Evaluation of Liver Enzymes for the Prediction of Viremia in Asymptomatic Chronic HBV Infected Pregnant Women (“Elena” Study)

A Correlative Study Between Haematological and Biochemical Parameters in Hepatitis B

“…our results are in agree with Francisca, et al, [29]. Abs Plt was highly significant related to liver infection in the present study compared with non-infected liver, this result is in agreement with the fact stated by others that Plt is a good indicator for liver inflammation and advanced liver fibrosis and strongly related with the HBV status [30][31]. Biomarkers are equally valuable for the estimation and assessment of hepatic disease severity due to HBV infection may alter the levels of certain liver enzymes as a result of hepatocellular damage [32].…”

“…Also very high increment in both ALT and/or GGT obtained in this study can provide a valuable information through the assessment of hepatic inflammation and fibrosis and beside Plt no other biochemical tests have been shown to be a better indicators of liver injury. Another important mediator of host immune defence CRP and Alb showed level increment in sera of HBV individuals compared with controls at (P≤0.05) , our finding is in agreement with other studies [16,30], these findings sound not unusual since liver is the target, organ for the replication of HBV , leading to the demolition of hepatocytes and, consequently increase the releasing of these molecules [18]. The effect of HBV infection on liver's clearance of pancreatic enzymes was followed by evaluation of Amy activity, Table 1, revealed significant increase(p≤0.05) in Amy activity in HBV patients compared with control group, our results are in agreement with Katakura Yet al [36], and Kaur N et al [19].…”

“…High significant increases were observed in ALT, AST, ALP and GGT at (p≤0.05) in HBV compared with control, these results are in agreement with others [22], [33][34]. ALT and GGT showed the highest increments in HBV infection, it has been stated that moderate elevation (3-20 times) of ALT level usually observed in acute hepatitis, neonatal hepatitis, chronic hepatitis, autoimmune hepatitis, drug induced hepatitis, alcoholic hepatitis [30], [33]. other study deduced that the GGT increment that reflects inflammation in, the liver is superior than ALT ,and that GGT may have a significant role in the clinical, evaluation of HBV [34].…”