Evaluation of Long Term Prognosis in Patients Treated with Narrowband Ultraviolet B: A Retrospective Study for 8 Years

Akay, Gül Aslıhan Çakir; Yıldırım, Dilsun; Kar, İrem

doi:10.5336/medsci.2019-66821

Cited by 1 publication

(1 citation statement)

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“…(2016) 24 . In this Spanish consensus initiative, a target of “prolonged remissions without loss of efficacy” was recommended as an ideal treatment goal, yet a definition of remission was not provided 23 . Carretero et al .…”

Section: Resultsmentioning

confidence: 99%

Definitions of remission in psoriasis: a systematic literature review from the National Psoriasis Foundation

Balak

Pérez-Chada

Guo

et al. 2022

Acad Dermatol Venereol

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Psoriasis studies increasingly employ outcomes that indicate complete disease resolution, yet remission and cure are poorly defined for psoriasis. We conducted a systematic literature review to identify definitions of psoriasis remission and cure reported in the literature. Medline, EMBASE, and The Cochrane Central Register of Controlled Trials databases were searched on July 22, 2020, for full-text studies providing definitions for psoriasis remission/cure. Definitions were analysed descriptively for endpoint, time-frame, on/off treatment, patient-reported outcomes, and disease domains. We identified 106 studies that provided 41 unique remission definitions. Most definitions included endpoints based on Psoriasis Area and Severity Index (PASI), such as PASI75 (n = 16 studies), PASI90 (n = 10), PASI100 (n = 10), and PASI of 0 (n = 3), and descriptive endpoints related to 'skin clearance' (n = 18). Few definitions specified time-frame, on/off treatment or other psoriasis-related disease domains. One small consensus-initiative defined drug-free remission for plaque psoriasis by BSA of 0 without any therapy for at least 12 months. While there is no cure for psoriasis, seven studies defined psoriasis cure using similar endpoints to those used to define remission. We identified a variety of definitions of psoriasis remission. These results will inform the development of consensus-based definitions for psoriasis remission to support efforts to improve research and clinical outcomes.

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Section: Resultsmentioning

confidence: 99%