1999
DOI: 10.1038/sj.mp.4000454
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Evaluation of linkage of bipolar affective disorder to chromosome 18 in a sample of 57 German families

Abstract: Previously reported linkage of bipolar affective disorder to DNA markers on chromosome 18 was reexamined in a large sample of German bipolar families. Twenty-three short tandem repeat markers were investigated in 57 families containing 103 individuals with bipolar I disorder (BPI), 26 with bipolar II disorder (BPII), nine with schizoaffective disorder of the bipolar type (SA/BP), and 38 individuals with recurrent unipolar depression (UPR). Evidence for linkage was tested with parametric and non-parametric meth… Show more

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Cited by 119 publications
(81 citation statements)
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References 34 publications
(48 reference statements)
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“…This region was subsequently confirmed in several BPAD linkage studies, 2,3 and provided the maximum LOD score in a study of chromosome 18 in 59 German and Israeli SZ pedigrees. 4 It is worth noting that the study by Schwab et al included 24 cases of affective disorders, including two with BPAD.…”
mentioning
confidence: 64%
“…This region was subsequently confirmed in several BPAD linkage studies, 2,3 and provided the maximum LOD score in a study of chromosome 18 in 59 German and Israeli SZ pedigrees. 4 It is worth noting that the study by Schwab et al included 24 cases of affective disorders, including two with BPAD.…”
mentioning
confidence: 64%
“…Those findings are, however, not universal (Badner and Gershon, 2002;Van Broeckhoven and Verheyen, 1999), and their interpretation is further complicated by the putative presence of a parent-of-origin effect in this region (Petronis, 2000). Stronger evidence of linkage has been reported in this region for bipolar families with paternal transmission of the phenotype (Gershon et al, 1996;Nothen et al, 1999;Stine et al, 1995), and with maternal pedigrees for schizophrenia (Schwab et al, 1998). The investigation of GNAL as a candidate gene in this region for both bipolar disorder (Tsiouris et al, 1996;Turecki et al, 1996;Zill et al, 2003) and major depression (Zill et al, 2002) yielded negative results.…”
Section: Discussionmentioning
confidence: 99%
“…The GNAL gene is located on the short arm of chromosome 18 in a region that has been linked to bipolar disorder and schizophrenia (Berrettini, 2000;Schwab et al, 2000;Segurado et al, 2003), with some evidence of parent-of-origin effects (Gershon et al, 1996;Nothen et al, 1999;Stine et al, 1995). However, replication studies have led to conflicting results (Van Broeckhoven and Verheyen, 1998;Zill et al, 2003).…”
Section: Introductionmentioning
confidence: 99%
“…5,12 Parent-of-origin effects imply an epigenetic mechanism of inheritance and may be a compelling hypothesis to explain complex genetic disorders such as bipolar disorder. [44][45][46] The paternal allele sharing in the Fallin et al 9 linkage study is described by microsatellite markers D18S59 and D18S63; the two loci (four SNPs) with putative parent-of-origin effects in this study map between these two markers and is therefore consistent with previous results.…”
Section: Discussionmentioning
confidence: 99%
“…11 There is also evidence for a parent-of-origin effect on linkage evidence at the 18p11 locus. 5,9,12 It is important to note that many studies have failed to find linkage evidence to chromosome 18p11. The lack of agreement in findings from genetic studies may be attributable to etiologic heterogeneity of bipolar disorder; it may also be due to lack of consistency in ascertainment or diagnostic methods, or to low statistical power, as many linkage studies have a small number of pedigrees for analysis.…”
Section: Introductionmentioning
confidence: 99%