Evaluation of long-term outcomes of pasteurized autografts in limb salvage surgeries for bone and soft tissue sarcomas

Abstract

Our findings show that pasteurized bone grafts in combination with vascularized fibular grafts have improved outcomes and potential clinical indications.

Pasteurized autograft reconstruction after resection of periacetabular malignant bone tumours

“…Pasteurization is an alternative method to tumour-bearing bone treatment for reconstruction after the resection of a malignant bone tumour [24–26, 29–31]. In the current study, we used pasteurized autografts to reconstruct the pelvis after periacetabular malignant bone tumour resection; the mean MSTS score for patients with autograft and prosthesis in situ was 75.0% (range 60–86.6%) which was comparable to other reports (Table 2).…”

“…Pasteurization of the autograft is sufficient for killing all the tumour cells in the massive bone [29, 30, 32]. Local recurrence rates with pasteurized autograft use were not significantly different compared with prosthesis [26] and allograft [31].…”

“…Compared with autoclaving, pasteurization of autograft does not only eliminate malignant cells but also preserves the osteo-inductive activity of the human bone morphogenetic protein [29, 30, 32]. In the current study, if the anterior superior iliac spine was not invaded by tumour, we osteotomized it with the sartorius muscle and fixed it to the pasteurized autograft with a screw.…”

Bone Reconstruction: Structural Allograft and Autograft

“…재활용 동소 자가골 이식술(recycled orthotopic autograft) [57][58][59][60][61][62] 재활용 동소 자가골 이식술은 광범위 절제한 종양 조직을 고온-고압 처리(autoclaved graft), 저온 열처리(pasteurized graft), 59,60,63,64) 방사선 조사(irradiated graft), 57,65,66) …”

Tissue Engineering: Alternative Option in Managing Large and Massive Tissue Deficits

“…There are many different conditions that make a tissue loss including massive traumatic injuries, cancers, and degenerative diseases. Tropical diseases could also be considered as the risk factors of inducing large tissue losses [1][2][3]. Some physiological conditions such as aging, obesity and repeated pregnancies are also other predisposing items which facilitate injury induction and may result in tissue losses [4].…”