Evaluation of longitudinal left ventricular function in patients with coronary artery ectasia and vitamin D deficiency by 2D speckle tracking echocardiography

Aghajani, Hassan; Faal, Mohsen; Hosseinsabet, Ali

doi:10.1111/echo.13467

Cited by 7 publications

(8 citation statements)

References 42 publications

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“…сопровождался увеличением ФВ ЛЖ на 2,73% [14]. Аналогичные данные были получены в работе Aghajani H, et al (2017), где было выявлено снижение показателей функции ЛЖ по данным допплер-ЭхоКГ у пациентов с дефицитом витамина Д [15]. Следует отметить, что прирост ФВ ЛЖ в данной работе был менее выражен, относительно результатов исследования EVITA, что, возможно, связано с более тяжелой коморбидностью больных ХОБЛ.…”

Section: Discussionunclassified

The effect of native vitamin D therapy on echocardiographic parameters of patients with chronic obstructive pulmonary disease and early-stage chronic kidney disease

Болотова

Трембач

Дудникова

2020

Cardiovasc Ther Prev

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Aim. To assess the dynamics of the main echocardiographic parameters in patients with chronic obstructive pulmonary disease (COPD) and early-stage chronic kidney disease (CKD) taking native vitamin D.Material and methods. The study included 264 patients, which were divided into two groups: experimental group (n=135) — patients with stage 2-4 COPD (men, mean age — 72,2±3,8 years, mean disease duration — 23,1±3,4 years); control group (n=136) — patients with stage 2-4 COPD, comparable in age and sex. Patients of both groups were divided into 4 subgroups depending on forced expiratory volume in 1 second and vitamin D levels. In the experimental group, native vitamin D therapy was performed according to regimen that maintains its level >34,3 ng/ml during the year; in the control group — according to the Russian Association of Endocrinologists guidelines. Echocardiography was performed for all patients at the beginning and end of the study.Results. In all subgroups of the experimental group, a statistically significant increase in the left ventricular ejection fraction was revealed (p<0,05); in patients with moderate COPD (GOLD 2) and vitamin D deficiency and patients with severe and very severe COPD (GOLD 3,4) and vitamin D insufficiency of the experimental group, we observed a significant decrease in the end-systolic dimension, average left atrial size and increase in stroke volume and stroke volume index, as well as normalization of the left ventricular geometry (p<0,05). In the control group after 12 months, no significant changes were detected.Conclusion. Maintaining of vitamin D level >34,3 ng/ml for 12 months in patients with COPD and early-stage CKD was associated with a significant improvement in myocardial remodeling. This indicates an improvement in cardiovascular adaptation and function.

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Section: Discussionunclassified

The effect of native vitamin D therapy on echocardiographic parameters of patients with chronic obstructive pulmonary disease and early-stage chronic kidney disease

Болотова

Трембач

Дудникова

2020

Cardiovasc Ther Prev

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“…They also noted a negative correlation between VitD and the E/E' ratio, a LV filling pressure marker. 23 Recently, Aghajani et al, 24 evaluated the longitudinal left ventricular function in patients with coronary artery ectasia (CAE) and vitamin D deficiency by echocardiography. The results showed that LV systolic and diastolic function in patients with CAE and Vitamin D deficiency were impaired.…”

Section: Discussionmentioning

confidence: 99%

“…The results showed that LV systolic and diastolic function in patients with CAE and Vitamin D deficiency were impaired. 24 Another study on supplementation showed that D-deficient prediabetic African American males who were treated with highdose vitamin D2 were found to have attenuated increases in left atrial volume compared with controls over 12-month follow-up. 25 Our findings are in line with what is described in the literature.…”

Section: Discussionmentioning

confidence: 99%

Increased Left Atrial Volume and Its Relationship to Vitamin D in Primary Care

Macedo

Rosa

Jorge

et al. 2019

International Journal of Cardiovascular Sciences

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Background:The study is based on the fact that left atrial (LA) volume measurement is a marker of the presence of diastolic dysfunction and that Vitamin D deficiency may be associated with ventricular remodeling, worsening of left ventricular (LV) diastolic and systolic function, and activation of the renin-angiotensinaldosterone system.Objective: To evaluate whether LAV changes are related to vitamin D deficiency. Method:A cross-sectional, population-based, unicentric study in which 640 patients over 45 years of age enrolled in the Niterói's Médico de Família program, RJ, were evaluated. Patients were submitted to tissue Doppler echocardiography to evaluate the parameters of diastolic and systolic function and vitamin D dosage. The presence or absence of hypovitaminosis D associated with structural and functional cardiac changes was compared between each group. A p < 0.05 value was considered as an indicator of statistical significance.Results: Of the 640 individuals analyzed, hypovitaminosis D was confirmed in 39.2% of the patients, of whom 34.8% had diastolic dysfunction. The most relevant echocardiographic parameters that were statistically significant were non-indexed AEDs and LAV, E'/A' and E wave deceleration time, which were associated with the presence of hypovitaminosis D (P < 0.01). Conclusion:The study of the association of hypovitaminosis D and the appearance of structural and functional cardiac abnormalities may contribute to the discussion of the adoption of one more criterion to select individuals at risk of developing clinical cardiac insufficiency in primary care since, with the use of echocardiography, the subclinical condition of cardiac involvement, with prognostic and treatment implications for the referred patients with hypovitaminosis D, can be identified early.

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“…More than 80% of CAE patients experience coronary artery disease (CAD) (1,3); their main symptoms include angina, myocardial infarction, arrhythmia, and sudden death, and most are treated under the principle of current guidelines for CAD (4,5). However, CAE is also characterized by obvious slow blood flow in dilated coronary arteries (6,7), increased inflammatory markers in peripheral blood (8), anomalies in other blood vessels (9)(10)(11), and decreased left ventricular diastolic function (12). Pathologically, CAE is characterized by the extensive destruction of the musculoelastic elements in the coronary wall (3,4).…”

Section: Introductionmentioning

confidence: 99%

Is Coronary Artery Ectasia a Progressive Disease? A Self-Controlled Retrospective Cohort Study

Liu

Zhao

Gao

et al. 2021

Front. Cardiovasc. Med.

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Objective: It is essential to understand whether coronary artery ectasia (CAE) progresses over time because the patients might be under the risk of coronary rupture, and stent implant should be avoided if ectatic changes progress.Methods: A consecutive series of 99 CAE patients who had undergone coronary angiography at least twice were enrolled and followed up for 1–16 years until they received a second angiogram. Subjects were divided into two groups (1–5 vs. 5–16 years of follow-up), then the basic clinical characteristics and coronary artery images were compared over time.Results: (1) All CAE patients exhibited atherosclerosis, and a majority presented with acute myocardial infarction. Most baseline clinical characteristics were relatively stable. (2) Atherosclerosis (indicated by the distribution of stenosis in coronary vessels) and the Gensini scores progressed significantly. Ectasia extent showed minimal changes as indicated by blood vessel involvement, Markis type, coronary blood flow, ectasia diameter, and ectasia length. (3) Multilinear regression analysis revealed that the underlying factors related to stenosis evolution indicated by fold of Gensini score were: longer time interval, lower baseline Gensini score, and higher hypersensitive C-reactive protein concentration. (4) There was a relationship between the ectatic diameter and the extent of stenosis.Conclusions: For CAE patients with atherosclerosis followed for 1–16 years, there was minimal CAE progression, while the atherosclerosis progressed and the ectasia extent was related to degree of stenosis. The results indicate that prevention and treatment of atherosclerotic changes might have more clinical significance than addressing ectatic changes.

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Evaluation of longitudinal left ventricular function in patients with coronary artery ectasia and vitamin D deficiency by 2D speckle tracking echocardiography

Abstract: The systolic and diastolic functions of the LV in the patients with CAE and vitamin D deficiency were impaired as evaluated by 2DSTE.

Cited by 7 publications

References 42 publications

The effect of native vitamin D therapy on echocardiographic parameters of patients with chronic obstructive pulmonary disease and early-stage chronic kidney disease

The effect of native vitamin D therapy on echocardiographic parameters of patients with chronic obstructive pulmonary disease and early-stage chronic kidney disease

Increased Left Atrial Volume and Its Relationship to Vitamin D in Primary Care

Is Coronary Artery Ectasia a Progressive Disease? A Self-Controlled Retrospective Cohort Study

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