Evaluation of long-term sequelae by cardiopulmonary exercise testing 12 months after hospitalization for critical COVID-19

Noureddine, S.; Roux, Pauline; Laurent, Lucie; Ritter, Ophélie; Dolla, Pauline; Karaer, Sinan; Claudé, F; Westeel, Virginie; Barnig, C.

doi:10.1101/2022.09.12.22279779

Cited by 5 publications

(4 citation statements)

References 38 publications

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“…A French study carried out a cardiopulmonary test 12 months after hospitalization for COVID-19 (23) and found VȮ 2 values within normal limits in 80% of their sample, but reported ventilatory ine ciency, which corroborates the behavior of V̇E throughout the period, similarly to our study.…”

Section: Figure 1 Heresupporting

confidence: 89%

“…However, there remains a dearth of evidence concerning the assessment of functional capacity using eld tests combined with gas analysis in this population. Furthermore, most studies examining long COVID have focused on evaluating patients up to 6 months (20,21) and 12 months post-infection (22,23) following the acute phase. Few studies have ventured into assessing the functional capacity and QoL in this population beyond the two-year mark since the onset of the acute disease.…”

Section: Figure 1 Herementioning

confidence: 99%

“…A French study conducted a cardiopulmonary test 12 months following hospitalization for COVID-19 (23).…”

Section: Figure 1 Herementioning

confidence: 99%

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Exercise Intolerance in Long Covid After 24 Months From Severe Acute Disease: is There Room for Improvement?

Borges,

Braga,

Viana

et al. 2024

Preprint

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Introduction: Long COVID is a complex and multisystemic condition, where dyspnea, fatigue, post-exertional malaise, cognitive impairment, decreased functional capacity, and deterioration in quality of life are the most incident clinical features. Few studies have reported cardiopulmonary alterations 24 months after severe COVID-19 infection. Objective: to evaluate the functional capacity of individuals with persistent symptoms after severe COVID-19 infection compared to control individuals without symptomatic COVID or mild COVID after 24 months. Methods: This is a case-control study assessing 34 individuals divided into 2 groups (severe COVID-19 with long COVID and a control group consisting of asymptomatic/mild acute COVID-19 with no long COVID) regarding functional capacity by 6-minute walk test (6MWT) associated with gas analysis, spirometry, respiratory muscle strength and quality of life. Results: During the 6MWT, an important lower heart rate (HR) was observed for the COVID group, with greater exertional perception, a significant decrease in the distance covered, and a low value of O2 uptake (V̇O2) and minute ventilation, in addition to very low quality of life scores, especially in aspects of functional capacity and physical limitations. Conclusion: individuals who have severe COVID-19 and persist with symptoms have low functional capacity, low V̇O2, low HR behavior, and low quality of life.

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Section: Figure 1 Heresupporting

confidence: 89%

Section: Figure 1 Herementioning

confidence: 99%

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Exercise Intolerance in Long Covid After 24 Months From Severe Acute Disease: is There Room for Improvement?

Borges,

Braga,

Viana

et al. 2024

Preprint

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“…Interestingly, studies have reported persistent pulmonary symptoms in patients without persistent physiologic impairments [39,40]. One study aimed to investigate the long-term pulmonary effects of severe COVID-19 pneumonia by assessing cardiopulmonary exercise test (CPET) performance in 60 patients 12 months after a COVID-19 infection that required ICU management [41]. Exercise capacity assessed by CPET was within normal limits in most patients 12 months after hospitalization, and impairment was predominantly related to persistent deconditioning or prior respiratory comorbidities.…”

Section: Plos Onementioning

confidence: 99%

Healthcare utilization 9 months pre- and post- COVID-19 hospitalization among patients discharged alive

Zaidan,

Puebla Neira,

Polychronopoulou

et al. 2024

PLoS ONE

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Background Emerging evidence suggests that there is an increase in healthcare utilization (HCU) in patients due to Coronavirus Disease 2019 (COVID-19). We investigated the change in HCU pre and post hospitalization among patients discharged home from COVID-19 hospitalization for up to 9 months of follow up. Study design and methods This retrospective study from a United States cohort used Optum® de-identified Clinformatics Data Mart; it included adults discharged home post hospitalization with primary diagnosis of COVID-19 between April 2020 and March 2021. We evaluated HCU of patients 9 months pre and post -discharge from index hospitalization. We defined HCU as emergency department (ED), inpatient, outpatient (office), rehabilitation/skilled nursing facility (SNF), telemedicine visits, and length of stay, expressed as number of visits per 10,000 person-days. Results We identified 63,161 patients discharged home after COVID-19 hospitalization. The cohort of patients was mostly white (58.8%) and women (53.7%), with mean age 72.4 (SD± 12) years. These patients were significantly more likely to have increased HCU in the 9 months post hospitalization compared to the 9 months prior. Patients had a 47%, 67%, 65%, and 51% increased risk of ED (rate ratio 1.47; 95% CI 1.45–1.49; p < .0001), rehabilitation (rate ratio 1.67; 95% CI 1.61–1.73; p < .0001), office (rate ratio1.65; 95% CI 1.64–1.65; p < .0001), and telemedicine visits (rate ratio 1.5; 95% CI 1.48–1.54; p < .0001), respectively. We also found significantly different rates of HCU for women compared to men (women have higher risk of ED, rehabilitation, and telemedicine visits but a lower risk of inpatient visits, length of stay, and office visits than men) and for patients who received care in the intensive care unit (ICU) vs those who did not (ICU patients had increased risk of ED, inpatient, office, and telemedicine visits and longer length of stay but a lower risk of rehabilitation visits). Outpatient (office) visits were the highest healthcare service utilized post discharge (64.5% increase). Finally, the risk of having an outpatient visit to any of the specialties studied significantly increased post discharge. Interestingly, the risk of requiring a visit to pulmonary medicine was the highest amongst the specialties studied (rate ratio 3.35, 95% CI 3.26–3.45, p < .0001). Conclusion HCU was higher after index hospitalization compared to 9 months prior among patients discharged home post-COVID-19 hospitalization. The increases in HCU may be driven by those patients who received care in the ICU.

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Optimizing cardiopulmonary rehabilitation duration for long COVID patients: an exercise physiology monitoring approach

Szarvas,

Fekete,

Szollosi

et al. 2024

GeroScience

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The presence of prolonged symptoms after COVID infection worsens the workability and quality of life. 200 adults with long COVID syndrome were enrolled after medical, physical, and mental screening, and were divided into two groups based on their performance. The intervention group (n = 100) received supervised rehabilitation at Department of Pulmonology, Semmelweis University with the registration number 160/2021 between 01/APR/2021–31/DEC/2022, while an age-matched control group (n = 100) received a single check-up. To evaluate the long-term effects of the rehabilitation, the intervention group was involved in a 2- and 3-month follow-up, carrying out cardiopulmonary exercise test. Our study contributes understanding long COVID rehabilitation, emphasizing the potential benefits of structured cardiopulmonary rehabilitation in enhancing patient outcomes and well-being. Significant difference was found between intervention group and control group at baseline visit in pulmonary parameters, as forced vital capacity, forced expiratory volume, forced expiratory volume, transfer factor for carbon monoxide, transfer coefficient for carbon monoxide, and oxygen saturation (all p < 0.05). Our follow-up study proved that a 2-week long, patient-centered pulmonary rehabilitation program has a positive long-term effect on people with symptomatic long COVID syndrome. Our data showed significant improvement between two and three months in maximal oxygen consumption (p < 0.05). Multidisciplinary, individualized approach may be a key element of a successful cardiopulmonary rehabilitation in long COVID conditions, which improves workload, quality of life, respiratory function, and status of patients with long COVID syndrome.

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Evaluation of long-term sequelae by cardiopulmonary exercise testing 12 months after hospitalization for critical COVID-19

Cited by 5 publications

References 38 publications

Exercise Intolerance in Long Covid After 24 Months From Severe Acute Disease: is There Room for Improvement?

Exercise Intolerance in Long Covid After 24 Months From Severe Acute Disease: is There Room for Improvement?

Healthcare utilization 9 months pre- and post- COVID-19 hospitalization among patients discharged alive

Optimizing cardiopulmonary rehabilitation duration for long COVID patients: an exercise physiology monitoring approach

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