Evaluation of lymphovascular invasion as a prognostic predictor of overall survival after radical prostatectomy

Rakic, Nikola; Jamil, Marcus; Keeley, Jacob; Sood, Akshay; Vetterlein, Malte W.; Dalela, Deepansh; Arora, Sohrab; Modonutti, Daniele; Bronkema, Chandler; Novara, Giacomo; Peabody, James O.; Rogers, Craig G.; Menon, Mani; Abdollah, Firas

doi:10.1016/j.urolonc.2021.01.007

Cited by 6 publications

(7 citation statements)

References 27 publications

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“…Our data showed that PCa patients with LVI had higher risk including higher PSA levels, more advanced stage and grade, compared to their counterparts without LVI. These findings were robust and reliabe, in line with the previous studies ( 15 , 32 ), strongly indicating that LVI is an adverse clinicopathological characteristic. The regression analysis further confirmed that the three parameters were independent risk factors for LVI.…”

Section: Discussionsupporting

confidence: 90%

“…There are multiple lines of evidence supporting that LVI is an independent predictor of BCR and progression and has been associated with metastasis and decreased survival after RP ( 11 , 15 , 27 – 31 ). The pathological diagnosis of LVI maily depends on HE staining and it can be confirmed by endothelial-associated markers, although this is not often necessary ( ).…”

Section: Discussionmentioning

confidence: 99%

“…For PCa, LVI is reported in up to 21.5% of RP specimens ( ), and the presence of LVI at time of RP is recognized as an adverse pathological feature ( 10 – 12 ). Furthermore, several studies have observed that LVI could mirror lymph node invasion status ( 13 ), and was associated with unfavorable biochemical recurrence (BCR) rates and overall survival after RP ( 11 , 12 , 14 , 15 ). The underlying mechanism of LVI remains unclear although some recent studies tried to reveal it from genetic level ( 16 – 18 ).…”

Section: Introductionmentioning

confidence: 99%

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Preoperative red cell distribution width is associated with postoperative lymphovascular invasion in prostate cancer patients treated with radical prostatectomy: A retrospective study

et al. 2022

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PurposeTo investigate the relationship between baseline clinicopathological and laboratory variables especially hematological parameters and lymphovascular invasion (LVI) in patients who underwent radical prostatectomy (RP).MethodsWe retrospectively evaluated 348 prostate cancer (PCa) patients who underwent RP in our center between May 2018 and June 2021. We divided them into non-LVI and LVI groups based on LVI status, and compared clinicopathological characteristics between non-LVI and LVI groups. Clinicopathological parameters including age, body mass index (BMI), history of hypertension and diabetes mellitus, neoadjuvant hormonal therapy (NHT), pathological stage T (pT) and lymph node status (pN), ISUP (international society of urological pathology) grade, positive surgical margin (PSM) rate, and hematological parameters containing prostate-specific antigen (PSA), whole blood parameters and inflammatory indexes were collected. The association between the clinicopathological parameters and the presence of LVI was identified by multivariate logistic regression analysis.ResultsThe pathological results of the RP specimen consisted of 53 (15.2%) patients with LVI and 295 (84.8%) cases without LVI. The level of PSA, percentages of advanced pT and grade, pN1, and PSM were significantly higher in the LVI group when compared with the non-LVI counterpart (p<0.001, p<0.001, p<0.001, p<0.001, p=0.007, respectively). Among the whole blood parameters, only red cell distribution width (RDW) was significantly different (41.2 ± 2.5 vs. 42.1 ± 3.1, p=0.035). Multivariate regression analysis demonstrated that RDW and NHT were negatively correlated with the presence of LVI (OR = 0.870, p=0.024; OR = 0.410, p=0.025), while PSA, ISUP, and pT were positively correlated with the presence of LVI (OR=1.013, p=0.005; OR =1.589, p=0.001; OR=1.655, p=0.008) after adjusting for confounding factors.ConclusionsRDW rather than other whole blood parameters was independently and negatively associated with the presence of LVI in PCa patients, suggesting that RDW might play an essential role in PCa invasion.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preoperative red cell distribution width is associated with postoperative lymphovascular invasion in prostate cancer patients treated with radical prostatectomy: A retrospective study

et al. 2022

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“…Such tumors tend to extend beyond the prostatic tissue and invade the local perineural space; this histologic finding by itself, though, does not predict positive surgical margins, extraprostatic extension, seminal vesicle invasion, or positive lymph nodes [ 3 ]. Lymphovascular invasion, however, was shown to be associated with positive surgical margins, extracapsular extension, seminal vesicle invasion, positive lymph nodes, biochemical recurrence, and decreased overall survival [ 4 ]. Metastasis occurs most commonly in regional lymph nodes and bone, followed by lung, then liver [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Overcoming Drug Resistance in Advanced Prostate Cancer by Drug Repurposing

et al. 2022

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Prostate cancer (PCa) is the second most common cancer in men. Common treatments include active surveillance, surgery, or radiation. Androgen deprivation therapy and chemotherapy are usually reserved for advanced disease or biochemical recurrence, such as castration-resistant prostate cancer (CRPC), but they are not considered curative because PCa cells eventually develop drug resistance. The latter is achieved through various cellular mechanisms that ultimately circumvent the pharmaceutical’s mode of action. The need for novel therapeutic approaches is necessary under these circumstances. An alternative way to treat PCa is by repurposing of existing drugs that were initially intended for other conditions. By extrapolating the effects of previously approved drugs to the intracellular processes of PCa, treatment options will expand. In addition, drug repurposing is cost-effective and efficient because it utilizes drugs that have already demonstrated safety and efficacy. This review catalogues the drugs that can be repurposed for PCa in preclinical studies as well as clinical trials.

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“…1 LVI represents an early step in metastasis, and in several neoplasms, such as prostate cancer, breast cancer, and MCC, LVI has been associated with lymph node (LN) positivity. [2][3][4] The prognostic utility of LVI in LN-positive MCC has not been specifically explored. In both prostate cancer and breast cancer, some evidence suggests LVI retains prognostic value even in the setting of LN metastasis and has a synergistic detrimental effect on survival in combination with regional nodal involvement.…”

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confidence: 99%

Synergistic effect of lymphovascular invasion and nodal involvement on prognosis in Merkel cell carcinoma: A retrospective analysis in the National Cancer Database

Nguyen

Maloney

Yang

et al. 2022

Journal of the American Academy of Dermatology

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Evaluation of lymphovascular invasion as a prognostic predictor of overall survival after radical prostatectomy

Cited by 6 publications

References 27 publications

Preoperative red cell distribution width is associated with postoperative lymphovascular invasion in prostate cancer patients treated with radical prostatectomy: A retrospective study

Preoperative red cell distribution width is associated with postoperative lymphovascular invasion in prostate cancer patients treated with radical prostatectomy: A retrospective study

Overcoming Drug Resistance in Advanced Prostate Cancer by Drug Repurposing

Synergistic effect of lymphovascular invasion and nodal involvement on prognosis in Merkel cell carcinoma: A retrospective analysis in the National Cancer Database

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