamdy, Mohamed S.; Mul, Guido; La, Laitinen; Kaukonen, Ann Marie; Hirvonen, Jouni; Lehto, Vesa‐Pekka

doi:10.1080/10717540601098823

Cited by 169 publications

(88 citation statements)

References 28 publications

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“…was shown to enhance piroxicam's dissolution rate considerably and attained a rapid analgesic onset that was comparable to the analgesic effect of the marketed product Brexin ® (120). Also, the use of MS as a carrier for ibuprofen was found to improve the drugs dissolution rate at low pH conditions (122).…”

Section: Ms Based Materials In Drug Deliverymentioning

confidence: 90%

“…The oral delivery of ibuprofen loaded into MS materials (SBA-15, MCM-41, and TUD-1) has shown to reduce the dependency of drug dissolution profile on the pH of the in vitro assessment medium. Thus at acidic pH, ibuprofen release demonstrated a significant improvement when using mesoporous silica, which in turn enhanced the drugs bioavailability (122). Furthermore, MSN has been developed as an oral drug delivery system, where the oral absorption of telmisartan was improved significantly via greater permeability and a reduction in drug efflux (131).…”

Section: Ms Have Been Extensively Utilised As Msn (107) Ms-microsphementioning

confidence: 99%

“…The dissolution improvement associated with the utilisation of MS can be established by changing the solid state property of the entrapped drug from the crystalline to amorphous form. This in turn increases drug absorption from the intestine and consequently results in enhanced bioavailability (122). For instance, the inclusion of the hydrophobic drug 'Itraconazole' into ordered MS accelerated its release and significantly enhanced its systemic bioavailability (97,130).…”

Section: Ms Have Been Extensively Utilised As Msn (107) Ms-microsphementioning

confidence: 99%

“…MSs were used to enhance the dissolution properties of anti-inflammatory drugs (120,122), to provide controlled release (118,123) and to target their release at the preferred site of action (141). For instance, the entrapment of piroxicam (a poor water soluble drug) (~%14) into MCM-41 mesoporous silicate (characterised by a large surface area and the presence of pores with diameters larger than the piroxicam molecular size.…”

Section: Ms Based Materials In Drug Deliverymentioning

confidence: 99%

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Porous Inorganic Drug Delivery Systems—a Review

et al. 2017

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Innovative methods and materials have been developed to overcome limitations associated with current drug delivery systems. Significant developments have led to the use of a variety of materials (as excipients) such as inorganic and metallic structures; marking a transition from conventional polymers. Inorganic materials, especially those possessing significant porosity, are emerging as good candidates for the delivery of a range of drugs (anti-biotics, anti-cancer and anti-inflammatories), providing several advantages in formulation and engineering (encapsulation of drug in amorphous form, controlled delivery and improved targeting). This review focuses on key selected developments in porous drug delivery systems. The review provides a short broad overview of porous polymeric materials for drug delivery before focusing on porous inorganic materials (e.g. Santa Barbara Amorphous (SBA) and Mobil Composition of Matter (MCM)) and their utilisation in drug dosage form development. Methods for their preparation and drug loading thereafter are detailed. Several examples of porous inorganic materials, drugs used and outcomes are discussed providing the reader with an understanding of advances in the field and realistic opportunities.

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Section: Ms Based Materials In Drug Deliverymentioning

confidence: 90%

Section: Ms Have Been Extensively Utilised As Msn (107) Ms-microsphementioning

confidence: 99%

Section: Ms Have Been Extensively Utilised As Msn (107) Ms-microsphementioning

confidence: 99%

Section: Ms Based Materials In Drug Deliverymentioning

confidence: 99%

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Porous Inorganic Drug Delivery Systems—a Review

et al. 2017

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“…Nevertheless, to obtain the total amount of drug adsorbed in a SMM it is necessary to use indirect methods like thermogravimetry, porosimetry and other methods of chemical analysis [140][141][142][143][144][145][146].…”

Section: Host Drug Modelsmentioning

confidence: 99%

Drug release from ordered mesoporous silicas

Doadrio¹,

Salinas²,

Sánchez-Montero³

et al. 2015

CPD

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The state of the art in the investigation of drugs release from Silica-based ordered Mesoporous Materials (SMMs) is reviewed. First, the SMM systems used like host matrixes are described. Then, the model drugs studied until now, including their pharmacological action, structure and the mesoporous matrix employed for each drug, are comprehensively listed. Next, the factors influencing the release of drugs from SMMs and the strategies used to control the drug delivery, specially the chemical functionalization of the silica surface, are discussed. In addition, how all these factors were gathered in a kinetic equation that describes the drug release from the mesoporous matrixes is explained. The new application of molecular modeling and docking in the investigation of the drug delivery mechanisms from SMMs is also presented. Finally, the new approaches under investigation in this field are mentioned including the design of smart stimuli-responsive materials and other recent proposals for a future investigation.. 3

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