Evaluation of liver function tests of HIV positive patients on Antiretroviral Therapy in Nnewi,Nigeria.

Analike, RA; Nnamah, NK; Dioka, CE; Meludu, SC; Osuji, CU; Asomugha, AL

doi:10.4314/jbi.v4i2.30415

Cited by 3 publications

(6 citation statements)

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“…Also, the mean CD4 count of the control subjects is significantly increased as compared with that of the other two groups. This is in agreement with a former study that reported lowered mean CD4 counts in HIV positive individuals [6].…”

Section: Discussionsupporting

confidence: 94%

“…The authors of an earlier study, conducted in Orlu, Nigeria, reported increased levels of liver enzymes alanine and aspartate aminotransferase (ALT and AST) and lowered mean CD4 counts among HIV positive individuals [5]. Another research on liver function of HIV positive patients receiving antiretroviral therapy (ART) revealed increase in the activities of ALT, AST and alkaline phosphatase (ALP) of HIV positive patients [6]. In Cameroon, increases in blood transaminases levels after highly active ART (HAART) initiation was reported with a conclusion that HAART is associated with low level hepatotoxicity [7].…”

Section: Introductionmentioning

confidence: 99%

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Patterns of CD4+ T-lymphocytes and liver enzymes in adult HIV seropositive cases

Usman¹,

Agboola²,

Akintayo-Usman³

et al. 2015

J Exp Integr Med

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Objectives: HIV/AIDS is a rapidly growing epidemic in sub-Saharan Africa. HIV is a retrovirus that primarily infects components of the human immune system such as CD4+ T-cells, macrophages and dendritic cells. This study is therefore designed to evaluate the CD4+ T-cell count and liver enzymes of adult HIV seropositive subjects receiving Highly Active Antiretroviral Therapy (HAART) and those yet to be started on HAART as well as HIV seronegative control subjects. Methods: Serum levels of CD4+ counts of subjects were determined using flow cytometry while their serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were determined using enzymatic spectrophotometric method. Results: Serum ALT was found to be significantly increased in the HAART group as compared with those of the two other groups. In addition, serum ALP was significantly increased in the HAART group as compared with the control subjects, while serum AST was higher in the HAART group as compared with the HAART naive group. Conclusion: HAART is associated with hepatotoxicity, thus, it is recommended that liver enzymes should be measured before and periodically after antiretroviral therapy is initiated and/or when HAART regimen is switched, as this will serve a good index for disease monitoring and/or progression.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Patterns of CD4+ T-lymphocytes and liver enzymes in adult HIV seropositive cases

Usman¹,

Agboola²,

Akintayo-Usman³

et al. 2015

J Exp Integr Med

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show abstract

“…31 Increased liver enzymes signify poor nutritional status associated with a high consumption of maize meal and lower consumption of meat and vegetables which results in an inadequate intake of nutrients and poor nutritional status. 34 High levels of AST have been reported in HIV positive patients not on ART therapy 43 however it has also been reported with protein-energy malnutrition, 44 where levels increase according to the severity. The single most important factor that leads to malnourishment is poverty.…”

Section: Discussionmentioning

confidence: 98%

Increased risk of mortality and loss to follow-up among HIV-positive patients with oropharyngeal candidiasis and malnutrition before antiretroviral therapy initiation: a retrospective analysis from a large urban cohort in Johannesburg, South Africa

Evans

Maskew

Sanne

2012

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Objective We investigated the effect of oropharyngeal candidiasis (OC) and body mass index (BMI) prior to ART initiation on treatment outcomes of HIV-positive patients. Methods Treatment outcomes included failure to increase CD4 count by ≥50 or ≥100cells/mm3 or failure to suppress viral load (<400copies/ml) at 6- or 12-months in addition to loss to follow-up (LTFU) and mortality by 12-months. Risk and hazard ratios were estimated using log-binomial regression and Cox proportional hazards models, respectively. Results Baseline CD4 <100cells/mm3, low BMI (<18.5 kg/m2), low hemoglobin and elevated aspartate transaminase were associated with OC at ART initiation. Patients with low BMI with/without OC were at risk of mortality (Hazard Ratio (HR)2.42 95%CI 1.88–3.12; HR1.87 95% CI 1.54-2.28) and LTFU (HR1.36 95%CI 1.02–1.82; HR1.55 95% CI 1.30-1.85). Conclusion Low BMI (with/without OC) at ART initiation was associated with poor treatment outcomes. Conversely, normal BMI with OC was associated with adequate CD4 response and reduced LTFU compared to without OC.

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“…Although the changes in biochemical parameters, other than transferases, in this study were within the normal levels, significant changes in creatinine, sodium, potassium and conjugated bilirubin concentrations have been reported among HIV/AIDS patients in earlier studies [4,[18][19][20]. In earlier studies in Nigeria, increase in creatinine concentration, total and conjugated bilirubin as well as mild hyponatraemia and hypokalaemia were reported in some patients on HAART [4,19].…”

Section: Discussionmentioning

confidence: 42%

“…In earlier studies in Nigeria, increase in creatinine concentration, total and conjugated bilirubin as well as mild hyponatraemia and hypokalaemia were reported in some patients on HAART [4,19]. On the contrary, decrease in levels of creatinine and urea was also reported [18,20].…”

Section: Discussionmentioning

confidence: 99%

Long-term effect of Haart on biochemical profiles of HIV/AIDS patients in a tertiary health facility in Benin city, Nigeria

Bello¹,

Onunu²,

Erah

2014

Trop. J. Pharm Res

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Purpose: To assess the long-term effect of highly active antiretroviral therapy (HAART) on biochemical parameters of HIV-infected patients in University of (137.5 ± 5.1, 3.9 ± 0.5, 104.3 ± 5.7 mmol/l respectively, p < 0.001). Also, levels of creatinine (0.8 ± 0.2 mg/dl), TBil (0.5 ± 0.2 mg/dl), and CB (0.3 ± 0.5 mg/dl) were significantly higher in patients on HAART than those of either the positive (0.7 ± 0.3, 0.4 ± 0.2, 0.2 ± 0.1 mg/dl) or negative (0.7 ± 0.3, 0.3 ± 0.1, 0.2 ± 0.1 mg/dl)

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Evaluation of liver function tests of HIV positive patients on Antiretroviral Therapy in Nnewi,Nigeria.

Cited by 3 publications

References 0 publications

Patterns of CD4+ T-lymphocytes and liver enzymes in adult HIV seropositive cases

Patterns of CD4+ T-lymphocytes and liver enzymes in adult HIV seropositive cases

Increased risk of mortality and loss to follow-up among HIV-positive patients with oropharyngeal candidiasis and malnutrition before antiretroviral therapy initiation: a retrospective analysis from a large urban cohort in Johannesburg, South Africa

Long-term effect of Haart on biochemical profiles of HIV/AIDS patients in a tertiary health facility in Benin city, Nigeria

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