Evaluation of Lipid Levels in Patients Infected With Helicobacter Pylori

Küçükazman, Metin; Yavuz, Burcu Balam; Sacikara, Muhammed; Asiltürk, Zeliha; Ata, Naim; Ertuğrul, Derun Taner; Yalçın, Ahmet Arif; Kızılca, Güler; Yenigun, Ezgi Coskun; Ülger, Zülal; Nazlıgül, Yaşar

doi:10.1016/s1567-5688(08)70331-3

Cited by 1 publication

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“…Besides, it has been reported that SAA inhibits lecithin-cholesterol acyltransferase activity, and both mechanisms can reduce the concentrations of HDL-C (1). Our results are in agreement with the studies which have observed no significant difference in HDL-C and apo A-I levels between HP seropositive and seronegative subjects (2,5,10,18).…”

Section: Discussionsupporting

confidence: 93%

“…In a study of Kanbay et al (20), normalization in lipid parameters after a successful eradication of HP infection was observed. Majka et al (4) and Kucukazman et al (18) found that plasma levels of TC and LDL-C were significantly higher in HP seropositive subjects, and after 6 months of successful anti-HP therapy those levels were significantly lowered (4). Hoffmeister et al (19) reported an atherogenic modified lipid profile associated with HP infection and after multivariable adjustment, association with increased apo B levels persisted and remained significant (p=0.02).…”

Section: Discussionmentioning

confidence: 99%

“…Although most authors reported about an association between HP infection and a proatherogenic lipid profile (6,(16)(17)(18)(19) which was normalized after successful eradication of HP (4,20), few studies did not confirm these results (1,2,5,10,21). Therefore, the influence of chronic HP infection on lipid parameter changes and their implication in atherogenic mechanisms of this infection are still unclear.…”

Section: Introductionmentioning

confidence: 99%

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The Influence of Chronic Helicobacter Pylori Infection on some Serum Lipid Profile Parameters, Apolipoproteins A-I and B and Lp(a) Lipoprotein

Kojić-Damjanov¹,

Đerić²,

Eremić³

et al. 2009

Journal of Medical Biochemistry

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Kratak sadr`aj: Podaci o proaterogenim promenama lipidskog statusa u sklopu hroni~ne Helicobacter pylori (HP) infekcije su kontradiktorni. Cilj istra`ivanja bio je da se ispitaju razlike u nekim lipidskim parametrima izme|u 55 osoba oba pola s hroni~nom HP infekcijom (IgG >50 U/mL i IgA <20 U/mL) i 55 HP seronegativnih osoba (IgG i IgA <20 U/mL) oba pola. Serumske koncentracije ukupnog holesterola (TC) (p<0,001), triglicerida (TG) (p<0,05), LDL-holesterola (LDL-C) (p<0,02), non-HDL-holesterola (non-HDL-C), apolipoproteina (apo) B (p<0,001), Lp(a) i HDL-holesterola (HDL-C) bile su vi{e kod HP seropozitivnih u odnosu na seronegativne osobe, dok gotovo da nije bilo razlika u nivoima apo A-I. Kod HP seropozitivnih osoba, u~estalost patolo{kih TC (p<0,001), TG (p<0,05), LDL-C (p<0,01), non-HDL-C (p<0,01), apo B (p<0,02) i Lp(a) vrednosti bila je vi{a u odnosu na seronegativne. Ustanovljena je negativna korelacija serum skih titara HP IgG antitela s TC, LDL-C (p<0,05), non-HDL-C, apo B i Lp(a), a pozitivna s TG, HDL-C i apo A-I nivoima. Rezultati su sli~ni za oba pola. Na{i rezultati idu u prilog hipotezi da bi hroni~na HP infekcija mogla da modifikuje lipidske parametre na proate rogeni na~in.Klju~ne re~i: ateroskleroza, Helicobacter pylori, lipidi, aterogeni rizik Summary: Data on proatherogenic lipid profile alterations due to chronic Helicobacter pylori (HP) infection are contradictory. Aim of this study was to examine the differences in some lipid parameters between 55 subjects of both gender with a chronic HP infection (IgG>50 U/mL and IgA <20 U/mL) and 55 gender matched HP seronegative subjects (IgG and IgA <20 U/mL). Total cholesterol (TC) (p<0.001), triglycerides (TG) (p<0.05), LDL-cholesterol (LDL-C) (p<0.02), non-HDL-cholesterol (non-HDL-C), apolipoprotein (apo) B (p<0.001), Lp(a) and HDL-cholesterol (HDL-C) serum levels were higher in HP seropositive than in seronegative subjects, while there were almost no differences in apo A-I. In HP seropositive subjects, the frequency of pathological TC (p<0.001), TG (p<0.05), LDL-C (p<0.01), non-HDL-C (p<0.01), apo B (p<0.02) and Lp(a) serum levels was higher compared to seronegative. Serum HP IgG titers correlated negatively with TC, LDL-C (p<0.05), non-HDL-C, apo B and Lp(a) levels, and positively with TG, HDL-C and apo A-I levels. Results are similar for both genders. Our results confirm the hypothesis that a chronic HP infection could modify the lipid profile in a proatherogenic way.

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Section: Discussionsupporting

confidence: 93%