Evaluation of medicated feeds with antiparasitical and immune-enhanced Chinese herbal medicines against Ichthyophthirius multifiliis in grass carp (Ctenopharyngodon idellus)

Lin, De-Jie; Hua, Yanan; Zhang, Qizhong; Xu, De‐Hai; Fu, Yao-Wu; Liu, Yanmeng; Zhou, Sheng-Yu

doi:10.1007/s00436-016-5000-y

Cited by 19 publications

(13 citation statements)

References 52 publications

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“…A concentration of 8 mg/L for Z. officinale was 100 % effective against theronts and a concentration of 4 mg/L of C. atratum was sufficient to kill encysted tomonts. Applying the extract to the feed had a limited effect [109]. Another study showed that cynatratoside-C isolated from C. atratum showed 100 % mortality against I. multifiliis theronts from grass carp in approximately three hours at a low concentration of 0.25 mg/L.…”

Section: Plant Extractsmentioning

confidence: 99%

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The fish parasite Ichthyophthirius multifiliis – Host immunology, vaccines and novel treatments

Jørgensen

2017

Fish & Shellfish Immunology

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Ichthyophthirius multifiliis, the causative agent of white spot disease (ichthyophthiriasis) is a major burden for fish farmers and aquarists globally. The parasite infects the skin and the gills of freshwater fish, which may acquire a protective adaptive immune response against this disease, making vaccine strategies feasible. However, there is no prophylactic treatment available and repetitive treatments with auxiliary substances are needed to control the infection. Historically, a variety of drugs and chemicals have been used to combat the disease but due to changing regulations and recognition of carcinogenic and environmentally damaging effects the most efficient compounds are prohibited. A continuous search for novel substances, which are highly effective against the parasites and harmless for the fish is ongoing. These compounds should be environmentally friendly and cost-effective. This review presents recent progress within host immunology, vaccinology and a description of novel substances, which have been tested as treatments against ichthyophthiriasis.

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Section: Plant Extractsmentioning

confidence: 99%

“…Zingiber officinale Ethanol extract Grass carp -4 % (feed, days) 0/0 51.6 (significant) [109] Cynanchum atratum Ethanol extract Grass carp -4 % (feed, 10 days) 0/0 76.5 (significant) [109] Cynatratoside Contr. = control 495…”

Section: Biological Control Strategiesmentioning

confidence: 99%

The fish parasite Ichthyophthirius multifiliis – Host immunology, vaccines and novel treatments

Jørgensen

2017

Fish & Shellfish Immunology

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“…In comparison, it took 4 h to kill all theronts using commercially available copper naphthenate at a concentration of 8 mg/L (organic copper content = 2.4%) [ 27 ]. The concentrations of ethanol extracts of Zingiber officinale and Cynanchum atratum needed to achieve 100% theronts mortality were 8 mg/L and 16.0 mg/L, respectively [ 28 ]. The concentration of berberine needed to achieve 100% theront mortality at the 4 h time point was much lower than that of garlic extract, which required 62.5 mg/L for 15 h [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Assessment of Berberine against Ichthyophthirius multifiliis in Goldfish

Huang

Wang

et al. 2022

Pathogens

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Ichthyophthirius multifiliis is a pathogenic ciliate parasite, which infects almost all freshwater teleost fish and leads to significant economic losses. The present study aimed to evaluate the acute toxicity of berberine to the free-living stages of I. multifiliis, that is, theronts and tomonts. Our results indicated that 99.30% of I. multifiliis theronts were killed by a concentration of 15 mg/L berberine during the 4 h exposure time, while berberine had no effect on protomonts. Nevertheless, berberine at a concentration of 5 mg/L could effectively reduce the release of theronts from tomonts treated for 4 h. Additionally, according to the transmission electron microscopy results, berberine at 15 mg/L could strongly change the shape of protomonts, destroy their organelles, and significantly decrease the number of ribosomes. The median lethal concentration (LC50) of berberine for goldfish at 96 h was 528.44 mg/L, which was almost 67 times the median effective concentration (EC50) of berberine for killing theronts (7.86 mg/L). The results demonstrated that berberine could be an effective and safe potential parasiticide for killing I. multifiliis.

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“…These oxidizing agents are being applied in increasing amounts, but the search for alternative products is still ongoing. Herbal extracts have exhibited strong effects on different stages of the parasite (Lin et al , 2016; Mathiessen et al , 2021a), but before licensing, marketing and possible application at farm level, further investigations into the environmental impact, toxicity towards the host and any effect on human health are needed. Correspondingly, a lipopeptide (surfactant) isolated from the bacterium Pseudomonas H6 has lethal effects on the theronts, tomonts and tomocysts of Ichthyophthirius (Al-Jubury et al , 2018; Li et al , 2022).…”

Section: Parasites In Aquaculturementioning

confidence: 99%

A century of parasitology in fisheries and aquaculture

Timi

Buchmann

2023

J. Helminthol.

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Fish parasitological research associated with fisheries and aquaculture has expanded remarkably over the past century. The application of parasites as biological tags has been one of the fields in which fish parasitology has generated new insight into fish migration and stock assessments worldwide. It is a well-established discipline whose methodological issues are regularly reviewed and updated. Therefore, no concepts or case-studies will be repeated here; instead, we summarize some of the main recent findings and achievements of this methodology. These include the extension of its use in hosts other than bony fishes; the improvements in the selection of parasite tags; the recognition of the host traits affecting the use of parasite tags; and the increasingly recognized need for integrative, multidisciplinary studies combining parasites with classical methods and modern techniques, such as otolith microchemistry and genetics. Archaeological evidence points to the existence of parasitic problems associated with aquaculture activities more than a thousand years ago. However, the main surge of research within aquaculture parasitology occurred with the impressive development of aquaculture over the past century. Protozoan and metazoan parasites, causing disease in domesticated fish in confined environments, have attracted the interest of parasitologists and, due to their economic importance, funding was made available for basic and applied research. This has resulted in a profusion of basic knowledge about parasite biology, physiology, parasite–host interactions, life cycles and biochemistry. Due to the need for effective control methods, various solutions targeting host–parasite interactions (immune responses and host finding), genetics and pharmacological aspects have been in focus.

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Evaluation of medicated feeds with antiparasitical and immune-enhanced Chinese herbal medicines against Ichthyophthirius multifiliis in grass carp (Ctenopharyngodon idellus)

Cited by 19 publications

References 52 publications

The fish parasite Ichthyophthirius multifiliis – Host immunology, vaccines and novel treatments

The fish parasite Ichthyophthirius multifiliis – Host immunology, vaccines and novel treatments

In Vitro Assessment of Berberine against Ichthyophthirius multifiliis in Goldfish

A century of parasitology in fisheries and aquaculture

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