Evaluation of Liver, Kidney, and Spleen Elasticity in Healthy Newborns and Infants Using Shear Wave Elastography

Palabıyık, Figen; İnci, Ercan; Türkay, Rüştü; Bas, Derya

doi:10.1002/jum.14202

Cited by 20 publications

(16 citation statements)

References 23 publications

(54 reference statements)

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“…In the present study, we could not make comparisons regarding the accuracy of predicting HR‐EGV between 2D‐SWE and TE. However, 2D‐SWE measurements of the spleen were also reportedly measurable in healthy infants and the present study was able to measure SS by 2D‐SWE in all children. Spleen stiffness was found to be more accurate than LS as a predictor of HR‐EGV.…”

Section: Discussionmentioning

confidence: 52%

Spleen stiffness by 2‐D shear wave elastography is the most accurate predictor of high‐risk esophagogastric varices in children with biliary atresia

Yokoyama¹,

Ishigami²,

Honda³

et al. 2019

Hepatology Research

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Aim Esophagogastric variceal hemorrhage is a cause of poor prognosis in patients with biliary atresia (BA). To prevent variceal hemorrhage, simple and reliable screening methods for high‐risk esophagogastric varices (HR‐EGV) are needed. We evaluated the efficacy of liver stiffness (LS) and spleen stiffness (SS) as measured by 2‐D shear wave elastography (2D‐SWE), which was reported to be more accurate than transient elastography, for detecting HR‐EGV in children with BA. Methods Thirty‐four children with BA were enrolled. Both LS and SS were measured by 2D‐SWE. The presence of large esophageal varices or esophageal varices of any size with red wale marking and/or the presence of gastric varices along the cardia were defined as HR‐EGV. Clinical data were collected and previously reported prediction indices for varices were calculated. Results Liver stiffness and SS were obtained from all patients. Fourteen patients showed HR‐EGV. Significantly different variables between patients with and without HR‐EGV were as follows: spleen diameter (116 mm vs. 95 mm), clinical prediction rule (104.7 vs. 124.7), King's variceal prediction score (78.8 vs. 99.4), aspartic aminotransferase‐to‐platelet ratio index (2.03 vs. 0.98), LS (2.63 m/s vs. 1.87 m/s), and SS (4.44 m/s vs. 3.69 m/s). The highest area under the receiver operating characteristic curve for detecting HR‐EGV was that for SS (0.900), and the cut‐off SS of 4.12 m/s yielded 92.9% sensitivity and 90% specificity. The intraclass correlation coefficient for intra‐observer reproducibility was 0.828. Conclusions Spleen stiffness from 2D‐SWE offered the most accurate predictor of HR‐EGV in BA children.

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Section: Discussionmentioning

confidence: 52%

Spleen stiffness by 2‐D shear wave elastography is the most accurate predictor of high‐risk esophagogastric varices in children with biliary atresia

Yokoyama¹,

Ishigami²,

Honda³

et al. 2019

Hepatology Research

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“…The blank spaces represent a lack of information. References for brain (Gunawan et al, 2015;Kaster et al, 2011;Law et al, 1985;Liu et al, 2017;Morin et al, 2017;Pinton et al, 2011) for liver Civale et al, 2013;Degos et al, 2010;Freese & Lyons, 1977;Ito et al, 2017;Law et al, 1985;Liu et al, 2006;Palabiyik et al, 2017;Tzschatzsch et al, 2016;Wear et al, 1995) and for kidney (Gennisson et al, 2012;Grenier, Gennisson et al, 2013;Insana et al, 1992;Palabiyik et al, 2017) 2-6, 2-7, 2-8, and 2-9. .............................................................................................53 Table 2-7.…”

Section: List Of Figuresmentioning

confidence: 99%

The acoustical properties of IEC agar-based tissue mimicking material over the frequency range 4.5MHz to 50MHz - a longitudinal study

Rabell-Montiel

Pye

Anderson

et al. 2016

2016 IEEE International Ultrasonics Symposium (IUS)

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Commercially available ultrasound quality assurance test phantoms rely on the long-term acoustic stability of the tissue-mimicking-material (TMM). Measurement of the acoustic properties of the TMM can be technically challenging, and it is important to ensure its stability. The standard technique is to film-wrap samples of TMM and to measure the acoustic properties in a water bath. In this study, a modified technique was proposed whereby the samples of TMM are measured in a preserving fluid that is intended to maintain their characteristics. The acoustic properties were evaluated using a broadband pulse-echo substitution technique over the frequency range 4.5-50 MHz at 0, 6 and 12 months using both techniques. For both techniques, the measured mean values for the speed of sound and attenuation were very similar and within the International Electrotechnical Commission-recommended value. However, the results obtained using the proposed modified technique exhibited greater stability over the 1-y period compared with the results acquired using the standard technique.

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“…In SWE, the newest of these methods, the liver stiffness is estimated by measuring the propagation velocity of shear wave in tissues, and the two‐dimensional ultrasound technique is used for real‐time comparison. It has the advantages of having good reproducibility, high spatial resolution and being a quantitative evaluation that is not affected by compression artifacts . TE has some limitations in young children; some authors reported technical failure in 17% of children younger than 2 years old, and others reported technical failure in 10% of children of any age .…”

Section: Introductionmentioning

confidence: 99%

“…It has the advantages of having good reproducibility, high spatial resolution and being a quantitative evaluation that is not affected by compression artifacts. 5 TE has some limitations in young children; some authors reported technical failure in 17% of children younger than 2 years old, and others reported technical failure in 10% of children of any age. 6 SWE is a noninvasive imaging technique that shows promising reliability and clinical utility for the quantitative assessment of liver tissue stiffness, particularly in children.…”

Section: Introductionmentioning

confidence: 99%

Shear‐wave elastography of the liver in a healthy pediatric population

Yang

Sun

Tang

et al. 2019

J of Clinical Ultrasound

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Purpose The aim of this study was to determine the elastic modulus values of normal liver tissue in school‐age children by shear wave elastography (SWE) and to study the factors that influence these stiffness measurements. Methods Six hundred and four school‐age children (295 girls and 309 boys) who were recruited at a hospital and had normal results of specific laboratory tests and imaging studies underwent SWE examinations. The elastic modulus values were obtained in segment V and VI for each subject and comparisons were made between age groups. Results The mean elastic modulus values for school‐age children were 6.3 ± 1.1 kPa for segment V and 6.2 ± 1.1 kPa for segment VI. A positive linear trend in liver stiffness was found for the 6 to 9‐year‐old age group in segments V and VI (R2 = 0.076 vs R2 = 0.085, respectively, P < .05). No statistically significant difference in liver stiffness was found between genders and between segment groups (P > .05). Conclusion SWE is a feasible method to measure liver stiffness in the school‐age population. We established a normal range of liver elastic modulus values in school‐age children, which will provide a basis for evaluating the changes in liver stiffness caused by various diseases.

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Evaluation of Liver, Kidney, and Spleen Elasticity in Healthy Newborns and Infants Using Shear Wave Elastography

Cited by 20 publications

References 23 publications

Spleen stiffness by 2‐D shear wave elastography is the most accurate predictor of high‐risk esophagogastric varices in children with biliary atresia

Spleen stiffness by 2‐D shear wave elastography is the most accurate predictor of high‐risk esophagogastric varices in children with biliary atresia

The acoustical properties of IEC agar-based tissue mimicking material over the frequency range 4.5MHz to 50MHz - a longitudinal study

Shear‐wave elastography of the liver in a healthy pediatric population

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