Evaluation of marrow cellularity in alcoholism and hepatic cirrhosis, by aspiration, biopsy and histomorphometric

Batista, J.N.; Santolaria, Francisco; González‐Reimers, Emilio; Brito‐Barroso, María L.; Jorge-Hernandes, J.A.; L, Marsa; Hernández-Nieto, L

doi:10.1016/0376-8716(88)90033-6

Cited by 5 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These depots are depleted during negative energy balance [43]. In contrast, a negative energy balance results in increased bone marrow adiposity [44–48]. Also, during starvation bone marrow adipocytes sequester and esterify fatty acids [49–54].…”

Section: Discussionmentioning

confidence: 99%

Low dose parathyroid hormone maintains normal bone formation in adult male rats during rapid weight loss

Turner

Iwaniec

2011

Bone

View full text Add to dashboard Cite

A persistent negative energy balance results in bone loss. It is not clear whether the bone loss associated with chronic negative energy balance can be prevented. The objective of this study was to assess the efficacy of intermittent low dose parathyroid hormone (PTH) treatment in maintaining normal bone formation during severe energy restriction. Six-month-old male Fisher 344 rats were divided into 4 treatment groups: (1) baseline, (2) ad libitum (ad lib)-fed control, (3) energy-restricted (to consume 40% ad lib caloric intake), or (4) energy-restricted + low dose (1 μg/kg/d) PTH. Severe energy restriction for 14 days decreased body weight and serum leptin levels. Compared to ad lib-fed controls, energy-restricted rats had lower cancellous bone formation, higher osteoclast perimeter/bone perimeter and higher bone marrow adiposity in the proximal tibial metaphysis. Also, the energy-restricted rats had a lower periosteal bone formation rate at the tibia-fibula synostosis. Administration of PTH to energy-restricted rats had no effect on weight loss or osteoclast perimeter/bone perimeter. In contrast, energy-restricted rats treated with PTH had higher rates of cancellous and cortical bone formation compared to energy-restricted rats, and did not differ from the ad lib-fed control animals. Furthermore, PTH treatment maintained normal bone marrow adiposity. In conclusion, rapid weight loss in adult male rats was accompanied by decreased bone formation and increased bone marrow adiposity and these changes were prevented by low dose PTH treatment. Taken together, the results suggest that the energy cost of bone formation in adult rats is low and PTH therapy is effective in preventing the reduced bone formation associated with rapid weight loss.

show abstract

Section: Discussionmentioning

confidence: 99%

Low dose parathyroid hormone maintains normal bone formation in adult male rats during rapid weight loss

Turner

Iwaniec

2011

Bone

View full text Add to dashboard Cite

show abstract

“…During severe caloric restriction, fat catabolism becomes an important source of energy and peripheral fat depots decline in mass. In contrast, severe caloric restriction is associated with increased bone marrow adiposity (Batista et al, 1988;Bohm, 2000;Cui et al, 2006;Duque, 2008;Bredella et al, 2009). Bone marrow adipocytes sequester and esterify fatty acids during starvation, a finding which has fostered the belief that the bone marrow fat depot does not function as an important energy reservoir for peripheral tissues (Tavassoli, 1974;Bathija et al, 1979;Tran et al, 1981;Gimble et al, 1996;Abella et al, 2002).…”

mentioning

confidence: 99%

Effect of Reduced c‐Kit Signaling on Bone Marrow Adiposity

Turner

Wong

Iwaniec

2011

The Anatomical Record

View full text Add to dashboard Cite

c-Kit (CD117) is required for normal differentiation of osteoblasts from bone marrow stromal cells and for normal bone formation. Osteoblasts and adipocytes originate from a common progenitor cell, and a reciprocal relationship in differentiation of the two lineages is often observed. Therefore, the effects of abnormal c-kit signaling on bone marrow adiposity and adipocyte precursor pool size were evaluated in mouse strains with loss of function mutations in kit receptor or kit ligand. Additionally, to determine whether short-duration pharmacological disruption of kit signaling influences bone marrow adiposity, we administered the kit receptor antagonist gleevec (imatinib mesilate) for 1 week to middle aged (13-month-old) male rats known to have high levels of bone marrow fat. Compared to wild-type littermates, adipocytes were absent and adipocyte precursors greatly reduced in bone marrow from kit receptor-deficient Kit W/W-m mice. Administration of secreted kit ligand to membrane-associated kit ligand-deficient Kit Sl/Sl-d mice was ineffective in inducing bone marrow adipogenesis. These findings suggest that activation of kit receptor by the membrane-associated form of kit ligand is required for kit signaling to promote bone marrow adipogenesis in mice. Rats treated with gleevec had lower adipocyte density compared to age-matched controls, suggesting that kit signaling is required to maintain normal bone marrow adiposity. Taken together, our results indicate that c-Kit signaling plays an important but previously unsuspected role in regulating bone marrow adiposity. Anat Rec, 294:1126Rec, 294: -1134Rec, 294: , 2011. V V C 2011 Wiley-Liss, Inc.Key words: hematopoietic stem cell; mesenchymal stem cell; adipocyte; mast cell; receptor tyrosine kinase; gleevec (imatinib mesilate)Osteoblasts and adipocytes are derived from a common bone marrow progenitor (Prockop, 1997;Vaananen, 2005;Valtieri and Sorrentino, 2008). The primary function of osteoblasts is well defined. Osteoblasts generate bone matrix to support bone growth, turnover, and remodeling. Additionally, osteoblasts have been reported to participate in hematopoietic stem cell mobilization from their bone marrow niche and to support hematopoiesis (Nagayoshi et al., 2006;Mayack and Wagers, 2008). In contrast, the physiological significance of adipocytes residing within bone marrow is less well defined.Most fat depots act as dynamic energy reservoirs to maintain circulating triglyceride and free fatty acid levels (Caserta et al., 2001). During severe caloric restriction, fat catabolism becomes an important source of energy and peripheral fat depots decline in mass. In contrast, severe caloric restriction is associated with increased bone marrow adiposity (Batista et al., 1988;Bohm, 2000;Cui et al., 2006;Duque, 2008;Bredella et al., 2009). Bone marrow adipocytes sequester and esterify fatty acids during starvation, a finding which has fostered the belief that the bone marrow fat depot does not function as an important energy reservoir for peripheral tissu...

show abstract

Long-term Management of Alcoholic Liver Disease

Wakim-Fleming

Mullen

2005

Clinics in Liver Disease

View full text Add to dashboard Cite

Despite the epidemics of viral hepatitis C and nonalcoholic fatty liver disease, alcohol remains one of the major causes of liver disease. Commonly, hepatitis C and other liver diseases are found in association with alcohol consumption. This association in many instances is noted to accelerate the progression of liver disease. In many respects, the long-term management of alcoholic liver disease is not dissimilar from the long-term management of patients with cirrhosis from other etiologies. One major element is the abstinence of alcohol use. The ability to maintain sobriety has a major impact on the outcome of patients with alcoholic cirrhosis because maintaining abstinence can lead to significant regression of fibrosis and possibly early cirrhosis. Similarities in managing patients with cirrhosis due to alcohol or cirrhosis from other causes include vaccination to prevent superimposed viral hepatitis and screening for esophageal varices and hepatocellular carcinoma with subsequent appropriate therapy.

show abstract

Evaluation of marrow cellularity in alcoholism and hepatic cirrhosis, by aspiration, biopsy and histomorphometric

Cited by 5 publications

References 3 publications

Low dose parathyroid hormone maintains normal bone formation in adult male rats during rapid weight loss

Low dose parathyroid hormone maintains normal bone formation in adult male rats during rapid weight loss

Effect of Reduced c‐Kit Signaling on Bone Marrow Adiposity

Long-term Management of Alcoholic Liver Disease

Contact Info

Product

Resources

About