Evaluation of Malignancy Grade of Breast Cancer Using Perflubutane-Enhanced Ultrasonography

Masumoto, Norio; Kadoya, Takayuki; Amioka, Ai; Kajitani, Keiko; Shigematsu, Hideo; Emi, Akiko; Matsuura, Kazuo; Arihiro, Koji; Okada, Minoru

doi:10.1016/j.ultrasmedbio.2015.12.023

Cited by 12 publications

(15 citation statements)

References 30 publications

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“…Several studies identified heterogeneity in the expression of vascular endothelial growth factor (VEGF) using CEUS . Masumoto and colleagues found that perfusion parameters on CEUS were significantly associated with ER, Her‐2, and Ki‐67 status . This result is consistent with other studies .…”

Section: Ultrasoundsupporting

confidence: 70%

Progress in the clinical detection of heterogeneity in breast cancer

et al. 2016

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Breast cancer is currently the most common form of cancer and the second‐leading cause of death from cancer in women. Though considerable progress has been made in the treatment of breast cancer, the heterogeneity of tumors (both inter‐ and intratumor) remains a considerable diagnostic and prognostic challenge. From clinical observation to genetic mutations, the history of understanding the heterogeneity of breast cancer is lengthy and detailed. Effectively detecting heterogeneity in breast cancer is important during treatment. Various methods of depicting this heterogeneity are now available and include genetic, pathologic, and imaging analysis. These methods allow characterization of the heterogeneity of breast cancer on a genetic level, providing greater insight during the process of establishing an effective therapeutic plan. This study reviews how the understanding of tumor heterogeneity in breast cancer evolved, and further summarizes recent advances in the detection and monitoring of this heterogeneity in patients with breast cancer.

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Section: Ultrasoundsupporting

confidence: 70%

Progress in the clinical detection of heterogeneity in breast cancer

et al. 2016

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“…Regarding the early diagnosis of TNBC, previous study showed that values of perfusion parameters on contrast-enhanced US were significantly greater in estrogen receptor-negative tumors than that in estrogen receptor-positive tumors, indicating that perfusion parameters on contrast-enhanced US have good predictive value for estrogen receptor-negative tumors. [ 12 ] Çelebi et al [ 13 ] found that US characteristics are closely associated with the molecular subtype, histological grade and hormone receptor status of the tumor, tumors showing posterior attenuating were more often non-triple negative subtype, and tumors with circumscribed margins were more often triple-negative subtype. Krizmanich-Conniff et al [ 14 ] indicated that TNBC frequently manifested as an irregular, non-calcified mass with ill-defined or spiculated margins on mammography.…”

Section: Discussionmentioning

confidence: 99%

Identify the triple-negative and non-triple-negative breast cancer by using texture features of medicale ultrasonic image

Chen¹,

Xia²,

Zhang

2021

Medicine

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The study aimed to explore the value of ultrasound (US) texture analysis in the differential diagnosis of triple-negative breast cancer (TNBC) and non-TNBC. Retrospective analysis was done on 93 patients with breast cancer (35 patients with TNBC and 38 patients with non-TNBC) who were admitted to Taizhou people's hospital from July 2015 to June 2019. All lesions were pathologically proven at surgery. US images of all patients were collected. Texture analysis of US images was performed using MaZda software package. The differences between textural features in TNBC and non-TNBC were assessed. Receiver operating characteristic curve analysis was used to compare the diagnostic performance of textural parameters showing significant difference. Five optimal texture feature parameters were extracted from gray level run-length matrix, including gray level non-uniformity (GLNU) in horizontal direction, vertical gray level non-uniformity, GLNU in the 45 degree direction, run length non-uniformity in 135 degree direction, GLNU in the 135 degree direction. All these texture parameters were statistically higher in TNBC than in non-TNBC ( P <.05). Receiver operating characteristic curve analysis indicated that at a threshold of 268.9068, GLNU in horizontal direction exhibited best diagnostic performance for differentiating TNBC from non-TNBC. Logistic regression model established based on all these parameters showed a sensitivity of 69.3%, specificity of 91.4% and area under the curve of 0.834. US texture features were significantly different between TNBC and non-TNBC, US texture analysis can be used for preliminary differentiation of TNBC from non-TNBC.

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“…Comparing clinical findings for various breast cancer types, tumours of patients with TNBC show the largest amount of microbubble perfusion when using contrast enhanced ultrasound indicating the potential for ACT in treating patients with TNBC (Masumoto et al, 2016).…”

Section: Imaging Biomarkers Of Therapeutic Responsementioning

confidence: 99%

Theranostic Attributes of Acoustic Cluster Therapy and Its Use for Enhancing the Effectiveness of Liposomal Doxorubicin Treatment of Human Triple Negative Breast Cancer in Mice

et al. 2020

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Introduction: Acoustic cluster therapy (ACT) comprises co-administration of a formulation containing microbubble/microdroplet clusters (PS101), together with a regular medicinal drug (e.g., a chemotherapeutic) and local ultrasound (US) insonation of the targeted pathological tissue (e.g., the tumor). PS101 is confined to the vascular compartment and, when the clusters are exposed to regular diagnostic imaging US fields, the microdroplets undergo a phase-shift to produce bubbles with a median diameter of 22 µm when unconstrained by the capillary wall. In vivo these bubbles transiently lodge in the tumor's microvasculature. Low frequency ultrasound (300 kHz) at a low mechanical index (MI = 0.15) is then applied to drive oscillations of the deposited ACT bubbles to induce a range of biomechanical effects that locally enhance extravasation, distribution, and uptake of the coadministered drug, significantly increasing its therapeutic efficacy.Methods: In this study we investigated the therapeutic efficacy of ACT with liposomal doxorubicin for the treatment of triple negative breast cancer using orthotopic human tumor xenografts (MDA-MB-231-H.luc) in athymic mice (ICR-NCr-Foxn1 nu ). Doxil ® (6 mg/kg, i.v.) was administered at days 0 and 21, each time immediately followed by three sequential ACT (20 ml/kg PS101) treatment procedures (n = 7-10). B-mode and nonlinear ultrasound images acquired during the activation phase were correlated to the therapeutic efficacy.Results: Results show that combination with ACT induces a strong increase in the therapeutic efficacy of Doxil ® , with 63% of animals in complete, stable remission at end of study, vs. 10% for Doxil ® alone (p < 0.02). A significant positive correlation (p < 0.004) was found between B-mode contrast enhancement during ACT activation and therapy response. These observations indicate that ACT may also be used as a theranostic Frontiers in Pharmacology | www.frontiersin.org

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Evaluation of Malignancy Grade of Breast Cancer Using Perflubutane-Enhanced Ultrasonography

Cited by 12 publications

References 30 publications

Progress in the clinical detection of heterogeneity in breast cancer

Progress in the clinical detection of heterogeneity in breast cancer

Identify the triple-negative and non-triple-negative breast cancer by using texture features of medicale ultrasonic image

Theranostic Attributes of Acoustic Cluster Therapy and Its Use for Enhancing the Effectiveness of Liposomal Doxorubicin Treatment of Human Triple Negative Breast Cancer in Mice

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