Evaluation of Macular Thickness and Peripapillary Retinal Nerve Fiber Layer Thickness for Detection of Early Glaucoma Using Spectral Domain Optical Coherence Tomography

Nakatani, Yusuke; Higashide, Tomomi; Ohkubo, Shinji; Takeda, Hisashi; Sugiyama, Kazuhisa

doi:10.1097/ijg.0b013e3181e079ed

Cited by 152 publications

(112 citation statements)

References 20 publications

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“…This approach does not depend on averaging the thickness of the area ( ¼ thickness divided by area) that has been used in most of the earlier studies for glaucoma detection using OCT. [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] Calculating the average thickness with this area underestimates the local RGC loss as it takes into account the area with a normal or less affected RGC population. Although this averaging effect would decrease in sector analysis, it would remain present when the area with local RGC loss is smaller than the sectors or across multiple sectors.…”

Section: Discussionmentioning

confidence: 99%

“…Regional thickness using predefined sectors, such as the Early Treatment Diabetic Retinopathy Study (ETDRS) and glaucoma sector charts, has been used to detect local macular RGC loss. [14][15][16][17][18][19][20][21] However, the same averaging effects may be present within the sectors, and developing a predefined sector that encloses the entire area with local RGC loss is difficult because areas of RGC loss differ from patient to patient. We explored a new approach for detecting local loss of macular RGCs by using the lowest ganglion cell-inner plexiform layer thickness (GCIPL) among the 360 spokes (termed ''minimum GCIPL'') based on ganglion cell analysis in a macular elliptical annulus developed on a macular cube scan with OCT software (Cirrus HD-OCT; Carl Zeiss Meditec, Inc., Dublin, CA).…”

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confidence: 99%

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A Novel Method to Detect Local Ganglion Cell Loss in Early Glaucoma Using Spectral-Domain Optical Coherence Tomography

Takayama

Hangai

Durbin

et al. 2012

Invest. Ophthalmol. Vis. Sci.

112

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PURPOSE.To test the glaucoma-discriminating ability of a new method for detecting local ganglion cell loss using spectraldomain optical coherence tomography (OCT).METHODS. This study included 58 glaucomatous and 48 healthy eyes from Japanese subjects. Combined thickness of the ganglion cell layer and inner plexus layer (GCIPL) was measured on a macular cube scan in Cirrus HD-OCT. Average GCIPL thickness within a macular elliptical annulus and minimum GCIPL thickness on 360 spokes extending from the inner to the outer radius of the elliptical annulus were calculated. Area under the receiver operating characteristic curve (AROC) to discriminate between healthy eyes and early (mean deviation [MD], ‡À6 dB)/advanced (MD, <À6 dB) glaucomatous were compared between parameters.RESULTS. Forty-three were normal-tension glaucoma, and 15 were high-tension glaucoma. The mean minimum GCIPL thickness was 77.0 lm in healthy eyes and 60.6 lm in glaucomatous eyes (P < 0.001). For the intersession repeatability, the coefficients of variation for average GCIPL and minimum GCIPL were 0.98 and 1.85 in glaucomatous eyes, and 0.89 and 1.85 in healthy eyes, respectively. Minimum GCIPL thickness AROC (0.896) was significantly higher (P ¼ 0.0062) than average GCIPL thickness (0.821) for early glaucoma, whereas minimum GCIPL AROC (0.991) was comparable (P ¼ 0.103) to average GCIPL (0.964) for advanced glaucoma. The minimum GCIPL thickness AROC was comparable (P ¼ 0.861) to average circumpapillary retinal nerve fiber layer (cpRNFL) thickness (0.890) for early glaucoma.CONCLUSIONS. In Japanese patients with 74.1% of normal-tension glaucoma, the minimum GCIPL on spokes may be useful for detecting early glaucoma. (Invest Ophthalmol Vis Sci. 2012; 53:6904-6913)

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

A Novel Method to Detect Local Ganglion Cell Loss in Early Glaucoma Using Spectral-Domain Optical Coherence Tomography

Takayama

Hangai

Durbin

et al. 2012

Invest. Ophthalmol. Vis. Sci.

112

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“…1 Therefore, a detailed evaluation of neuronal measures in relation to retinal vascular findings will broaden our understanding of this potentially sight-threatening condition. In this regard, optical coherence tomography (OCT) has been demonstrated as a noninvasive, repeatable, and effective technique 2 that can detect subtle neuroretinal degeneration in people with diabetes prior to the appearance of clinical signs of DR. [3][4][5][6][7][8][9][10][11][12][13][14][15][16] OCT is capable of quantifying structural changes at specific retinal layers and is being utilized in the monitoring of therapeutic interventions and in predicting the prognosis of retinal complications in diabetes. In addition to neuoretinal complications, recent studies have documented diabetes-related neural degeneration in the cornea in relation to the presence [17][18][19][20] and severity 21 of peripheral neuropathy, with the help of corneal confocal microscopy (CCM).…”

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confidence: 99%

Corneal and Retinal Neuronal Degeneration in Early Stages of Diabetic Retinopathy

Srinivasan

Dehghani

Pritchard

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To examine the neuronal structural integrity of cornea and retina as markers for neuronal degeneration in nonproliferative diabetic retinopathy (NPDR).METHODS. Participants were recruited from the broader Brisbane community, Queensland, Australia. Two hundred forty-one participants (187 with diabetes and 54 nondiabetic controls) were examined. Diabetic retinopathy (DR) was graded according to the Early Treatment Diabetic Retinopathy Study (ETDRS) scale. Corneal nerve fiber length (CNFL), corneal nerve branch density (CNBD), corneal nerve fiber tortuosity (CNFT), full retinal thickness, retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), focal (FLV) and global loss volumes (GLV), hemoglobin A 1c (HbA 1c ), nephropathy, neuropathy, and cardiovascular measures were examined.RESULTS. The central zone (P ¼ 0.174), parafoveal thickness (P ¼ 0.090), perifovea (P ¼ 0.592), RNFL (P ¼ 0.866), GCC (P ¼ 0.798), and GCC GLV (P ¼ 0.338) did not differ significantly between the groups. In comparison to the control group, those with very mild NPDR and those with mild NPDR had significantly higher focal loss in GCC volume (P ¼ 0.036). CNFL was significantly lower in those with mild NPDR (P ¼ 0.004) in comparison to the control group and those with no DR. The CNBD (P ¼ 0.094) and CNFT (P ¼ 0.458) did not differ between the groups.CONCLUSIONS. Both corneal and retinal neuronal degeneration may occur in early stages of diabetic retinopathy. Further studies are required to examine these potential markers for neuronal degeneration in the absence of clinical signs of DR.

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“…This has specifically enhanced the measurement of the three main retinal layers associated with glaucomatous damage, namely retinal nerve fiber layer, ganglion cell layer and inner plexiform layer, collectively called the ganglion cell complex (GCC). Previous studies using the time domain OCT have reported the peripapillary RNFL thickness parameters to have superior diagnostic ability than the macular thickness parameters in the diagnosis of early glaucoma [2] . However, many recent studies using the spectral domain (SD-OCT) have shown inconsistent results with better performance of macular parameters in a few of them [4,7] and equal performance [8,9,10] or even better performance of RNFL parameters [5,11] in others.…”

Section: Introductionmentioning

confidence: 99%

“…Ganglion cells (RGCs) and retinal nerve fiber layer (RNFL) constitute 30% to 35% of the macular retinal thickness. In addition, more than half the total number of ganglion cells (RGCs) in the retina are located in the central macula in more than one cell layer thickness [2,3] . Quantification of the changes that occur in the macula has hence been proposed to detect glaucoma in the early stages [3,4] .…”

Section: Introductionmentioning

confidence: 99%

Diagnostic utility of RNFL Thickness and Macular GCC Thickness in Primary Open Angle Glaucoma using Spectral Domain Optical Coherence Tomography in South Indian patients

Sidhan¹

2017

jmscr

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(-6.1 ± 3.5) and pattern standard deviation value of (5.3 ± 3.3). Significant differences between glaucoma and normal subjects were found for all tomographic parameters. The best parameters based on Receiver operating characteristic curves and sensitivity at 95% specificity were RNFL-Average (AROC, 0.960; sensitivity, 80%) and 0.912; sensitivity, 80%). Conclusions: Both retinal nerve fibre layer thickness parameters and macular Ganglion cell complex parameters showed good diagnostic abilities in the diagnosis of early glaucoma using the spectral domain Optical Coherence Tomography. Better performance of macular parameters (compared to previous observations using older -Time Domain-Optical Coherence Tomography) were noted in the current study, however they did not outperform RNFL parameters.

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Evaluation of Macular Thickness and Peripapillary Retinal Nerve Fiber Layer Thickness for Detection of Early Glaucoma Using Spectral Domain Optical Coherence Tomography

Abstract: For the diagnosis of early glaucoma by SD-OCT, macular parameters had high discriminating power and high reproducibility comparable with peripapillary RNFL parameters.

Cited by 152 publications

References 20 publications

A Novel Method to Detect Local Ganglion Cell Loss in Early Glaucoma Using Spectral-Domain Optical Coherence Tomography

A Novel Method to Detect Local Ganglion Cell Loss in Early Glaucoma Using Spectral-Domain Optical Coherence Tomography

Corneal and Retinal Neuronal Degeneration in Early Stages of Diabetic Retinopathy

Diagnostic utility of RNFL Thickness and Macular GCC Thickness in Primary Open Angle Glaucoma using Spectral Domain Optical Coherence Tomography in South Indian patients

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