2004
DOI: 10.1111/j.1572-0241.2004.30110.x
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Evaluation of Liver Fibrosis: A Concise Review

Abstract: The diagnosis of liver fibrosis has traditionally relied on liver biopsy. However, recent studies have suggested that there can be up to a 33 % error in the diagnosis of cirrhosis. In this article, we review the current status of liver biopsy as a gold standard for the diagnosis of liver fibrosis and discuss the radiological and serum tests that have been proposed as potential adjuncts or alternatives to biopsies. Indirect markers of liver fibrosis which reflect alterations in liver function and or inflammatio… Show more

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Cited by 546 publications
(424 citation statements)
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“…Liver biopsy remains the golden standard for fibrosis evaluation, 25 but variability in the distribution of fibrosis within the liver limits the accuracy of assessment of fibrosis with liver biopsy. 26 Thus, less well-characterized cases and controls may partially account for the inconsistent results in previous genetic association studies.…”
Section: Discussionmentioning
confidence: 99%
“…Liver biopsy remains the golden standard for fibrosis evaluation, 25 but variability in the distribution of fibrosis within the liver limits the accuracy of assessment of fibrosis with liver biopsy. 26 Thus, less well-characterized cases and controls may partially account for the inconsistent results in previous genetic association studies.…”
Section: Discussionmentioning
confidence: 99%
“…To our knowledge, there are no studies using positron emission tomography CT in hepatosplenic schistosomiasis. Non-invasive markers have also been used to predict the presence and degree of LF in hepatic diseases such as hepatitis C, cirrhosis and schistosomiasis (Stone 2000, Guangjin et al 2002, Afdhal & Nunes 2004, Grigorescu 2006. It is worth mentioning that MR reproduces the pathological findings of Symmers' fibrosis more clearly than US does and is naturally less invasive and timeconsuming than histology.…”
Section: Discussionmentioning
confidence: 99%
“…33 Features that would apply to an ideal biomarker have been described and are shown in Table 1. 34,35 Broadly speaking, serum markers of hepatic fibrosis can be considered in 1 of 2 categories: either indirect or direct. Indirect markers reflect alterations in hepatic function but do not directly reflect hepatic ECM metabolism, for example, platelet count, coagulation studies, and hepatic aminotransferases.…”
Section: Serum Markers Of Fibrosismentioning
confidence: 99%