Evaluation of Mean Platelet Volume in Patients With Rheumatoid Arthritis and its Relation With Severity of Disease

Khodashahi, Mandana; Saadati, Nayyereh; Rezaieyazdi, Zahra; Sahebari, Maryam; Saremi, Zeinab

doi:10.22631/rr.2019.69997.1075

Cited by 3 publications

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“…Following a full-text revision of the remaining 27 articles, four were further excluded because they did not have a healthy control group. Thus, 23 studies were included in the final analysis ( Figure 1 ) [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ]. There was no disagreement between the two independent investigators.…”

Section: Resultsmentioning

confidence: 99%

“…Seventeen studies in 1489 RA patients (mean age 53 years, 77% females) and 1082 healthy controls (mean age 54 years, 71% females) reported data on the MPV [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 37 , 39 , 41 , 42 , 43 , 45 , 46 , 47 , 50 ]. Eleven studies were performed in Turkey [ 28 , 30 , 31 , 32 , 33 , 34 , 35 , 39 , 41 , 45 , 47 ], two in Egypt [ 46 , 50 ], and one in Romania [ 29 ], India [ 37 ], China [ 42 ], and Iran [ 43 ], respectively. Eleven studies were prospective [ 29 , 30 , 32 , 34 , 37 , 41 , 43 , 45 , 46 , 47 , 50 ] and six retrospective ( Table 1 ) [ 28 , 31 ...…”

Section: Resultsmentioning

confidence: 99%

“…Eleven studies were performed in Turkey [ 28 , 30 , 31 , 32 , 33 , 34 , 35 , 39 , 41 , 45 , 47 ], two in Egypt [ 46 , 50 ], and one in Romania [ 29 ], India [ 37 ], China [ 42 ], and Iran [ 43 ], respectively. Eleven studies were prospective [ 29 , 30 , 32 , 34 , 37 , 41 , 43 , 45 , 46 , 47 , 50 ] and six retrospective ( Table 1 ) [ 28 , 31 , 33 , 35 , 39 , 42 ].…”

Section: Resultsmentioning

confidence: 99%

“…The risk of bias was considered low in all studies ( Table 2 ) [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 37 , 39 , 41 , 42 , 43 , 45 , 46 , 47 , 50 ].…”

Section: Resultsmentioning

confidence: 99%

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Platelet and Red Blood Cell Volume Indices in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

Zinellu

Mangoni

2022

Diagnostics

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Alterations in the volume of platelets (mean platelet volume, MPV; platelet distribution width, PDW) and erythrocytes (red blood cell distribution width, RDW) have been reported in rheumatoid arthritis (RA) and might serve as diagnostic biomarkers. We conducted a systematic review and meta-analysis of the MPV, PDW, and RDW in RA patients and healthy controls. Relevant articles were searched in PubMed, Web of Science, Scopus, and Google Scholar from inception to June 2022. Risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Checklist and certainty of evidence was assessed using GRADE. In 23 studies (2194 RA patients and 1565 healthy controls), the RDW, but not MPV or PDW, was significantly higher in RA patients (standardized mean difference, SMD = 0.96, 95% CI 0.78 to 1.15, p < 0.001; moderate certainty of evidence). The substantial heterogeneity observed (I2 = 75.1%, p < 0.001) was virtually removed in a subgroup of prospective studies. In sensitivity analysis, the magnitude of the effect size was not substantially modified by sequentially removing individual studies. There was no significant publication bias. No significant associations were observed between the effect size and pre-defined study or patient characteristics. The results of our study suggest that the RDW might be a useful biomarker for the diagnosis of RA, and complement the clinical information provided by other patient characteristics and laboratory parameters (PROSPERO registration number: CRD42022349432).

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…The risk of bias was considered low in all studies ( Table 2 ) [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 37 , 39 , 41 , 42 , 43 , 45 , 46 , 47 , 50 ].…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Platelet and Red Blood Cell Volume Indices in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

Zinellu

Mangoni

2022

Diagnostics

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The role of platelets in immune-mediated inflammatory diseases

et al. 2023

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Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and uncontrolled inflammation and thrombosis, both of which are responsible for organ damage, morbidity and death. Platelets have long been known for their role in primary haemostasis, but they are now also considered to be components of the immune system and to have a central role in the pathogenesis of IMIDs. In patients with IMIDs, platelets are activated by disease-specific factors, and their activation often reflects disease activity. Here we summarize the evidence showing that activated platelets have an active role in the pathogenesis and the progression of IMIDs. Activated platelets produce soluble factors and directly interact with immune cells, thereby promoting an inflammatory phenotype. Furthermore, platelets participate in tissue injury and promote abnormal tissue healing, leading to fibrosis. Targeting platelet activation and targeting the interaction of platelets with the immune system are novel and promising therapeutic strategies in IMIDs.

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Value of mean platelets volume in children with familial mediterranean fever: A case–control prospective study from Sulaymaniyah, Kurdistan Region, Iraq

Mohammad

2021

Iraqi J Hematol

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Evaluation of Mean Platelet Volume in Patients With Rheumatoid Arthritis and its Relation With Severity of Disease

Cited by 3 publications

References 0 publications

Platelet and Red Blood Cell Volume Indices in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

Platelet and Red Blood Cell Volume Indices in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

The role of platelets in immune-mediated inflammatory diseases

Value of mean platelets volume in children with familial mediterranean fever: A case–control prospective study from Sulaymaniyah, Kurdistan Region, Iraq

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