Evaluation of marble-burying behavior as a model of anxiety

Njung'e, K.; Handley, Sheila L.

doi:10.1016/0091-3057(91)90590-x

Cited by 424 publications

(308 citation statements)

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“…A number of alternative tasks for assessing anxiety-related behaviors in mice avoid this drawback; for instance, in active-avoidance tasks, mice direct their energies toward minimizing threatening stimuli. Rodents will bury an electrified probe following conditioning in which they receive shocks from the probe 43 , and will even spontaneously bury novel marbles introduced into their home cages 44 . This burying behavior is quantifiable and sensitive to anxiolytics 45,46 .…”

Section: Measuring Anxiety-related Behaviors In Rodentsmentioning

confidence: 99%

Resolving the neural circuits of anxiety

2015

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Although anxiety disorders represent a major societal problem demanding new therapeutic targets, these efforts have languished in the absence of a mechanistic understanding of this subjective emotional state. While it is impossible to know with absolute certainty the subjective experience of a rodent, rodent models hold promise in dissecting wellconserved limbic circuits. The application of modern approaches in neuroscience has already begun to unmask the neural circuit intricacies underlying anxiety by allowing direct examination of hypotheses drawn from existing psychological concepts. This information points toward an updated conceptual model for what neural circuit perturbations could give rise to pathological anxiety, and thereby provides a roadmap for future therapeutic development.3

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Section: Measuring Anxiety-related Behaviors In Rodentsmentioning

confidence: 99%

Resolving the neural circuits of anxiety

2015

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“…The MB test was performed as a modified version (Li et al, 2006) of the test originally described for testing mice (Broekkamp et al, 1986, Njung'e and Handley, 1991, Borsini et al, 2002, Nicolas et al, 2006, Egashira et al, 2007. The rats were placed individually in a plexiglass cage (41.3cm x 26 cm x 29.8 cm high, Ferplast, Geo Maxi, Italy) with a 5 cm deep layer of bedding holding 15 marbles on its surface (25 mm diameter; arranged in a 3 x 5 pattern; space between two marbles ~ 4.5 cm).…”

Section: 5 Marble Buryingmentioning

confidence: 99%

Restoration of peripheral V2 receptor vasopressin signaling fails to correct behavioral changes in Brattleboro rats

Balázsfi

Pintér

Klausz

et al. 2015

Psychoneuroendocrinology

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Short title:Stress-related behavior in Brattleboro rat after DDAVP treatment You created this PDF from an application that is not licensed to print to novaPDF printer (http://www.novapdf.com) Balázsfi et al. 2Highlights  The effect of AVP on affective and memory symptoms is due to its central role  DDAVP treatment compensated the peripheral effects of congenital AVP absence  DDAVP did not significantly alter the behavior of KO animals in the paradigms tested  AVP signaling in the medial amygdala contributes to the behavioral effect measured in FS AbstractBeside its hormonal function in salt and water homeostasis, vasopressin -released into distinct brain areas -plays a crucial role in stress-related behavior resulting in the enhancement of an anxious/depressive-like state.We aimed to investigate whether correction of the peripheral symptoms of congenital absence of AVP also corrects the behavioral alterations in AVP-deficient Brattleboro rats. Wild type (WT) and vasopressin-deficient (KO) male Brattleboro rats were tested.Half of the KO animals were treated by desmopressin (V2-receptor agonist) via osmotic minipump (subcutaneous) to eliminate the peripheral symptoms of vasopressin-deficiency. Anxiety was studied by elevated plus maze (EPM), defensive withdrawal (DW) and marble burying (MB) tests, while depressive-like changes were monitored in forced swimming (FS) and anhedonia by sucrose preference test. Cell activity was examined in septum and amygdala by c-Fos immunohistochemistry after 10min FS.

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“…Establishing good animal models for OCD has proved to be exceedingly difficult, most clearly demonstrated by the large number of models tried [21,23]. Marble burying is one of the more well-established models for OCD [19,27,28]. New models of supposedly stereotypic behavior, such as the screen chewing and head dipping tests used along with marble burying in the present study, are also continuously being developed and tested [2].…”

mentioning

confidence: 95%

“…Marble burying is one of the more well-established models for OCD [19,27,28]. New models of supposedly stereotypic behavior, such as the screen chewing and head dipping tests used along with marble burying in the present study, are also continuously being developed and tested [2].…”

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confidence: 97%

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The 5-HT7 receptor influences stereotypic behavior in a model of obsessive-compulsive disorder

Hedlund

Sutcliffe

2007

Neuroscience Letters

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The 5-HT 7 receptor has been suggested as a new putative target for the treatment of neuropsychiatric disorders, especially depression. This hypothesis is based on the finding that antidepressant drugs have relatively high affinity for the 5-HT 7 receptor, and that inactivation or blockade of the receptor leads to an antidepressant-like profile in behavioral models and sleep parameters. Obsessivecompulsive disorder is also believed to involve the serotonergic system and is treated using antidepressants, thus it is of interest to study the possible role of the 5-HT 7 receptor in this disorder. We have evaluated the effect of inactivation or pharmacological blockade of the 5-HT 7 receptor in three mouse behavioral models that are believed to mimic some of the stereotypic aspects of obsessive-compulsive disorder. In the most well established behavioral model, marble burying, both inactivation and blockade of the 5-HT 7 receptor reduced stereotypic behavior in that the number of marbles buried decreased. In two newer, less well characterized models, head dipping and plasticmesh screen chewing, there was no difference between wild-type mice and mice lacking the 5-HT 7 receptor. Taken together the data confirms and expands on previous findings that the 5-HT 7 receptor is of importance for behaviors affected by antidepressants, and suggests that the 5-HT 7 receptor might be of relevance as a target for the treatment of obsessive-compulsive disorder. Keywordsserotonin; marble burying; head dipping; screen chewing; SB-269970The 5-HT 7 receptor, one of the most recently discovered receptors for serotonin [12], has been found to modulate behaviors affected by antidepressant drugs. In both the forced swim test and the tail suspension test, inactivation or blockade of the 5-HT 7 receptor lead to antidepressantlike behavior [7,13,35]. Furthermore, inactivation or pharmacological blockade of the 5-HT 7 receptor lead to changes in rapid eye movement sleep that are opposite to those seen in depression [8,13]. In addition, it has been shown that certain antidepressants might exert some of their effects by acting directly at the 5-HT 7 receptor [26].Obsessive-compulsive disorder (OCD) is a debilitating disease with an overall prevalence of close to 1 % [15]. There is strong evidence in support of a significant role for 5-HT in OCD and antidepressant drugs, mainly selective serotonin reuptake inhibitors (SSRIs), are the pharmacological treatment of choice for OCD [4,15]. However, as many as 40 % of patients do not respond to currently available treatment options [15], so continued research is necessary. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the c...

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Evaluation of marble-burying behavior as a model of anxiety

Cited by 424 publications

References 13 publications

Resolving the neural circuits of anxiety

Resolving the neural circuits of anxiety

Restoration of peripheral V2 receptor vasopressin signaling fails to correct behavioral changes in Brattleboro rats

The 5-HT7 receptor influences stereotypic behavior in a model of obsessive-compulsive disorder

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