Evaluation of magnifying colonoscopy in the diagnosis of serrated polyps

Ishigooka, Shinya; Nomoto, Masahito; Obinata, Nobuyuki; Oishi, Yoshichika; Sato, Yoshinori; Nakatsu, Satoko; Suzuki, Midori; Ikeda, Yoshiko; Maehata, Tadateru; Kimura, Tomoaki; Watanabe, Yoshiyuki; Nakajima, Takashi; Yamano, Hiro O.; Yasuda, Hiroshi; Itoh, Fumio

doi:10.3748/wjg.v18.i32.4308

Cited by 49 publications

(47 citation statements)

References 37 publications

(48 reference statements)

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“…In this study, only one lesion (1.3%) presented a type II pit pattern, suggestive of a non-neoplastic lesion, however, after endoscopic resection, it was revealed to be a sessile serrated adenoma, a lesion that could be mistaken for a hyperplastic lesion at colonoscopy (10) . Among the five lesions with type V pit pattern, histology showed one adenoma with high-grade dysplasia, three intramucosal carcinomas and one invasive carcinoma, which was surgically treated later.…”

Section: Discussioncontrasting

confidence: 54%

Malignancy in Large Colorectal Lesions

Santos

Malaman

Carvalho

et al. 2014

Arq. Gastroenterol.

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-Context -The size of colorectal lesions, besides a risk factor for malignancy, is a predictor for deeper invasion. Objective -To evaluate the malignancy of colorectal lesions >20 mm. Methods -Between 2007 and 2011, 76 neoplasms >20 mm in 70 patients were analyzed. Results -The mean age of the patients was 67.4 years, and 41 were women. Mean lesion size was 24.7 mm + 6.2 mm (range: 20 to 50 mm). Half of the neoplasms were polypoid and the other half were non-polypoid. Forty-two (55.3%) lesions were located in the left colon, and 34 in the right colon. There was a high prevalence of III L (39.5%) and IV (53.9%) pit patterns. There were 72 adenomas and 4 adenocarcinomas. Malignancy was observed in 5.3% of the lesions. Thirty-three lesions presented advanced histology (adenomas with high-grade dysplasia or early adenocarcinoma), with no difference in morphology and site. Only one lesion (1.3%) invaded the submucosa. Lesions larger than 30 mm had advanced histology (P = 0.001). The primary treatment was endoscopic resection, and invasive carcinoma was referred to surgery. Recurrence rate was 10.6%. Conclusions -Large colorectal neoplasms showed a low rate of malignancy. Endoscopic treatment is an effective therapy for these lesions. HEADINGS -Colonic polyps. Colorectal neoplasms. Gastrointestinal endoscopy.

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Section: Discussioncontrasting

confidence: 54%

Malignancy in Large Colorectal Lesions

Santos

Malaman

Carvalho

et al. 2014

Arq. Gastroenterol.

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“…With regard to the differential diagnosis, the specificity and PPV of the Type II-O pit pattern were sufficient, whereas the sensitivity and NPV were not. These results are similar to those reported previously 11,19 . However, in the present study, VMVs had lower diagnostic accuracy than those reported by Uraoka et al 12 .…”

Section: Discussionsupporting

confidence: 93%

Magnifying Colonoscopy Findings for Differential Diagnosis of Sessile Serrated Adenoma/Polyps and Hyperplastic Polyps

Toshihiro:筆頭著者

Yutaro:責任著者

Konishi

et al. 2016

Showa Univ J Med Sci

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: Sessile serrated adenoma / polyps SSA / Ps are thought to be precursors of colorectal cancers. However, current endoscopic techniques for differentiating SSA / Ps from conventional hyperplastic polyps HPs have low diagnostic accuracy. The aim of the present study was to assess the ability of mucosal crypt patterns to distinguish SSA / Ps from HPs. We examined 140 lesions from 93 patients that had been diagnosed histologically as SSA / Ps or HPs at the Showa University Hospital between June 2010 and May 2012. Three experienced colonoscopists reviewed the endoscopic ndings of magnifying colonoscopy. Type II open-shape Type II-O pit patterns and varicose microvascular vessels VMVs were identi ed according to previously proposed de nitions. Although 140 lesions were initially identi ed for the study, 27 lesions were excluded from analysis because of insuf cient endoscopic ndings. Thus, endoscopic ndings from a total of 113 lesions 68 SSA / Ps and 45 HPs were evaluated. Of 113 serrated polyps, 51 lesions 44 SSA / Ps and 7 HPs ; P 0.01 had Type II-O pit patterns. The inter-and intra-observer agreement for these patterns among three colonoscopists was 0.61 range 0.57-0.65 and 0.68 range 0.52-0.94 , respectively. The positive predictive value PPV , negative predictive value NPV , sensitivity, and speci city of Type II-O pit patterns for differentiating between SSA / P and HP were 86 , 61 , 65 , and 84 , respectively. In contrast, the PPV, NPV, sensitivity, and speci city of VMVs were 68 , 43 , 37 , and 73 , respectively. The results indicate that Type II-O mucosal crypt patterns may be useful for the differential diagnosis of SSAPs and HPs.

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“…Согласно результа там, полученным М. Агаповым и соавт., и IIО тип кишечных ямок, и налет муцина на поверхности об разования обладают относительно низкой чувстви тельностью и высокой специфичностью при диф ференциальной диагностике зубчатых аденом от гиперпластических полипов, составляя соответ ственно 60 и 97% [42]. Другие авторы сообщают о более высокой чувствительности (84%) и более низ кой специфичности (86%) типа IIО кишечных ямок при дифференциальной диагностике зубчатых аденом от гиперпластических полипов [45].…”

Section: доказательная гастроэнтерология 4 2016unclassified

Serrated lesions of the colon

Веселов¹

2016

Dok. gastroenterol.

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Evaluation of magnifying colonoscopy in the diagnosis of serrated polyps

Abstract: We suggest that this system could be a good diagnostic tool for SSA/Ps using magnifying colonoscopy.

Cited by 49 publications

References 37 publications

Malignancy in Large Colorectal Lesions

Malignancy in Large Colorectal Lesions

Magnifying Colonoscopy Findings for Differential Diagnosis of Sessile Serrated Adenoma/Polyps and Hyperplastic Polyps

Serrated lesions of the colon

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