“…Whereas HIRs are widely used, progress in computer software and hardware technology reduced the time required for MBIRs and made them recently clinically usable. Forward projected model-based Iterative Reconstruction SoluTion Low-Contrast-Dynamic (FIRST-LCD) (Canon Medical System, Tokyo, Japan) is an MBIR solution designed to provide better low-contrast detectability and may, therefore, help in detecting early ischemic changes [ 11 , 12 , 13 , 14 ]. A few studies have reported in vitro or with a small number of patients the benefit of iterative reconstructions in acute ischemic stroke (AIS) [ 11 , 12 , 13 , 14 ].…”