Evaluation of mechanical strength and bone regeneration ability of 3D printed kagome-structure scaffold using rabbit calvarial defect model

Lee, Se Hwan; Lee, Kang Gon; Hwang, Jai Hyun; Cho, Young‐Sam; Lee, Kang Sik; Jeong, Hun Jin; Park, Sang Hyug; Park, Yongdoo; Lee, Bu Kyu

doi:10.1016/j.msec.2019.01.050

Cited by 56 publications

(27 citation statements)

References 40 publications

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“…This regeneration time course (a logarithmic curve) has already been described in the same rat model with a beta-TCP (Chou et al, 2014) and with nanogel-crosslinked materials (Charoenlarp et al, 2018), although the investigators did not test cell-seeded scaffolds. In contrast, other studies have shown that bone reconstruction is linear (with a mean bone volume fraction of only 20% at 8 weeks) when 3D-printed PCL scaffolds were implanted in calvarial defects (Lee et al, 2019;Pae et al, 2019). The disparities between our present results and the literature data might be due to differences in the materials' composition and/or architecture.…”

Section: Discussioncontrasting

confidence: 99%

The combination of a poly‐caprolactone/nano‐hydroxyapatite honeycomb scaffold and mesenchymal stem cells promotes bone regeneration in rat calvarial defects

Naudot

Garcia

Jankovsky

et al. 2020

J Tissue Eng Regen Med

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Section: Discussioncontrasting

confidence: 99%

The combination of a poly‐caprolactone/nano‐hydroxyapatite honeycomb scaffold and mesenchymal stem cells promotes bone regeneration in rat calvarial defects

Naudot

Garcia

Jankovsky

et al. 2020

J Tissue Eng Regen Med

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“…On the other hand, OPN is reported to have multiple functions in bone regeneration, of which the presence of OPN strongly leads to enhanced cell adhesion, signaling, and mineralization. In addition, OPN is known to integrate existing bones with newly regenerated bone tissues [ 45 ]. Together with OC, these results showed that GR could enhance bone regeneration [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

3D-Printed Ginsenoside Rb1-Loaded Mesoporous Calcium Silicate/Calcium Sulfate Scaffolds for Inflammation Inhibition and Bone Regeneration

et al. 2021

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Bone defects are commonly found in the elderly and athletic population due to systemic diseases such as osteoporosis and trauma. Bone scaffolds have since been developed to enhance bone regeneration by acting as a biological extracellular scaffold for cells. The main advantage of a bone scaffold lies in its ability to provide various degrees of structural support and growth factors for cellular activities. Therefore, we designed a 3D porous scaffold that can not only provide sufficient mechanical properties but also carry drugs and promote cell viability. Ginsenoside Rb1 (GR) is an extract from panax ginseng, which has been used for bone regeneration and repair since ancient Chinese history. In this study, we fabricated scaffolds using various concentrations of GR with mesoporous calcium silicate/calcium sulfate (MSCS) and investigated the scaffold’s physical and chemical characteristic properties. PrestoBlue, F-actin staining, and ELISA were used to demonstrate the effect of the GR-contained MSCS scaffold on cell proliferation, morphology, and expression of the specific osteogenic-related protein of human dental pulp stem cells (hDPSCs). According to our data, hDPSCs cultivated in GR-contained MSCS scaffold had preferable abilities of proliferation and higher expression of the osteogenic-related protein and could effectively inhibit inflammation. Finally, in vivo performance was assessed using histological results that revealed the GR-contained MSCS scaffolds were able to further achieve more effective hard tissue regeneration than has been the case in the past. Taken together, this study demonstrated that a GR-containing MSCS 3D scaffold could be used as a potential alternative for future bone tissue engineering studies and has good potential for clinical use.

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“…A CT scan revealed complete healing after a six-month follow-up. In Lee’s research [ 87 ], a customized scaffold matched with an 8-shaped bone defect on the rabbit calvarium model was designed according to 3D computed tomography. they then implanted the scaffold in the defect area, which showed excellent mechanical robustness and enhanced osteoconductivity.…”

Section: Pcl-based Composite Scaffolds Utilized In Different Situationsmentioning

confidence: 99%

The Application of Polycaprolactone in Three-Dimensional Printing Scaffolds for Bone Tissue Engineering

et al. 2021

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Bone tissue engineering commonly encompasses the use of three-dimensional (3D) scaffolds to provide a suitable microenvironment for the propagation of cells to regenerate damaged tissues or organs. 3D printing technology has been extensively applied to allow direct 3D scaffolds manufacturing. Polycaprolactone (PCL) has been widely used in the fabrication of 3D scaffolds in the field of bone tissue engineering due to its advantages such as good biocompatibility, slow degradation rate, the less acidic breakdown products in comparison to other polyesters, and the potential for loadbearing applications. PCL can be blended with a variety of polymers and hydrogels to improve its properties or to introduce new PCL-based composites. This paper describes the PCL used in developing state of the art of scaffolds for bone tissue engineering. In this review, we provide an overview of the 3D printing techniques for the fabrication of PCL-based composite scaffolds and recent studies on applications in different clinical situations. For instance, PCL-based composite scaffolds were used as an implant surgical guide in dental treatment. Furthermore, future trend and potential clinical translations will be discussed.

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Evaluation of mechanical strength and bone regeneration ability of 3D printed kagome-structure scaffold using rabbit calvarial defect model

Cited by 56 publications

References 40 publications

The combination of a poly‐caprolactone/nano‐hydroxyapatite honeycomb scaffold and mesenchymal stem cells promotes bone regeneration in rat calvarial defects

The combination of a poly‐caprolactone/nano‐hydroxyapatite honeycomb scaffold and mesenchymal stem cells promotes bone regeneration in rat calvarial defects

3D-Printed Ginsenoside Rb1-Loaded Mesoporous Calcium Silicate/Calcium Sulfate Scaffolds for Inflammation Inhibition and Bone Regeneration

The Application of Polycaprolactone in Three-Dimensional Printing Scaffolds for Bone Tissue Engineering

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