Abstract:Tc-99m DTPA pulmonary clearance is markedly accelerated in the volatile substance abuse. This suggests that inhalant abuse of substance may produce abnormalities in pulmonary alveolo-capillary membrane function.
“…In 2011, Cayir et al . [15] observed that the abuse of volatile drugs increased clearance of 99m Tc-DTPA aerosols, indicating increased pulmonary capillary permeability and damage to the pulmonary capillary endothelium. In 2018, Schniering et al .…”
Section: Discussionmentioning
confidence: 99%
“…In 2006, Ozşahin et al [14] used a 99m Tc-diethyltriaminepentaacetic acid (DTPA) aerosol scintillation imaging device to observe the permeability of the alveolar basement membrane in patients with type 2 diabetes, whereby increased permeability indicates alveolar basement membrane damage. In 2011, Cayir et al [15] observed that the abuse of volatile drugs increased clearance of 99m Tc-DTPA aerosols, indicating increased pulmonary capillary permeability and damage to the pulmonary capillary endothelium. In 2018, Schniering et al [16] used 177 Lu and 44 Sc to label plasma protein-binding ligands capable of binding albumin (DOTA-PPB-01) and transthyretin (DOTA-PPB-03) to observe nuclear imaging and metabolic distribution.…”
Purpose
Explore the application value of pulmonary perfusion imaging and delayed imaging for evaluating pulmonary capillary permeability.
Materials and methods
After establishing a rat model of pulmonary contusion, changes in the metabolic index of technetium-99m macroaggregated albumin (99mTC-MAA) in the lungs of model rats were evaluated for two consecutive days. 99mTC-MAA metabolic indices of rat lungs with pulmonary contusion of varying severity (mild, moderate, and severe) were correlated with lung wet/dry weight ratio (W/D) and Evans blue extravasation. Finally, the method was validated in patients with pulmonary contusion and one healthy volunteer.
Results
The 99mTC-MAA metabolic index was 23.56% ± 2.44% in healthy control (HC) rat lung, 8.56% ± 3.42% immediately after lung contusion (d0), 8.35% ± 3.20% after 1 day (d1), and 17.45% ± 6.44% after 2 days (d2); indices at d0 and d1 were significantly higher than those at HC (P < 0.05). The metabolic index of 99mTC-MAA in lung had significant negative correlations with W/D (r = −0.8025; P = 0.0092) and Evans blue extravasation (r = −0.9356; P = 0.0002). Metabolic and oxygenation indices of 99mTC-MAA exhibited a significant positive linear correlation in patients with pulmonary contusion (r = 0.8925; P = 0.0416).
Conclusion
Pulmonary perfusion and delayed imaging of 99mTC-MAA have potential value for evaluating pulmonary capillary permeability.
“…In 2011, Cayir et al . [15] observed that the abuse of volatile drugs increased clearance of 99m Tc-DTPA aerosols, indicating increased pulmonary capillary permeability and damage to the pulmonary capillary endothelium. In 2018, Schniering et al .…”
Section: Discussionmentioning
confidence: 99%
“…In 2006, Ozşahin et al [14] used a 99m Tc-diethyltriaminepentaacetic acid (DTPA) aerosol scintillation imaging device to observe the permeability of the alveolar basement membrane in patients with type 2 diabetes, whereby increased permeability indicates alveolar basement membrane damage. In 2011, Cayir et al [15] observed that the abuse of volatile drugs increased clearance of 99m Tc-DTPA aerosols, indicating increased pulmonary capillary permeability and damage to the pulmonary capillary endothelium. In 2018, Schniering et al [16] used 177 Lu and 44 Sc to label plasma protein-binding ligands capable of binding albumin (DOTA-PPB-01) and transthyretin (DOTA-PPB-03) to observe nuclear imaging and metabolic distribution.…”
Purpose
Explore the application value of pulmonary perfusion imaging and delayed imaging for evaluating pulmonary capillary permeability.
Materials and methods
After establishing a rat model of pulmonary contusion, changes in the metabolic index of technetium-99m macroaggregated albumin (99mTC-MAA) in the lungs of model rats were evaluated for two consecutive days. 99mTC-MAA metabolic indices of rat lungs with pulmonary contusion of varying severity (mild, moderate, and severe) were correlated with lung wet/dry weight ratio (W/D) and Evans blue extravasation. Finally, the method was validated in patients with pulmonary contusion and one healthy volunteer.
Results
The 99mTC-MAA metabolic index was 23.56% ± 2.44% in healthy control (HC) rat lung, 8.56% ± 3.42% immediately after lung contusion (d0), 8.35% ± 3.20% after 1 day (d1), and 17.45% ± 6.44% after 2 days (d2); indices at d0 and d1 were significantly higher than those at HC (P < 0.05). The metabolic index of 99mTC-MAA in lung had significant negative correlations with W/D (r = −0.8025; P = 0.0092) and Evans blue extravasation (r = −0.9356; P = 0.0002). Metabolic and oxygenation indices of 99mTC-MAA exhibited a significant positive linear correlation in patients with pulmonary contusion (r = 0.8925; P = 0.0416).
Conclusion
Pulmonary perfusion and delayed imaging of 99mTC-MAA have potential value for evaluating pulmonary capillary permeability.
“…Einige Kohlenwasserstoffe, wie Trichlorethylen, können eine direkte chemische Pneumonitis Chemische Pneumonitis verursachen. Toluolmissbrauch wird mit einem panlobulären Emphysem und dem Goodpasture-Syndrom in Verbindung gebracht [ 47 ]. Häufigere Befunde sind entzündliche Infiltrate Entzündliches Infiltrat durch Mikroaspirationen nach Erbrechen.…”
Der Konsum inhalativer psychotroper Substanzen ist in unserer Gesellschaft weit verbreitet. Neben der Vielzahl an tabakhaltigen Rauchwaren werden E‑Zigaretten, Cannabis, Schnüffelstoffe sowie Kokain und Heroin inhalativ konsumiert. Die schädigenden pulmonalen Auswirkungen sind zwar für die meisten tabakhaltigen Rauchwaren hinreichend erforscht, für viele andere inhalativ konsumierte Substanzen mangelt es jedoch noch an wissenschaftlich fundierten Erkenntnissen. Insbesondere für die neuartigen Produkte wie E‑Zigaretten und Tabakerhitzer fehlen unabhängige standardisierte Daten, die ein suggeriertes geringeres gesundheitliches Risiko im Vergleich zu herkömmlichen Zigaretten belegen. Auch bezüglich langfristiger Folgen von Cannabiskonsum auf Lunge und Atemwege sind eindeutige Schlussfolgerungen derzeit nicht ausreichend möglich. Für den inhalativen Gebrauch von Kokain und Heroin hingegen wurden insbesondere bei ausgiebigem und chronischem Konsum erhebliche Schädigungen der Lunge belegt.
“…,
6
When inhaled, 99m Tc-DTPA particles arrive at the alveolar epithelial surface and then diffuse from the air space into the vascular space. The clearance rate of 99m Tc-DTPA is a reliable index of alveolar epithelial permeability.…”
Objective: To evaluate the effects of positive expiratory pressure (PEP) on pulmonary epithelial membrane permeability in healthy subjects. Methods: We evaluated a cohort of 30 healthy subjects (15 males and 15 females) with a mean age of 28.3 ± 5.4 years, a mean FEV 1 /FVC ratio of 0.89 ± 0.14, and a mean FEV 1 of 98.5 ± 13.1% of predicted. Subjects underwent technetium-99m-labeled diethylenetriaminepentaacetic acid ( 99m Tc-DTPA) radioaerosol inhalation lung scintigraphy in two stages: during spontaneous breathing; and while breathing through a PEP mask at one of three PEP levels-10 cmH 2 O (n = 10), 15 cmH 2 O (n = 10), and 20 cmH 2 O (n = 10). The 99mTc-DTPA was nebulized for 3 min, and its clearance was recorded by scintigraphy over a 30-min period during spontaneous breathing and over a 30-min period during breathing through a PEP mask. Results: The pulmonary clearance of 99m Tc-DTPA was significantly shorter when PEP was applied-at 10 cmH 2 O (p = 0.044), 15 cmH 2 O (p = 0.044), and 20 cmH 2 O (p = 0.004)-in comparison with that observed during spontaneous breathing. Conclusions: Our findings indicate that PEP, at the levels tested, is able to induce an increase in pulmonary epithelial membrane permeability and lung volume in healthy subjects.
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