Evaluation of Liver Steatotic and Fibrous Content by Computerized Tomography and Ultrasound

Pamilo, M.; Ea, Sotaniemi; Suramo, I; Lähde, S; Aj, Arranto

doi:10.3109/00365528309182089

Cited by 55 publications

(30 citation statements)

References 16 publications

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“…Some of the investigated imaging tests include ultrasound, CT, and MR studies. [28][29][30] In this study, patients underwent either CT or MRI as part of their evaluation. In our experience, when imaging detected the presence of fat, it was present on biopsy in all cases.…”

Section: Discussionmentioning

confidence: 99%

Body mass index as a predictor of hepatic steatosis in living liver donors

Rinella

Alonso

Rao

et al. 2001

Liver Transplantation

238

182

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Evaluation of the living donor for liver transplantation is a complex process involving such invasive studies as liver biopsy and angiography. It is important to establish the likelihood and extent of hepatic steatosis in living donors by clinical, imaging, and biochemical parameters to avoid performing a liver biopsy, if possible. In this study, the predictive value of body mass index (BMI), liver chemistry tests, and imaging studies was compared with liver histological examination in 33 potential living donors. Patients were grouped and compared based on their BMI (<25, 25 to 28, >28). No patient with a BMI less than 25 had hepatic steatosis. Of patients with a BMI of 25 to 28, steatosis was found on biopsy in 3 of 9 patients. Thirteen of 17 patients (76%) with a BMI greater than 28 had hepatic steatosis on liver biopsy. There was a significant correlation between BMI and overall grade of steatosis (R ‫؍‬ 0.49). All subjects with steatosis detected on magnetic resonance imaging (MRI) or computed tomography (CT) had steatosis on biopsy, and all but 2 such patients had greater than 10% steatosis on biopsy. Conversely, 30% of patients in the MRI group and 24% of patients in the CT group failed to show hepatic steatosis when it was present on biopsy. Thus, it appears that liver biopsy could be avoided in subjects with a normal BMI and absence of risk factors. Individuals with a high BMI should undergo liver biopsy because biochemical and imaging data are currently inadequate to determine the extent of steatosis. Future studies should aim at improving the sensitivity of imaging techniques in the diagnosis of steatosis. (Liver Transpl 2001;7:409-414.)

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Section: Discussionmentioning

confidence: 99%

Body mass index as a predictor of hepatic steatosis in living liver donors

Rinella

Alonso

Rao

et al. 2001

Liver Transplantation

238

182

View full text Add to dashboard Cite

show abstract

“…Since the introduction of computed tomography (CT) in the 1970s, the use of CT in diagnosis of hepatic steatosis has been evaluated by various investigators [64][65][66]. CT provides an accurate and a reliable visualization of the whole liver, so that not only diffuse but also focal fatty infiltrations of the liver parenchyma can be accurately diagnosed.…”

Section: Computed Tomographymentioning

confidence: 99%

Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance

Schwenzer

Springer

Schraml

et al. 2009

Journal of Hepatology

683

562

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“…6 The ability of various imaging techniques to detect the presence of steatosis is well established; nevertheless, none have been able to accurately quantify the degree of steatosis in this population. [7][8][9] Therefore, an accurate noninvasive method of quantifying hepatic steatosis remains unavailable. In a recent article, the threshold for the detection of steatosis in patients with nonalcoholic fatty liver disease (NAFLD) using computed tomography (CT) or ultrasound was 33%.…”

mentioning

confidence: 99%

Dual-echo, chemical shift gradient-echo magnetic resonance imaging to quantify hepatic steatosis: Implications for living liver donation

Rinella

McCarthy

Thakrar

et al. 2003

Liver Transplantation

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In living liver donation, a fatty liver poses risks for both recipient and donor. Currently, liver biopsy is the standard for assessing the presence and extent of steatosis. The goals of this study were to correlate a steatosis index derived from magnetic resonance imaging (MRI) to the histologic grade on biopsy as well as to determine the topographic distribution of steatosis within the liver. We examined the ability of dual-echo, chemical shift gradientecho MRI to predict the degree of steatosis on liver biopsy. A total of 22 subjects received both a liver biopsy and detailed MRI evaluation. These individuals included 15 potential living donors and 7 patients with nonalcoholic fatty liver disease. MRI steatosis index was then compared with histologic grade on liver biopsy. The topographic distribution of hepatic steatosis was determined from those subjects in whom MRI detected hepatic steatosis.

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Evaluation of Liver Steatotic and Fibrous Content by Computerized Tomography and Ultrasound

Cited by 55 publications

References 16 publications

Body mass index as a predictor of hepatic steatosis in living liver donors

Body mass index as a predictor of hepatic steatosis in living liver donors

Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance

Dual-echo, chemical shift gradient-echo magnetic resonance imaging to quantify hepatic steatosis: Implications for living liver donation

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