Evaluation of Levofloxacin Release Characteristics from a Human Foldable Capsular Vitreous Body<i>In Vitro</i>

Jiang, Zhaoxin; Wang, Peijuan; Pan, Biyan; Xie, Zenghong; De-tang, LI; Wang, Ting; Liu, Yaqin; Yuan, Zhihang; Gao, Qianying

doi:10.1089/jop.2011.0109

Cited by 11 publications

(12 citation statements)

References 25 publications

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“…PVP, PAA) tamponade. Moreover, many nanometer-wide apertures exist in the FCVB, and drugs can be released from the FCVB3637383940, so a drug may be added to the hydrogels, providing clinicians with a slow-release drug device. Therefore, this novel approach may develop into a new ideal vitreous substitute and open new options for the prevention and treatment of vitreous retinal diseases.…”

Section: Discussionmentioning

confidence: 99%

A Novel Vitreous Substitute of Using a Foldable Capsular Vitreous Body Injected with Polyvinylalcohol Hydrogel

Feng

Chen

Liu

et al. 2013

Sci Rep

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Hydrogels may be the ideal vitreous substitutes due to their wonderful physical features and biocompatibility. However, their drawbacks, short residence time, and biodegradation in vivo, have led to the fact that none of them have been approved for clinical use. In this study, we developed a novel approach of using a foldable capsular vitreous body (FCVB) injected with polyvinylalcohol (PVA) hydrogel as a vitreous substitute for long-term tamponade. The 3% PVA hydrogel that was cross-linked by gamma irradiation showed good rheological and physical properties and had no toxicity in vitro. After 180 days retention, the 3% PVA hydrogel inside FCVB remained transparent and showed good viscoelasticity without biodegradation and showed good biocompatibility and retina support. This new approach may develop into a valuable tool to improve the stability performance of PVA hydrogel as a vitreous substitute and to extend the application function of FCVB for long-term implantation in vitreous cavity.

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Section: Discussionmentioning

confidence: 99%

A Novel Vitreous Substitute of Using a Foldable Capsular Vitreous Body Injected with Polyvinylalcohol Hydrogel

Feng

Chen

Liu

et al. 2013

Sci Rep

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“…42 Therefore, FCVB results also may have implications in the treatment of important retinal diseases that need drug and vitreous substitutes, such as age-related macular degeneration, proliferative vitreoretinopathy, and proliferative diabetic retinopathy. This work, along with our other reports regarding the FCVB, [21][22][23][24][25][26][27][28][29][30]42 give an example of how to make the product from bench to bedside, including idea, craft, animal model, producing standard, technical reports from government, clinical trails (exploratory, multiple centers), and marketing. Based on this study, we will apply for a new clinical trial to test the combined function of FCVB.…”

Section: Discussionmentioning

confidence: 97%

“…In our previous study, the in vitro release of levofloxacin more than doubles from a human FCVB with concentrations of 500 lg/ml. 25 The reason probably is that the sizes and apertures in human FCVB are 3 times those in rabbits. The in vivo release rate was relatively faster than the in vitro release rate.…”

Section: Discussionmentioning

confidence: 99%

“…19,20 In our previous studies, we proposed a new strategy to fabricate a vitreous substitute with a novel foldable capsular vitreous body (FCVB). [21][22][23][24][25][26] The FCVB, made with modified liquid silicone rubber, consists of a thin, vitreous-like capsule finely mimicked by computer, and a tube-valve system. After the FCVB capsule is folded and implanted in the vitreous cavity, a balanced salt solution (BSS) and/or therapeutic drugs then can be injected into the capsule, and the capsule inflated to support the retina.…”

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confidence: 99%

“…22,23 Interestingly, numerous 300 nm tiny apertures were observed in the FCVB capsule, and we uncovered its potential use as a DDS for the ophthalmic drug dexamethasone sodium phosphate in the rabbit eye. 24 Moreover, we determined that the human FCVB could release levofloxacin in vitro, 25 as well as the rabbit FCVB could release levofloxacin in vitro and vivo. 26 Here, we tested further whether the FCVB could serve as a vitreous substitute and DDS in the rabbit endophthalmitis model.…”

mentioning

confidence: 99%

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A Preliminary Study to Treat Severe Endophthalmitis via a Foldable Capsular Vitreous Body with Sustained Levofloxacin Release in Rabbits

Wang¹,

Huang²,

Gao³

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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Macro- and Microscale Properties of the Vitreous Humor to Inform Substitute Design and Intravitreal Biotransport

Tram

Maxwell

Swindle-Reilly

2020

Current Eye Research

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Research on the vitreous humor and development of hydrogel vitreous substitutes have gained a rapid increase in interest within the past two decades. However, the properties of the vitreous humor and vitreous substitutes have yet to be consolidated. In this paper, the mechanical properties of the vitreous humor and hydrogel vitreous substitutes were systematically reviewed. The number of publications on the vitreous humor and vitreous substitutes over the years, as well as their respective testing conditions and testing techniques were analyzed. The mechanical properties of the human vitreous were found to be most similar to the vitreous of pigs and rabbits. The storage and loss moduli of the hydrogel vitreous substitutes developed were found to be orders of magnitude higher in comparison to the native human vitreous. However, the reported modulus for human vitreous, which was most commonly tested in vitro, has been hypothesized to be different in vivo. Future studies should focus on testing the mechanical properties of the vitreous in situ or in vivo. In addition to its mechanical properties, the vitreous humor has other biotransport mechanisms and biochemical functions that establish a redox balance and maintain an oxygen gradient inside the vitreous chamber to protect intraocular tissues from oxidative damage. Biomimetic hydrogel vitreous substitutes have the potential to provide ophthalmologists with additional avenues for treating and controlling vitreoretinal diseases while preventing complications after vitrectomy. Due to the proximity and interconnectedness of the vitreous humor to other ocular tissues, particularly the lens and the retina, more interest has been placed on understanding the properties of the vitreous humor in recent years. A better understanding of the properties of the vitreous humor will aid in improving the design of biomimetic vitreous substitutes and enhancing intravitreal biotransport.

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Evaluation of Levofloxacin Release Characteristics from a Human Foldable Capsular Vitreous BodyIn Vitro

Cited by 11 publications

References 25 publications

A Novel Vitreous Substitute of Using a Foldable Capsular Vitreous Body Injected with Polyvinylalcohol Hydrogel

A Novel Vitreous Substitute of Using a Foldable Capsular Vitreous Body Injected with Polyvinylalcohol Hydrogel

A Preliminary Study to Treat Severe Endophthalmitis via a Foldable Capsular Vitreous Body with Sustained Levofloxacin Release in Rabbits

Macro- and Microscale Properties of the Vitreous Humor to Inform Substitute Design and Intravitreal Biotransport

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