Evaluation of Macroporous Biphasic HA-TCP Ceramic as a Bone Substitute

Abstract

To improve the efficiency of osteogenic repair, we developed macroporous biphasic HA-TCP ceramic as a bone substitute and evaluated its efficiency by evaluation of cellular toxicity, cellular attachment and proliferation rate, and osteogenic supportive effect. The biphasic hydroxyapatite (HA)-tricalcium phosphate (TCP) ceramic with macroporous structure has excellent biocompatibility and allows for favorable cellular attachment with acceleration of cellular proliferation and osteogenic differentiation support as well. Our data suggest that the macroporous biphasic HA-TCP ceramic can be a promising scaffold for scaffold-guided tissue regeneration technology, which has the potential to maximize the repair of large bone defects.