Evaluation of liver and thyroid toxicity in Sprague-Dawley rats after exposure to polybrominated diphenyl ether BDE-209

Lee, Ena; Kim, Tae Hyung; Choi, Jae Seok; Nabanata, Patra; Kim, Na Young; Ahn, Mee Young; Jung, Kyoung Hwa; Kang, Il Hyun; Kim, Tae Sung; Kwack, Seung Jun; Park, Kui Lea; Kim, Seung Hee; Kang, Tae Seok; Lee, Jaewon; Lee, Byung Mu; Kim, Hyung Sik

doi:10.2131/jts.35.535

Cited by 104 publications

(62 citation statements)

References 28 publications

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“…Table 3 provides a summary of studies in fish conducted to date. Similar to results in fish, in vivo rodent studies and cell-based assays have reported PBDE-induced disruption of thyroid homeostasis, including declines in circulating THs [144][145][146] ; altered expression and activity of TH metabolizing enzymes, 147,148 and competitive binding with plasma transporters. 149 Human epidemiology studies have shown associations between altered plasma concentrations of THs in adults and PBDE levels in serum and dust.…”

Section: Pbde Thyroid Disruption In Fishsupporting

confidence: 61%

PBDE flame retardants

Noyes

Stapleton

2014

Endocrine Disruptors

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Section: Pbde Thyroid Disruption In Fishsupporting

confidence: 61%

PBDE flame retardants

Noyes

Stapleton

2014

Endocrine Disruptors

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“…was found based on a reduction of T4 in one study after exposure at GD6-18 (Kim et al, 2009). Effects on T3 and TSH and no changes in T4 were found in another study in rats exposed to a similar dose at PND10-42 (Lee et al, 2010). Mice seem to be more susceptible to BDE-209 with a NOEL between 10 and 20 mg/kg b.w., however again in one study the NOEL is based on a decrease of T4 (Rice et al, 2007) and in another on decrease of T3 (Tseng et al, 2008).…”

Section: Consideration Of Critical Effects and Possibilities For Derimentioning

confidence: 85%

“…In postnatal exposed rats to BDE-209 a decrease in T3 and in TSH was observed at LOEL 300 mg/kg b.w. (213 μM) (Lee et al, 2010). In rats, BDE-99 caused significant a decrease in serum T4 after single gestational administration at the LOEL of 0.3 mg/kg b.w.…”

Section: Interactions Of Pbdes With the Thyroid Hormone Systemmentioning

confidence: 93%

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Scientific Opinion on Polybrominated Diphenyl Ethers (PBDEs) in Food

2011

EFS2

195

147

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EFSA was asked by the European Commission to deliver a scientific opinion on polybrominated diphenyl ethers (PBDEs) in food. PBDEs are additive flame retardants which are applied in plastics, textiles, electronic castings and circuitry. PBDEs are ubiquitously present in the environment and likewise in biota and in food and feed. Data from the analysis of 19 PBDE congeners in 3,971 food samples were provided to EFSA by 11 European countries. Eight congeners were considered by the Panel on Contaminants in the Food Chain (CONTAM Panel) to be of primary interest: . The highest dietary exposure is to . Toxicity studies were carried out with technical PBDE mixtures or individual congeners. Main targets were the liver, thyroid hormone homeostasis and the reproductive and nervous system. PBDEs cause DNA damage through the induction of reactive oxygen species. The Panel identified effects on neurodevelopment as the critical endpoint, and derived benchmark doses (BMDs) and their corresponding lower 95 % confidence limit for a benchmark response of 10 %, BMDL 10 s, for a number of PBDE congeners: BDE-47, 309 μg/kg b.w.; BDE-99, 12 μg/kg b.w.; BDE-153, 83 μg/kg b.w.; BDE-209, 1,700 μg/kg b.w. Due to the limitations and uncertainties in the current database, the Panel concluded that it was inappropriate to use these BMDLs to establish health based guidance values, and instead used a margin of exposure (MOE) approach for the health risk assessment. Since elimination characteristics of PBDE congeners in animals and humans differ considerably, the Panel used the body burden as starting point for the MOE approach. The CONTAM Panel concluded that for BDE-47, -153 and -209 current dietary exposure in the EU does not raise a health concern. For BDE-99 there is a potential health concern with respect to current dietary exposure. 4 The term "intra-species" has been replaced by "inter-species" in the Summary and in Chapter 9.1. The chemical stability of the PBDE congeners varies with the individual structure. In general PBDE congeners with up to three bromine substituents and those with nine or ten bromine substituents are more sensitive to abiotic transformations. PBDE congeners with four to eight bromine substituents show the highest stability. PBDE congeners are particularly susceptible to photolysis, reductive debromination and radical reactions whereas they are less susceptible to oxidation and hydrolysis. In general, PBDE congeners are persistent and bioaccumulative with the exception of BDE-209 bioaccumulative properties of which seem to be species dependent. BDE-209 undergoes debromination reactions both in the abiotic environment and in biota, leading to formation of PBDE congeners containing seven to nine bromine atoms. © European Food SafetyBased on the composition of the technical PBDE mixtures, occurrence in the environment and in food, the Panel on Contaminants in the Food Chain (CONTAM Panel) considered the following eight PBDE congeners to be of primary interest: which are relevant for dietary PBDE exposur...

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“…[13][14][15][16] Laboratory animals exposed to PCBs and PBDEs develop lesions in thyroid follicular cells, with decreased levels of circulating serum thyroid hormones. 17,18) PCBs and PBDEs exert neurotoxic effects on e-mail: r-shimi@ps.hirokoku-u.ac.jp…”

Section: Thyroid Hormone Disruption By Envi-ronmental Halogenated Chementioning

confidence: 99%

Iodotyrosine Deiodinase, a Novel Target of Environmental Halogenated Chemicals for Disruption of the Thyroid Hormone System in Mammals

Shimizu

2014

Biological & Pharmaceutical Bulletin

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Many synthetic chemicals have been identified as environmental contaminants with activity to disrupt normal function of the thyroid hormone system. Thyroid hormones play important roles in growth, development, differentiation, and basal metabolic homeostasis, as well as in brain development in human fetus and children, and thyroid dysfunction can have very serious consequences, including mental retardation. Environmental chemicals may affect thyroid hormone action in multiple ways, including reduced thyroid hormone synthesis owing to direct toxicity at the thyroid gland, interaction with thyroid hormone receptors and transporters such as transthyretin, and disturbance of thyroid hormone metabolism (e.g., glucuronidation, sulfation and deiodination). In addition, iodotyrosine deiodinase, which is involved in iodide salvage by catalyzing deiodination of iodinated by-products of thyroid hormone production, was recently identified as a possible new target for disruption of thyroid hormone homeostasis by environmental halogenated chemicals. This topic, after briefly summarizing findings on the thyroid hormone-disrupting action of environmental chemicals in mammals, focuses on the effects of environmental halogenated chemicals on iodotyrosine deiodinase activity.

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Evaluation of liver and thyroid toxicity in Sprague-Dawley rats after exposure to polybrominated diphenyl ether BDE-209

Cited by 104 publications

References 28 publications

PBDE flame retardants

PBDE flame retardants

Scientific Opinion on Polybrominated Diphenyl Ethers (PBDEs) in Food

Iodotyrosine Deiodinase, a Novel Target of Environmental Halogenated Chemicals for Disruption of the Thyroid Hormone System in Mammals

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