Evaluation of lipid nanoparticles for topical delivery of protocatechuic acid and ethyl protocatechuate as a new photoprotection strategy

Daré, Regina Gomes; Costa, Ana; Nakamura, C. V.; Truiti, Maria C.T.; Ximenes, Valdecir Farias; Lautenschlager, Sueli O.S.; Sarmento, Bruno

doi:10.1016/j.ijpharm.2020.119336

Cited by 16 publications

(5 citation statements)

References 48 publications

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“… Boakye et al., 2016 Prevention Liposome P0 P2 SLN, nanostructured lipid carrier NLCs showed the ability for controlled release and protective effects against UVB-mediated degradation of P0 and P2. Daré et al., 2020 Prevention Liposome Quercetin Nanostructured lipid carriers Use of NLCs with quercetin in the developed photoprotective formulation significantly increased in vivo SPF without changing the number of UV filters. Exhibited improved effect on skin barrier hydration.…”

Section: Nps In Skin Cancer Preventionmentioning

confidence: 99%

“…NLCs, as described previously, evolved from SLNs in pursuit of improved encapsulation efficiency and stability in addition to decreased cytotoxicity ( Daré et al., 2020 ; Felippim et al., 2020 ). NLCs have been shown to enhance sunscreen photostability and reduce skin irritation ( Damiani and Puglia, 2019 ; Durand et al., 2010 ; Puglia et al., 2012 ; Suh et al., 2019 ).…”

Section: Nps In Skin Cancer Preventionmentioning

confidence: 99%

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Nanoparticles as a Therapeutic Delivery System for Skin Cancer Prevention and Treatment

Chang¹,

Yu²,

Saltzman³

et al. 2023

JID Innovations

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Section: Nps In Skin Cancer Preventionmentioning

confidence: 99%

Section: Nps In Skin Cancer Preventionmentioning

confidence: 99%

Nanoparticles as a Therapeutic Delivery System for Skin Cancer Prevention and Treatment

Chang¹,

Yu²,

Saltzman³

et al. 2023

JID Innovations

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“…Nanotechnology-based drug delivery strategies constitute a potential approach to enhance the poor bioavailability of berberine. Many studies have demonstrated that topical delivery has the characteristics of targeting and performance release controllability, which plays an important role in medical treatment ( Dare et al, 2020 ). Among them, intranasal delivery, as a form of topical delivery, bypasses the blood–brain barrier through the olfactory pathway and trigeminal nerve pathway, directly transporting drugs to the brain ( Dhuria et al, 2010 ).…”

Section: Challenges and Possible Solutionsmentioning

confidence: 99%

Current Evidence and Future Directions of Berberine Intervention in Depression

Zhu

Sun

et al. 2022

Front. Pharmacol.

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A major type of serious mood disorder, depression is currently a widespread and easily overlooked psychological illness. With the low side effects of natural products in the treatment of diseases becoming the pursuit of new antidepressants, natural Chinese medicine products have been paid more and more attention for their unique efficacy in improving depression. In a view from the current study, the positive antidepressant effects of berberine are encouraging. There is a lot of work that needs to be done to accurately elucidate the efficacy and mechanism of berberine in depression. In this review, the relevant literature reports on the treatment of depression and anxiety by berberine are updated, and the potential pharmacological mechanism of berberine in relieving depression has also been discussed.

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“…This structure determines their higher drug-loading ability (compared to solid lipid nanoparticles) and improved drug retention [10]. Various phenolic compounds have been encapsulated in NLCs, thereby obtaining enhanced solubility of the APIs (ellagic acid NLCs), reduced skin irritation and photoprotection (protocatechuic acid NLCs), and improved skin penetration and bioavailability (resveratrol NLCs) [11][12][13]. Nevertheless, the topical effects of NLCs may be further improved when sufficient skin contact time is provided, e.g., through their inclusion in a semisolid vehicle.…”

Section: Introductionmentioning

confidence: 99%

Bigel Formulations of Nanoencapsulated St. John’s Wort Extract—An Approach for Enhanced Wound Healing

Sotirova

Gugleva

Stoeva

et al. 2023

Gels

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This study aimed to develop a semisolid vehicle for topical delivery of nanoencapsulated St. John’s wort (SJW) extract, rich in hyperforin (HP), and explore its wound-healing potential. Four nanostructured lipid carriers (NLCs) were obtained: blank and HP-rich SJW extract-loaded (HP-NLC). They comprised glyceryl behenate (GB) as a solid lipid, almond oil (AO), or borage oil (BO) representing the liquid lipid, along with polyoxyethylene (20) sorbitan monooleate (PSMO) and sorbitan monooleate (SMO) as surfactants. The dispersions demonstrated anisometric nanoscale particles with acceptable size distribution and disrupted crystalline structure, providing entrapment capacity higher than 70%. The carrier exhibiting preferable characteristics (HP-NLC2) was gelled with Poloxamer 407 (PM407) to serve as the hydrophilic phase of a bigel, to which the combination of BO and sorbitan monostearate (SMS) organogel was added. The eight prepared bigels with different proportions (blank and nanodispersion-loaded) were characterized rheologically and texturally to investigate the impact of the hydrogel-to-oleogel ratio. The therapeutic potential of the superior formulation (HP-NLC-BG2) was evaluated in vivo on Wistar male rats through the tensile strength test on a primary-closed incised wound. Compared with a commercial herbal semisolid and a control group, the highest tear resistance (7.764 ± 0.13 N) was achieved by HP-NLC-BG2, proving its outstanding wound-healing effect.

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Evaluation of lipid nanoparticles for topical delivery of protocatechuic acid and ethyl protocatechuate as a new photoprotection strategy

Cited by 16 publications

References 48 publications

Nanoparticles as a Therapeutic Delivery System for Skin Cancer Prevention and Treatment

Nanoparticles as a Therapeutic Delivery System for Skin Cancer Prevention and Treatment

Current Evidence and Future Directions of Berberine Intervention in Depression

Bigel Formulations of Nanoencapsulated St. John’s Wort Extract—An Approach for Enhanced Wound Healing

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